Modulation of Cutaneous Fatty Acid-binding Protein mRNA Expression in Rat Adipose Tissues by Hereditary Obesity and Dietary Fats

Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats

“…Here, in livers of high-cholesterol diet rats, it maintained high expression levels for 12 weeks; and in adipose tissue, first down-regulation (at 4 and 8 weeks), then up-regulation (at 12 weeks) was displayed. This is in accordance with not only our previous study, but also another study with obese rats (49). In conclusion, compared with HC groups, hesperidin supplementation (HHC group) attenuated the marked changes in mRNA expression, although the reason is still unknown.…”

“…H-FABP regulates metabolic homeostasis by modulating intracellular lipid transport in cardiac muscles (45). FABP mRNA expression has been reported to increase in abdominal white adipose tissue in rats fed a high-fat diet for 30 days (12). However, in cardiac muscle, H-FABP mRNA expression was down-regulated in rats fed a high-fat diet for 65 days (46).…”

“…During the progression of hypercholesterolemia, the expression of genes and proteins related to lipid metabolism, including retinoid-binding protein (RBP) (10), and fatty acid-binding proteins (FABPs) changes (11,12). Cutaneous fatty acid-binding protein (C-FABP) and heart fatty acid-binding protein (H-FABP) belong to FABPs which are members of the superfamily of lipidbinding proteins (13).…”

Upregulation of mRNA of retinoid binding protein and fatty acid binding protein by cholesterol enriched-diet and effect of ginger on lipid metabolism

“…Hyperlipidemia is affected by the intake of high calorie and high fat diets. Hyperlipidemia is associated with changes of expression of genes and proteins related to lipid metabolism, including retinoid binding protein (RBP) (Soprano et al 1986;Tsutsumi et al 1992;Kushiro et al 2004), and fatty acid binding proteins (FABPs) (Margareto et al 2001;Kushiro et al 2007). RBP mRNA is expressed in liver, kidney (Soprano et al 1986), and adipose tissue (Tsutsumi et al 1992), and RBP mRNA expression in white adipose tissue is upregulated in obese rats fed a high fat diet (Kushiro et al 2004).…”

“…Cutaneous FABP (C-FABP), also known as psoriasisassociated FABP, keratinocyte FABP or epidermal FABP, is a member of the intracellular lipid-binding protein multigene family (Zimmerman and Veerkamp 2002). Obese rats induced by a high fat diet show increases in adipocyte FABP (aP2) mRNA expression and C-FABP mRNA in visceral white adipose tissues (Margareto et al 2001;Kushiro et al 2007). H-FABP has not been studied in adipose tissues yet.…”