Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study

Kunisato, Yoshihiko; Okamoto, Yasumasa; Okada, Go; Aoyama, Shiori; Demoto, Yoshihiko; Munakata, Ayumi; Nomura, Michio; Onoda, Keiichi; Yamawaki, Shigeto

doi:10.1016/j.neures.2010.11.005

Cited by 62 publications

(49 citation statements)

References 34 publications

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“…Kunisato et al performed a resting-state fMRI study with 21 healthy men in which they showed that changes in some subscores of the POMS correlated with changes in orbitofrontal cortex (OFC) activity of the brain under ATD. Less activity of the OFC was associated with an increase of depressive mood during the depletion situation [38]. To the best of our knowledge, there are no imaging studies which investigate the influence of orally administered 5-HTP supplementation on the brain.…”

Section: Discussionmentioning

confidence: 99%

The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment

Sauer

Mack

Kohler

et al. 2014

Gastroenterology Research and Practice

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Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order. Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted. Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE. Results. GE was delayed with butter and was normal with olive (P < 0.05) but not affected by 5-HTP. 5-HTP supplementation did not affect serotonin levels. Food intake increased plasma CCK (F = 6.136; P < 0.05) irrespective of the FA. Ghrelin levels significantly decreased with oil/5-HTP (F = 9.166; P < 0.001). The diurnal cortisol profile was unaffected by FA or 5-HTP, as were ratings of mood, hunger, and stool urgency. Conclusion. Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones. Supplementation of 5-HTP had no effect on plasma serotonin and central functions. Further studies are needed to explain the complex interplay.

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Section: Discussionmentioning

confidence: 99%

The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment

Sauer

Mack

Kohler

et al. 2014

Gastroenterology Research and Practice

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“…Correlates such as poor anger management, poor impulse control, increased substance abuse, and greater long-term psychosocial dysfunction raise the question of whether MDEs with irritability/anger arise from a distinct biological substrate. Recent evidence indicates a possible relationship between anger attacks during MDEs and serotonergic dysfunction, [31][32][33][34] including its effects on specific brain regions, 35 as well as subcortical vascular lesions, 36 on particular patterns of cerebral blood flow, 37 and on factors related to vascular morbidity. 38,39 Katz et al 31 have compiled an impressive body…”

Section: Implications For Clinical Research and Practicementioning

confidence: 99%

Overt Irritability/Anger in Unipolar Major Depressive Episodes

Judd

Schettler

Coryell³

et al. 2013

JAMA Psychiatry

173

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IMPORTANCE Although symptoms of irritability or anger are not central to the diagnosis of unipolar major depressive episodes (MDEs), these symptoms have been found, in cross-sectional studies, to be highly prevalent and associated with increased comorbidity and depressive illness burden.OBJECTIVE To determine the prevalence of overtly expressed irritability/anger and its effect on intake presentation and the long-term course of illness. DESIGN A prospective, naturalistic investigation of patients with unipolar MDEs, studied systematically at intake and during up to 31 years of follow-up. SETTING Five US academic medical centers.

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“…Therefore, non-specific signal components could be effectively suppressed by this technology, and the sensitivity and specificity in examining regional spontaneous brain activity could be significantly improved [19], [20]. So far, this method has been successfully used to investigate the brain function in healthy subjects [21] and clinical populations [22]–[28].…”

Section: Introductionmentioning

confidence: 99%

Dissociation of Regional Activity in Default Mode Network in Medication-Naive, First-Episode Somatization Disorder

Yao

Jiang

et al. 2014

PLoS ONE

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BackgroundPatients with somatization disorder (SD) have altered neural activity in the brain regions of the default mode network (DMN). However, the regional alteration of the DMN in SD remains unknown. The present study was designed to investigate the regional alterations of the DMN in patients with SD at rest.MethodsTwenty-five first-episode, medication-naive patients with SD and 28 age-, sex-, education- matched healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI) scan. The fractional amplitude of low-frequency fluctuations (fALFF) was applied to analyze the data.ResultsPatients with SD showed a dissociation pattern of resting-state fALFF in the DMN, with increased fALFF in the bilateral superior medial prefrontal cortex (MPFC, BA8, 9) and decreased fALFF in the left precuneus (PCu, BA7). Furthermore, significantly positive correlation was observed between the z values of the voxels within the bilateral superior MPFC and somatization subscale scores of the Symptom Check List (SCL-90) in patients with SD.ConclusionsOur findings indicate that there is a dissociation pattern of the anterior and posterior DMN in first-episode, treatment-naive patients with SD. The results provide new insight for the importance of the DMN in the pathophysiology of SD.

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Modulation of default-mode network activity by acute tryptophan depletion is associated with mood change: A resting state functional magnetic resonance imaging study

Cited by 62 publications

References 34 publications

The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment

The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment

Overt Irritability/Anger in Unipolar Major Depressive Episodes

Dissociation of Regional Activity in Default Mode Network in Medication-Naive, First-Episode Somatization Disorder

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