Modulation of diabetes-mellitus-induced male reproductive dysfunctions in experimental animal models with medicinal plants

Abstract

Today diabetes mellitus has emerged as a major healthcare problem throughout the world. It has recently broken the age barrier and has been diagnosed in younger people also. Sustained hyperglycemia is associated with many complications including male reproductive dysfunctions and infertility. Numerous medicinal plants have been used for the management of the diabetes mellitus in various traditional system of medicine and in folklore worldwide as they are a rich source of bioactive phytoconstituents, which lower blood glucose level and/or also act as antioxidants resulting in the amelioration of oxidative-stress-induced diabetic complications. The present review describes the ameliorative effects of medicinal plants or their products, especially on male reproductive dysfunctions, in experimental diabetic animal models.

Protective effects of <i>Lycium barbarum</i> polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic male mice

“…Functional outcome of the morphological improvement by LBP in the male mice subjected to STZ was further studied. It is well known that long-term hyperglycemia can cause loss of libido and low quality sperm [42][43][44]. In animal studies, it has also been demonstrated that the ML and IL extended with decreased MF, IF and increased PEI and EL in diabetic animals.…”

Effect of Kaempferia parviflora on sexual performance in streptozotocin-induced diabetic male rats

“…Diabetes mellitus (DM) is a chronic metabolic disease. It is rapidly emerging as a major public health problem that demands special attention in term of its management (Jain & Jangir, ; Jangir and Jain, ). The number of diabetic patients is rapidly increasing each year especially in developing countries due to the lifestyle and dietary habits.…”

Melatonin Ratlarda Alloxan İle İndüklenen Diyabet Sonrası Oluşan Testiküler Hasarı ve Oksidatif Etkileri Hafifletir

“…The DM is characterized by a sudden and distinct loss in body weight, a symptom as also observed herein. The decreases in body and testis weights of DM rats showed the damage or destruction of structural proteins related to diabetes [3] . When diabetic rats were treated with the MLT, a weight loss in the body was reversed.…”

“…Further, it may lead to a decrease in libido and fertility, thus people's quality of life and life expectancy could become inevitablely reduced [3] . AKMAN, ŞENGÜL, ÖZKANLAR, CAN KOÇ, KARADENİZ, ŞİMŞEK The well-known effect of alloxan, used herein as diabetic agent, on the β-cells in pancreas is to cause the development of insufficient synthesis of insulin and, thus, increasing the blood glucose levels.…”

“…It is associated with a high risk of atherosclerosis, thus having a destructive effect on the organs of renal, nervous, and ocular systems. Moreover, reproductive impairment is a common complication of DM in both genders [2,3] . Streptozotocin (STZ) is used in the treatment of neoplastic β-cell and in the formation of DM type-1 animal model.…”