Modulation of Drug-Metabolizing Systems by Bacterial Endotoxin in Carp Liver and Immune Organs

Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio)

“…Since LPS was injected 60 h after 3-MC administration, this compound might not have prevented induction but acted directly on induced levels to reduce them. Previous studies in our laboratory have shown that LPS regulates biotransformation activities in liver and immune organs of carp [22]. In mammals, inflammatory cytokines such as TNFa, IL1a or IL6 have been proposed to be mediators of LPS-induced-regulation of P450 activities [12,15,18].…”

“…The action of LPS and PWM is mediated by the production of several cytokines such as TNFa and IL6 [20,21]. In carp, it has been shown that LPS modulates biotransformation activities [22]. The mechanism by which LPS regulates biotransformation activities and the implication of inflammatory cytokines in this mechanism has not been elucidated to date in fish.…”

Antibacterial Agents in Mediterranean Finfish Farming: A Synopsis of Drug Pharmacokinetics in Important Euryhaline Fish Species and Possible Environmental Implications

“…Coyne et al (2004a) reported a dramatic difference in the oxolinic acid (OA) concentrations between healthy and moribund rainbow trout (Oncorhynchus mykiss) (<0.005 versus >0.015 lg mL )1 ). The metabolic capacity of common carp (Cyprinus carpio) was also found to be altered during bacterial infection since bacterial endotoxin caused basal hepatic cytochrome P450 activity levels to be significantly lower in infected liver (Marionnet et al, 1998). The efficacy of a treatment is commonly evaluated by the integration of MIC values with maximum drug concentrations in plasma.…”

Cyanotoxins: Bioaccumulation and Effects on Aquatic Animals

“…They concluded that exposure of fish to toxic Microcystis promoted osmoregulatory imbalance resulting from stimulation of the drinking response, increased volume of fluid in the gut and inability to remove water excess. Bacterial LPS is known to affect numerous systems, including the liver detoxication system [186,187] and it is likely that cyanobacterial LPS exhibits similar effects to their bacterial counterparts [188], including the inhibition of glutathione S -transferases [189]. …”