Modulation of drug resistance in Staphylococcus aureus by 132-hydroxy-(132-R/S)-pheophytin isolated from Sargassum polyceratium

Menezes-Silva, Suellen Maria P; Lira, Narlize Silva; Nascimento, Yuri Mangueira do; Meireles, Roseana Araújo Ramos; Dias, Celidarque da Silva; Tavares, Josean Fechine; Silva, Marcelo Sobral da; Miranda, George Emmanuel Cavalcanti de; Barbosa-Filho, José Maria; Siqueira-Júnior, José P.

doi:10.1016/j.micpath.2020.104034

Cited by 3 publications

(4 citation statements)

References 27 publications

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“…Pheophytin (Sp-1) (19) (Figure 5) isolated from Sargassum polyceratium was evaluated regarding its antibacterial and antibiotic-modifying activity in strains of S. aureus with efflux pumps. Compound 19 did not present significant antibacterial activity; however, in combination with erythromycin and norfloxacin, it changed the antibiotic activity, decreasing bacterial resistance by two to four times [50].…”

Section: Ochrophytamentioning

confidence: 90%

Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects

et al. 2023

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Brazil has a megadiversity that includes marine species that are distributed along 800 km of shoreline. This biodiversity status holds promising biotechnological potential. Marine organisms are important sources of novel chemical species, with applications in the pharmaceutical, cosmetic, chemical, and nutraceutical fields. However, ecological pressures derived from anthropogenic actions, including the bioaccumulation of potentially toxic elements and microplastics, impact promising species. This review describes the current status of the biotechnological and environmental aspects of seaweeds and corals from the Brazilian coast, including publications from the last 5 years (from January 2018 to December 2022). The search was conducted in the main public databases (PubChem, PubMed, Science Direct, and Google Scholar) and in the Espacenet database (European Patent Office—EPO) and the Brazilian National Property Institute (INPI). Bioprospecting studies were reported for seventy-one seaweed species and fifteen corals, but few targeted the isolation of compounds. The antioxidant potential was the most investigated biological activity. Despite being potential sources of macro- and microelements, there is a literature gap regarding the presence of potentially toxic elements and other emergent contaminants, such as microplastics, in seaweeds and corals from the Brazilian coast.

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Section: Ochrophytamentioning

confidence: 90%

Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects

et al. 2023

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“…Various plant-based compounds and essential oils have been shown to increase the susceptibility of the NorA-overexpressing strain of S. aureus to fluoroquinolone antibiotics [89,[138][139][140][141][142][143]. Chalcones are unsaturated ketones that occur naturally in some yellowpigmented flowers, the EPI potential of which has been well documented, particularly against the NorA efflux pump [129,144].…”

Section: Inhibition Of Mfs Efflux Pumps Of S Aureus 71 Nora Norb and ...mentioning

confidence: 99%

“…A compound called phyllanthin extracted from Phyllanthus amarus resulted in a five-fold decrease in the norfloxacin MIC while creating an H bond with the residues Gln-51 and Asp-510 of the NorA efflux pump [154]. Coumarin derivatives docked with the NorA efflux pump interacted with the Lys-316, Asn-307, and Lys-273 residues, resulting in an eight-fold MIC reduction against norfloxacin [141]. Docking studies have shown that the amide group of synthetic riparin could form H bonds with the amide oxygen of Asn-340 and amide nitrogen of Gln-51, stabilizing the docking [144].…”

Section: Inhibition Of Mfs Efflux Pumps Of S Aureus 71 Nora Norb and ...mentioning

confidence: 99%

The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus

et al. 2023

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The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public health concern for centuries. Throughout its evolutionary course, S. aureus has developed strains with resistance to antimicrobial agents. The bacterial pathogen has acquired multidrug resistance, causing, in many cases, untreatable infectious diseases and raising serious public safety and healthcare concerns. Amongst the various mechanisms for antimicrobial resistance, integral membrane proteins that serve as secondary active transporters from the major facilitator superfamily constitute a chief system of multidrug resistance. These MFS transporters actively export structurally different antimicrobial agents from the cells of S. aureus. This review article discusses the S. aureus-specific MFS multidrug efflux pump systems from a molecular mechanistic perspective, paying particular attention to structure–function relationships, modulation of antimicrobial resistance mediated by MFS drug efflux pumps, and direction for future investigation.

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“…Resistance-modifying agents/modulators are compounds that potentiate the activity of an antibiotic against resistant strains, and some of these agents may act as efflux pump inhibitors (EPIs), as in the case of several naturally occurring compounds from plants [12][13][14][15][16]. Various phytocompounds have been studied for its ability to inhibit S. aureus efflux pumps, including terpenes such as eugenol [17], carvacrol, thymol [18], estragole [19], α-pinene, and limonene [20].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Drug Resistance by Furanochromones in NorA Overexpressing Staphylococcus Aureus

Rodrigues

Borges

Nogueira

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Khellin and visnagin are natural furanochromones that photoreact with DNA. Khellin has been used in the treatment of vitiligo and psoriasis, as well as in the treatment of angina pectoris and asthma due to its potent action as a coronary vasodilator and antispasmodic agent. The present study aimed to investigate whether the compounds khellin and visnagin act as inhibitors of NorA protein, an efflux pump overproduced by the strain of Staphylococcus aureus SA-1199B that confers resistance to the fluoroquinolones, such as norfloxacin and ciprofloxacin. These substances alone did not show antibacterial activity against the strain tested. On the other hand, when these compounds were added to the culture medium at subinhibitory concentration, they were able to reduce the minimum inhibitory concentration (MIC) of norfloxacin, ethidium bromide, as well as berberine, suggesting that these compounds are modulating agents of norfloxacin resistance, possibly due to NorA inhibition. Molecular docking analysis showed that both khellin and visnagin form hydrogen bonds with Arg310, an important residue in the interaction between NorA and its substrates, supporting the hypothesis that these compounds are NorA inhibitors. These results suggest a possible application of khellin and visnagin as adjuvants to norfloxacin in the treatment of infections caused by strains of S. aureus that overproduce NorA.

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Modulation of drug resistance in Staphylococcus aureus by 132-hydroxy-(132-R/S)-pheophytin isolated from Sargassum polyceratium

Cited by 3 publications

References 27 publications

Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects

Seaweeds and Corals from the Brazilian Coast: Review on Biotechnological Potential and Environmental Aspects

The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus

Modulation of Drug Resistance by Furanochromones in NorA Overexpressing Staphylococcus Aureus

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