Modulation of EEG spectral edge frequency during patterned pneumatic oral stimulation in preterm infants

Song, Dongli; Jegatheesan, Priya; Weiss, Sunshine; Govindaswami, Balaji; Wang, Jingyan; Lee, Jae‐Hoon; Oder, Austin; Barlow, Steven M.

doi:10.1038/pr.2013.179

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…Recent evidence has shown the same PULSED orocutaneous stimulation, as used in the present study, is highly effective in modulating brain activity as reflected in amplitude-integrated EEG and range-EEG measurements sampled in preterm infants at 32 weeks PMA. 38 , 39 One unexpected finding in the present study was the increased LOS for RDS infants who received the PULSED orocutaneous treatment and manifest significant NNS performance increases. One likely reason is the relatively late introduction of the PULSED orosensory treatment (~ 34.5 weeks PMA).…”

Section: Discussionmentioning

confidence: 51%

Frequency-modulated orocutaneous stimulation promotes non-nutritive suck development in preterm infants with respiratory distress syndrome or chronic lung disease

et al. 2013

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BackgroundFor the premature infant, extrauterine life is a pathological condition which greatly amplifies the challenges to the brain in establishing functional oromotor behaviors. The extent to which suck can be entrained using a synthetically patterned orocutaneous input to promote its development in preterm infants who manifest chronic lung disease is unknown.ObjectiveTo evaluate the effects of a frequency-modulated orocutaneous pulse train delivered through a pneumatically-charged pacifier capable of enhancing non-nutritive suck (NNS) activity in tube-fed premature infants.MethodsA randomized trial to evaluate the efficacy of pneumatic orocutaneous stimulation 3x/day on NNS development and length of stay (LOS) in the NICU among 160 newborn infants distributed among 3 subpopulations, including healthy preterm infants (HI), respiratory distress syndrome (RDS), and chronic lung disease (CLD). Study infants received a regimen of orocutaneous pulse trains through a PULSED pressurized silicone pacifier or a SHAM control (blind pacifier) during gavage feeds for up to 10 days.ResultsMixed modeling, adjusted for the infant’s gender, gestational age, postmenstrual age, and birth weight, was used to handle interdependency among repeated measures within subjects. A significant main effect for stimulation mode (SHAM pacifier vs PULSED orosensory) was found among preterm infants for NNS Bursts/minute (p=.003), NNS events/minute (p=.033), and for Total Oral Compressions/minute [NNS+nonNNS] (p=.016). Pairwise comparison of adjusted means using Bonferroni adjustment indicated RDS and CLD infants showed the most significant gains on these NNS performance indices. CLD infants in the treatment group showed significantly shorter LOS by an average of 2.5 days.ConclusionFrequency-modulated PULSED orocutaneous pulse train stimuli delivered through a silicone pacifier are effective in facilitating NNS burst development in tube-fed RDS and CLD preterm infants, with an added benefit of reduced LOS for CLD infants.

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Section: Discussionmentioning

confidence: 51%

Frequency-modulated orocutaneous stimulation promotes non-nutritive suck development in preterm infants with respiratory distress syndrome or chronic lung disease

et al. 2013

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“…This broader stimulation spectrum may generate more effective sensory inputs in inducing neuroplastic changes in brainstem feeding centers and sensory and motor cortices [71. 72].…”

Section: Discussionmentioning

confidence: 99%

Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial

et al. 2019

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Objective To evaluate the effect of patterned, frequency-modulated oro-somatosensory stimulation on time to full oral feeds in preterm infants born 26–30 weeks gestation. Study design This is a multicenter randomized controlled trial. The experimental group (n = 109) received patterned, frequency-modulated oral stimulation via the NTrainer system through a pulsatile pacifier and the control group (n = 101) received a non-pulsatile pacifier. Intent-to-treat analysis (n = 210) was performed to compare the experimental and control groups and the outcomes were analyzed using generalized estimating equations. Time-to-event analyses for time to reach full oral feeds and length of hospital stay were conducted using Cox proportional hazards models. Results The experimental group had reduction in time to full oral feeds compared to the control group (-4.1 days, HR 1.37 (1.03, 1.82) p = 0.03). In the 29–30 weeks subgroup, infants in the experimental group had a significant reduction in time to discharge (-10 days, HR 1.87 (1.23, 2.84) p < 0.01). This difference was not observed in the 26–28 weeks subgroup. There was no difference in growth, mortality or morbidities between the two groups. Conclusions Patterned, frequency-modulated oro-somatosensory stimulation improves feeding development in premature infants and reduces their length of hospitalization. Trial registration ClinicalTrials.gov NCT01158391

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“…However, a rightward asymmetry has also been found to detect repetitive syllabic stimuli (Daneshvarfard et al 2019). Orocutaneous stimulation gave divergent results in terms of left (Barlow et al 2014) or right (Song et al 2014) dominance.…”

Section: Functional Asymmetries In Premature Infants Before Term Pcamentioning

confidence: 99%

Structural and functional brain asymmetries in the early phases of life: a scoping review

Bisiacchi

Cainelli

2021

Brain Struct Funct

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Asymmetry characterizes the brain in both structure and function. Anatomical asymmetries explain only a fraction of functional variability in lateralization, with structural and functional asymmetries developing at different periods of life and in different ways. In this work, we perform a scoping review of the cerebral asymmetries in the first brain development phases. We included all English-written studies providing direct evidence of hemispheric asymmetries in full-term neonates, foetuses, and premature infants, both at term post-conception and before. The final analysis included 57 studies. The reviewed literature shows large variability in the used techniques and methodological procedures. Most structural studies investigated the temporal lobe, showing a temporal planum more pronounced on the left than on the right (although not all data agree), a morphological asymmetry already present from the 29th week of gestation. Other brain structures have been poorly investigated, and the results are even more discordant. Unlike data on structural asymmetries, functional data agree with each other, identifying a leftward dominance for speech stimuli and an overall dominance of the right hemisphere in all other functional conditions. This generalized dominance of the right hemisphere for all conditions (except linguistic stimuli) is in line with theories stating that the right hemisphere develops earlier and that its development is less subject to external influences because it sustains functions necessary to survive.

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Modulation of EEG spectral edge frequency during patterned pneumatic oral stimulation in preterm infants

Cited by 8 publications

References 37 publications

Frequency-modulated orocutaneous stimulation promotes non-nutritive suck development in preterm infants with respiratory distress syndrome or chronic lung disease

Frequency-modulated orocutaneous stimulation promotes non-nutritive suck development in preterm infants with respiratory distress syndrome or chronic lung disease

Patterned frequency-modulated oral stimulation in preterm infants: A multicenter randomized controlled trial

Structural and functional brain asymmetries in the early phases of life: a scoping review

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