Modulation of EGFR and neu expression by n-6 and n-9 high-fat diets in experimental mammary adenocarcinomas

Moral, Raquel; Solanas, Montserrat; García, Gemma; Colomer, Ramon; Escrich, Eduard

doi:10.3892/or.10.5.1417

Cited by 23 publications

(34 citation statements)

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“…24 Furthermore a study on induced mammary tumors in the rat indicated that corn oil upregulates and olive oil downregulates the epidermal growth factor receptor and HER-2 signal transduction pathways in the tumor cells. 25 Thus the possibility arises that oleic acid, the main monounsaturated fatty acid of olive oil, may be largely responsible for the protective effect against HER-2-positive cancers.…”

Section: Discussionmentioning

confidence: 99%

Salad vegetables dietary pattern protects against HER‐2‐positive breast cancer: A prospective Italian study

Sant

Allemani

Sieri

et al. 2007

Intl Journal of Cancer

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Studies investigating the relation of diet to breast cancer have produced conflicting results. We hypothesized that dietary factors associated with breast cancer risk might differentially influence the HER-2 status of the cancers that develop, and investigated this hypothesis by analyzing the data of the ORDET prospective study. We analyzed 8,861 volunteer women residents of the Varese Province, Italy, for whom we had full data. By December 31, 2001, 238 cases had occurred in which HER-2 status was known. Four dietary patterns had been identified previously by factor analysis: salad vegetables (high consumption of raw vegetables and olive oil), prudent (cooked vegetables, poultry, fish), western (potatoes, meat, eggs, butter), and canteen (pasta, tomato sauce, wine). In our study, relative risks (RRs) of developing HER-2-positive and HER-2-negative breast cancers by tertiles of dietary pattern factor scores were assessed by multinomial logistic regression. The salad vegetables dietary pattern had a protective effect against HER-2-positive cancers (RR 5 0.25, 95% CI 0.10-0.64, for the highest tertile; p trend 5 0.001), much stronger than for HER-2-negative cancers (p heterogeneity 5 0.039). This important finding that a salad vegetables dietary pattern protects mainly against a specific breast cancer subtype indicates that future studies on environmental/dietary risk factors should explicitly take account of the heterogeneity of breast cancer phenotypes. ' 2007 Wiley-Liss, Inc.Key words: breast cancer; dietary pattern; HER-2The incidence of breast cancer varies markedly between countries, suggesting that dietary habits might be an important cause of this variation. A recent analysis of the ORDET (Hormones and Diet in Etiology of Tumors) cohort suggested that a dietary pattern characterized by high consumption of raw vegetables and olive oil may reduce breast cancer risk, especially in lean women (BMI < 25). 1 Other studies of dietary pattern have not shown such an association, 2 and epidemiologic studies on vegetable consumption and breast cancer have not provided clear results. 3,4 Etiological relationships between diet and breast cancer may have been masked by lack of consideration of cancer phenotype. Only a few studies have investigated associations between risk factors and cancer phenotype, most of which investigated the expression of receptors for estrogen and progesterone. 5-7 Studies considering HER-2 overexpression, which confers aggressivity [8][9][10] and is usually associated with an estrogen receptor-negative phenotype, 11 have been carried out mainly to investigate the relation of HER-2 overexpression to prognosis and response to treatment. 12 The relationship between etiologic risk factors and HER-2 overexpression has not been extensively investigated. It has been suggested that HER-2 overexpression bears little relation to the classic reproductive risk factors for breast cancer. 13 It is unclear, however, whether dietary factors can influence the biological characteristics of breast cancers, and t...

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Section: Discussionmentioning

confidence: 99%

Salad vegetables dietary pattern protects against HER‐2‐positive breast cancer: A prospective Italian study

Sant

Allemani

Sieri

et al. 2007

Intl Journal of Cancer

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“…Although a previous study showed that mammary adenocarcinoma induced by a lower dose of DMBA expressed mRNA of HER2 [32], in the mammary tumor induced by a higher dose of DMBA as in this study, the expression and immunohistochemical localization of HER2 were obscure. The interaction between HER2 positivity and the response to endocrine therapy in ER positive breast cancer has thus been disputed, and previous studies have repeatedly indicated an adverse interaction between HER2 positivity and endocrine therapy in ER positive breast cancer [3,9,16,47,48].…”

Section: Discussionmentioning

confidence: 40%

Characteristic Patterns of VEGF, Integrins, ER.ALPHA. and HER2 Immunoreactivity Suggest Two Tumor Cell Populations in DMBA-Induced Rat Mammary Tumor

Inoue

Kaidoh

Inoué

et al. 2005

Acta Histochem. Cytochem

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“…Thus, depending on the parameter studied, the high-olive oil diet exerted a weak stimulatory effect to a protective effect on mammary carcinogenesis. In all the experimental studies developed in our laboratory, the high-EVOO diet, in comparison with the HCO diet, consistently increased tumour latency (retarding the appearance of tumours) and decreased tumour incidence, multiplicity and volume (7,22,(30)(31)(32)(33) . Moreover, in some of the experimental series, we have observed that the olive oil diet reduced tumour content and volume, even in comparison with a control low-fat diet, which suggested a protective effect of the olive oil on mammary carcinogenesis (22,33) .…”

Section: Effects Of Extra Virgin Olive Oil On Experimental Breast Canmentioning

confidence: 99%

“…In sixteen experimental series developed in our laboratory, results have always been conclusive: diets with a high content of n-6 PUFA (corn oil) exert a clear stimulating effect of the experimental mammary carcinogenesis in all the clinical parameters studied (22,(27)(28)(29)(30)(31) (Fig. 1).…”

Section: Effects Of Extra Virgin Olive Oil On Experimental Breast Canmentioning

confidence: 99%

“…We found in experimental mammary tumours that the high-EVOO diet and the HCO diet had different influences on the modulation of the expression of the ErbB family of membrane receptors, especially c-erbB1. Hence, the HCO diet increased the ratio between the 9?5 kb mRNA of EGFR (coding the functional full-length receptor) and the 2?7 kb mRNA (coding an inactive truncated receptor), whereas the high-EVOO diet decreased this ratio in the mammary tumours (30) . On the other hand, the expression levels of p21Ras, a key transductor of ErbB proliferative signalling that is frequently involved in human mammary carcinogenesis (61) , were not modified by these dietary lipids (29) .…”

Section: Effects On Gene Expressionmentioning

confidence: 99%

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Olive oil, an essential component of the Mediterranean diet, and breast cancer

Escrich

Moral

Solanas

2011

Public Health Nutr.

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Objective: The Mediterranean diet has been related to a lower risk of some chronic diseases, including cancer. We aim to gain insight into the effects of the main source of fat of this diet on breast cancer, the most common type of malignancy in women. Design: Data from sixteen experimental series analysing the effects of dietary lipids on mammary carcinogenesis in an animal model, in the context of the international literature on the Mediterranean diet, olive oil and breast cancer risk. Setting: Experimental and human data on the effects of olive oil and Mediterranean diet on breast cancer. Subjects: An animal model of induced breast cancer and other human and experimental studies in the literature.Results: Diets rich in extra virgin olive oil (EVOO) exert a negative modulatory effect on experimental breast cancer to a weak promoting effect, much lower than that obtained with a high-corn oil diet. EVOO confers to the mammary adenocarcinomas a clinical behaviour and morphological features compatible with low tumour aggressiveness. This differential effect, in relation to other dietary lipids, may be related to a lower effect on body weight and sexual maturation. In addition, EVOO induced different molecular changes in tumours, such as in the composition of cell membranes, activity of signalling proteins and gene expression. All these modifications could induce lower proliferation, higher apoptosis and lower DNA damage. These results, together with the favourable effect of olive oil reported in the literature when it is consumed in moderate quantities, suggest a beneficial influence of EVOO on breast cancer risk. Conclusions: Consumption of EVOO in moderate quantities and throughout the lifetime appears to be a healthy choice and may favourably influence breast cancer risk.

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Modulation of EGFR and neu expression by n-6 and n-9 high-fat diets in experimental mammary adenocarcinomas

Cited by 23 publications

References 0 publications

Salad vegetables dietary pattern protects against HER‐2‐positive breast cancer: A prospective Italian study

Salad vegetables dietary pattern protects against HER‐2‐positive breast cancer: A prospective Italian study

Characteristic Patterns of VEGF, Integrins, ER.ALPHA. and HER2 Immunoreactivity Suggest Two Tumor Cell Populations in DMBA-Induced Rat Mammary Tumor

Olive oil, an essential component of the Mediterranean diet, and breast cancer

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