1997
DOI: 10.1046/j.1365-2249.1997.4301447.x
|View full text |Cite
|
Sign up to set email alerts
|

Modulation of Fas-mediated apoptosis of human thyroid epithelial cells by IgG from patients with Graves' disease (GD) and idiopathic myxoedema

Abstract: SUMMARYThe expression of two autoimmune thyroid diseases, GD and idiopathic myxoedema, is associated with antibodies to the thyroid-stimulating hormone (TSH) receptor. Thyroid stimulating antibodies (TSAb) in GD are TSH agonists and cause hyperthyroidism as well as goitre, whereas thyroid stimulation blocking antibodies (TSBAb) in idiopathic myxoedema are TSH antagonists and cause hypothyroidism and thyroid atrophy. We investigated the effect of antibodies to TSH receptor on Fas-mediated apoptosis of thyroid e… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

4
23
0
2

Year Published

1999
1999
2020
2020

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 31 publications
(29 citation statements)
references
References 28 publications
4
23
0
2
Order By: Relevance
“…3A). We found no difference in cell surface molecule expression and anti-Fasmediated apoptosis between Graves' thyrocytes and normal thyrocytes (data not shown), as we previously described Kawakami et al, 1997b;Matsuoka et al, 1996), including the effect of TSH for Fas-mediated apoptosis of thyrocytes shown later in this manuscript. Therefore, we used thyrocytes from Graves' patients in the following experiments.…”
Section: Kawakami Et Alsupporting
confidence: 79%
See 4 more Smart Citations
“…3A). We found no difference in cell surface molecule expression and anti-Fasmediated apoptosis between Graves' thyrocytes and normal thyrocytes (data not shown), as we previously described Kawakami et al, 1997b;Matsuoka et al, 1996), including the effect of TSH for Fas-mediated apoptosis of thyrocytes shown later in this manuscript. Therefore, we used thyrocytes from Graves' patients in the following experiments.…”
Section: Kawakami Et Alsupporting
confidence: 79%
“…As we previously described Kawakami et al, 1997b), anti-Fas-mediated apoptosis was detected only in IFN-␥-stimulated thy-…”
Section: Cell Surface Molecule Expression and Anti-fas-mediated Apoptsupporting
confidence: 58%
See 3 more Smart Citations