Modulation of fish immune response by interferon regulatory factor 4 in redlip mullet (Liza haematocheilus): Delineation through expression profiling, antiviral assay, and macrophage polarization analysis

Harasgama, J.C.; Kasthuriarachchi, T.D.W.; Sirisena, D.M.; Kwon, Hyukjae; Lee, Jehee; Wan, Qiang; Prabhatha, Madhuranga Walawedurage Srinith

doi:10.1016/j.dci.2022.104356

Cited by 3 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophage polarization was not only found in the mammalian system but also in the fish animals. In the redlip mullet ( Liza haematocheilus ) research, it was illustrated that Liza haematocheilus interferon regulatory factor 4 ( LhIRF4 ) can polarize the M0 to an alternative activation as M2-like macrophage ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Pan

Tsai

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

The water environment plays an important role in animal physiology. In this study, we sought to evaluate the effect of the acid environment on the Oreochromis niloticus (Nile tilapia) internal microenvironment immune response compare to the mouse macrophage model (J77A.1). The acid environment treated mouse macrophage J774A.1 model have shown that acidic treatment is able to polarize macrophages into M2-like macrophages via an increase in Ym1, Tgm2, Arg1, Fizz1, and IL-10 expression. Metabolic analysis of mouse macrophages (J774A.1) at pH 2 vs. pH 7 and pH 4 vs. pH 7 have been shown to promote the expression of intracellular acetylcholine, choline, prochlorperazine, L-leucine, and bisphenol A,2-amino-3-methylimidazo[4,5-f] quinolone metabolites in the M2-like macrophage. Immune gene expression of the O. niloticus spleen and liver treated at pH 2, 4, and 7 was shown to reduce TNF-α, IL-1 β, IL-8, and IL-12 expression compared to pH 7 treatment. Immune gene was induced in O. niloticus following culture at pH 5, 6, and 7 fresh water environment. Taken together, we found that the acid internal environment polarizes tissues into an M2 macrophage developmental microenvironment. However, if the external environment is acid, tissues are exposed to an M1 macrophage developmental microenvironment.

show abstract

Section: Introductionmentioning

confidence: 99%

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Pan

Tsai

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…However, high mortality from diseases caused by Lactococcus garvieae leads to substantial economic losses on mullet farms (Han et al, 2015). To date, several studies have been carried out on redlip mullet to understand the impact of L. garvieae on pathology and immune defense mechanisms (Harasgama et al, 2022). However, research on GSTs related with immune response in mullet has not yet been conducted.…”

Section: Introductionmentioning

confidence: 99%

Exploring the molecular characteristics, detoxification functions, and immune responses of two glutathione S-transferases in redlip mullet (Liza haematochelia)

Kim,

Omeka,

Wan

et al. 2024

Fish Aquat Sci

Self Cite

View full text Add to dashboard Cite

Interferon regulatory factors inhibit TiLV replication by activating interferon-a3 in tilapia (Oreochromis niloticus)

Ke,

Wen,

Wang

et al. 2024

Developmental & Comparative Immunology

View full text Add to dashboard Cite

Modulation of fish immune response by interferon regulatory factor 4 in redlip mullet (Liza haematocheilus): Delineation through expression profiling, antiviral assay, and macrophage polarization analysis

Cited by 3 publications

References 53 publications

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Acid external and internal environment exchange the Oreochromis niloticus tissue immune gene expression compared to the mouse macrophage polarization model

Exploring the molecular characteristics, detoxification functions, and immune responses of two glutathione S-transferases in redlip mullet (Liza haematochelia)

Interferon regulatory factors inhibit TiLV replication by activating interferon-a3 in tilapia (Oreochromis niloticus)

Contact Info

Product

Resources

About