Modulation of granulocyte functions by the influence of Aspergillus niger and Toll like receptor agonists in children suffering from cystic fibrosis

Bokonjić, Dejan; Vučević, Dragana; Minic, P.; Vasilijic, S.; Mihajlović, D; Čolić, Miodrag

doi:10.1016/s1526-0542(11)70106-3

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“…Studies performed ex vivo on granulocytes collected from the blood of patients with cystic fibrosis revealed modulation of their functions by Aspergillus niger . Granulocytes of these patients showed lower myeloperoxidase activity, lower phagocytosis and lower levels of apoptosis in culture, compared to healthy controls [ 6 ]. This may be responsible for higher susceptibility of these patients to Aspergillus infection.…”

Section: Discussionmentioning

confidence: 99%

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Negative correlation between mycological surfaces pollution in hospital emergency departments and blood monocytes phagocytosis of healthcare workers

Lewicki¹,

Bielawska-Drózd²,

Winnicka³

et al. 2015

cejoi

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The aim of the present study was to find a possible relationship between the presence of yeast and filamentous fungi in hospital emergency departments and the activity levels of blood granulocytes and monocytes in emergency personnel.The study of mycological pollution was conducted in winter; the samples were collected from 10 Warsaw hospitals emergency departments (HE D) and in 10 control locations (office spaces) and included air samples and swabbing of floor and walls. The blood for immunological investigation was taken in spring, from 40 men, 26 to 53 years old, healthcare workers of these departments, who have been working for at least 5 years in their current positions, and from 36 corresponding controls, working in control offices. Evaluation of blood leukocyte subpopulations was done by hematological analyzer and cytometry analysis and monocyte and granulocyte phagocytosis by Phagotest.There were no significant differences in the level of mycological contamination between the test and control places. The qualitative analysis of the surfaces and air samples revealed a prevalence of strains belonging to Aspergillus spp. and Penicillium spp. genus.Statistical analysis revealed the existence of negative correlation between the number of phagocytizing blood monocytes and fungi spores content on floor and wall surfaces in hospital emergency departments (r = –0.3282, p < 0.05 and positive correlation between the number of phagocytizing monocytes in the blood of office workers and fungi pollution of control offices (r = 0.4421, p < 0.01).

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Section: Discussionmentioning

confidence: 99%

“…Polymorphonuclear granulocytes (G) and mononuclear phagocytes: monocytes and macrophages (M) may play a crucial role in the defense against fungal infections. However, fungi and their products may directly or indirectly inhibit their microbiocidal activity [ 1 – 6 ].…”

Section: Introductionmentioning

confidence: 99%