Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Dasriya, Vaishali Lekchand; Samtiya, Mrinal; Ranveer, Soniya; Dhillon, Harmeet Singh; Devi, Nishu; Sharma, Vikas; Nikam, Pranali; Puniya, Monica; Chaudhary, Priya; Chaudhary, Vishu; Behare, Pradip V; Dhewa, Tejpal; Vemuri, Ravichandra; Raposo, António; Puniya, Dharun Vijay; Khedkar, Gulab D.; Vishweswaraiah, Raghu Hrikyathahalli; Vij, Shilpa; Alarifi, Sehad N; Han, Heesup; Puniya, Anil Kumar

doi:10.1002/jsfa.13370

Cited by 16 publications

(5 citation statements)

References 201 publications

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“…Dietary and therapeutic response: Dietary components directly affect the composition and activity of gut microbiota, thereby affecting the host’s nutritional metabolism ( 34 ). Specific dietary patterns, such as those rich in dietary fiber, antioxidants, or anti-inflammatory foods, may enhance the body’s response to chemotherapy drugs, radiation therapy, or ICI therapy by optimizing the gut microbiota, reducing therapeutic toxicity ( 35 – 37 ).…”

Section: The Mutual Regulatory Effect Between Gut Microbiota and The ...mentioning

confidence: 99%

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Zhang,

Hong,

et al. 2024

Front. Immunol.

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Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays a certain role in GBM, and can directly or indirectly affect the efficacy of immune checkpoint inhibitors (ICIs) in various ways. (1) The metabolites produced by gut microbiota directly affect the host’s immune homeostasis, and these metabolites can affect the function and distribution of immune cells, promote or inhibit inflammatory responses, affect the phenotype, angiogenesis, inflammatory response, and immune cell infiltration of GBM cells, thereby affecting the effectiveness of ICIs. (2) Some members of the gut microbiota may reverse T cell function inhibition, increase T cell anti-tumor activity, and ultimately improve the efficacy of ICIs by targeting specific immunosuppressive metabolites and cytokines. (3) Some members of the gut microbiota directly participate in the metabolic process of drugs, which can degrade, transform, or produce metabolites, affecting the effective concentration and bioavailability of drugs. Optimizing the structure of the gut microbiota may help improve the efficacy of ICIs. (4) The gut microbiota can also regulate immune cell function and inflammatory status in the brain through gut brain axis communication, indirectly affecting the progression of GBM and the therapeutic response to ICIs. (5) Given the importance of gut microbiota for ICI therapy, researchers have begun exploring the use of fecal microbiota transplantation (FMT) to transplant healthy or optimized gut microbiota to GBM patients, in order to improve their immune status and enhance their response to ICI therapy. Preliminary studies suggest that FMT may enhance the efficacy of ICI therapy in some patients. In summary, gut microbiota plays a crucial role in regulating ICIs in GBM, and with a deeper understanding of the relationship between gut microbiota and tumor immunity, it is expected to develop more precise and effective personalized ICI therapy strategies for GBM, in order to improve patient prognosis.

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Section: The Mutual Regulatory Effect Between Gut Microbiota and The ...mentioning

confidence: 99%

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Zhang,

Hong,

et al. 2024

Front. Immunol.

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“…The immune cells are stimulated via regulation of gene expression and signaling pathways in the host cells which results in macrophage activation and enhanced phagocytosis [63]. Another mechanism by which probiotics exert their health benefits on the host is by the production of antimicrobial agents or compounds such as bacteriocins which exert competitive exclusion of pathogens [64]; improving the digestion and absorption of food [65,66]; as well as alteration of the intestinal microflora [67,68]. As earlier mentioned, probiotics are live microorganisms which when administered in adequate quantity exert or confer a health benefit on the host [69] and Lactobacillus and Bifidobacteriumspecies are the most commonly used.…”

Section: Mechanisms Of Action Of Probiotics In the Bodymentioning

confidence: 99%

Fermented African Locust Bean (Iru), a Potential Dietary Prebiotic and Probiotic

Adeniyi

2024

IJNFS

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The fact that indigenous foods in Nigeria are always forgotten as possible dietary prebiotics and probiotics cannot be overemphasized, hence, there is need to bring to limelight the potentials of our indigenous foods that are potent prebiotics and probiotics. This is therefore a review of prebiotic and probiotic concept, food sources with emphasis on iru, fermented African locust bean. The search engines used for this study are; Google Scholar, AGORA and HINARI. The Galactose-oligosaccharide and arabinogalactan which are the prebiotics in African locust bean (Parkiabiglobosa) can be partially hydrolyzed in the course of fermentation of the bean into iru while the unhydrolyzed part acts as a prebiotic when the condiment is consumed. This makes iru a possible source of prebiotic. In the same vein Bacillus spp and Lactobacillus spp which are probiotics dominate the fermentation procedure in the production of iru and they were affirmed to be acid tolerant, thermotolerant, bile salt tolerant with appreciable or notable antibacterial activity against gastrointestinal pathogens. Fermented African locust bean, Iru, indeed has potentials of dietary prebiotic and probiotic, hence, its consumption should be optimally and maximally encouraged, popularized and publicized in order to harness the nutritious, aromatic and health benefits of this indigenous culinary condiment.

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“…Following the First and Second World Wars, the population's nutritional intake changed and, consequently, consumption of ultra-processed food increased as did sedentary lifestyles; both were responsible for a decline in health and quality of life. Such a decrease in nutritional quality directly affects bacterial intestinal metabolism and its local microbiota, leading to metabolic conditions such as obesity, diabetes, and heart and liver diseases [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…In parallel, emerging scientific knowledge concerning health and disease modulation by the microbiota and its several metabolites is focused on the so-called "brain-gut axis"; 2 of 34 thus, the interruption of its healthy and effective communication results in a number of diseases associated with inflammation, cardiovascular risks, obesity, type 2 diabetes (DM2), and other endocrine pathologies, such as hypothyroidism and polycystic ovary syndrome [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

De Cól,

de Lima,

Pompeu

et al. 2024

IJMS

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Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and fatty liver dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, and metabolic syndrome are frequently present; these conditions are related to liver lipogenesis and systemic inflammation. This study aimed to review the connection between the brain–gut–liver axis and MAFLD. The inflammatory process, cellular alterations in hepatocytes and stellate cells, hypercaloric diet, and sedentarism aggravate the prognosis of patients with MAFLD. Thus, to understand the modulation of the physiopathology of MAFLD, it is necessary to include the organokines involved in this process (adipokines, myokines, osteokines, and hepatokines) and their clinical relevance to project future perspectives of this condition and bring to light new possibilities in therapeutic approaches. Adipokines are responsible for the activation of distinct cellular signaling in different tissues, such as insulin and pro-inflammatory cytokines, which is important for balancing substances to avoid MAFLD and its progression. Myokines improve the quantity and quality of adipose tissues, contributing to avoiding the development of MAFLD. Finally, hepatokines are decisive in improving or not improving the progression of this disease through the regulation of pro-inflammatory and anti-inflammatory organokines.

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Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health

Cited by 16 publications

References 201 publications

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Fermented African Locust Bean (Iru), a Potential Dietary Prebiotic and Probiotic

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

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