Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

Shehata, Abdelrazeq M.; Saadeldin, Islam M.; Tukur, Hammed A.; Habashy, Walid S.

doi:10.3390/ani10122407

Cited by 51 publications

(35 citation statements)

References 179 publications

(294 reference statements)

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“…Under various stress conditions including physiological stress, heat shock proteins such as HSP70 are expected to be highly expressed as an endogenous protection mechanism to maintain cellular hemostasis and prevent apoptotic processes [ 43 ]. Noteworthy, the measurement of this gene was unaltered in the current study by either diet or DEX challenge.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Barekatain

Chalvon‐Demersay

McLaughlan

et al. 2021

Animals

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Two experiments were conducted to investigate the effect of arginine (Arg); the combination of Arg and glutamine (Gln); as well as an amino acid-based solution (MIX) containing Arg, Gln, threonine (Thr), and grape extract, on performance, intestinal permeability, and expression of selected mechanistic genes. Using 240 male Ross 308 off-sex broiler chickens, four experimental treatments were replicated six times with 10 birds per replicate. The experimental treatments included 5 g/kg Arg, 2.5 g/kg Arg and 2.5 g/kg Gln, and 1 g/kg MIX added to a basal diet as control. In the second study, the four dietary treatments were then given to 24 birds with or without a synthetic glucocorticoid, dexamethasone (DEX), as a gut dysfunction model. Feed conversion ratio was improved by all the supplemented treatments from day 7 to 35 of age (p < 0.001). DEX injections increased (p < 0.001) the intestinal permeability in all treatments, which tended to be reversed by Arg or MIX. Additional Arg, Arg-Gln, and MIX suppressed (p < 0.05) the overexpression of IL-1β generated by DEX. Feeding birds with MIX treatment increased (p < 0.05) expression of SGLT-1 and glutathione synthetase. In conclusion, tested amino acid supplements were effective in improving feed efficiency and restraining intestinal inflammation caused by DEX through IL-1β pathway.

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Section: Discussionmentioning

confidence: 99%

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Barekatain

Chalvon‐Demersay

McLaughlan

et al. 2021

Animals

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“…HSPs are grouped based on their molecular weights. Among HSP classes, HSP60, HSP70, and HSP90 are mostly studied (Shehata et al, 2020).…”

Section: Heat Stressmentioning

confidence: 99%

Environmental Stress in Chickens and the Potential Effectiveness of Dietary Vitamin Supplementation

Akinyemi

Adewole

2021

Front. Anim. Sci.

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Environmental stressors can promote the vulnerability of animals to infections; it is therefore, essential to understand how stressors affect the immune system, the adaptive capacity of animals to respond, and effective techniques in managing stress. This review highlights scientific evidence regarding environmental stress challenge models and the potential effectiveness of vitamin supplementation. The major environmental stressors discussed are heat and cold stress, feed restriction, stocking density, and pollutants. Much work has been done to identify the effects of environmental stress in broilers and layers, while few involved other types of poultry. Studies indicated that chickens' performance, health, and welfare are compromised when challenged with environmental stress. These stressors result in physiological alterations, behavioral changes, decreased egg and meat quality, tissue and intestinal damage, and high mortalities. The application of vitamins with other nutritional approaches can help in combating these environmental stressors in chickens. Poultry birds do not synthesize sufficient vitamins during stressful periods. It is therefore suggested that chicken diets are supplemented with vitamins when subjected to environmental stress. Combination of vitamins are considered more efficient than the use of individual vitamins in alleviating environmental stress in chickens.

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“…When chickens experience heat stress, there is an increase in body temperature (hyperthermia) that might cause protein folding disorders [ 16 , 17 ]. Therefore, the role of heat shock protein (HSP) compounds is essential.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the role of heat shock protein (HSP) compounds is essential. HSP compounds can act as molecular chaperones and function as shields for certain proteins through intracellular membranes [ 8 , 17 ]. The presence of HSP compounds when there is an increase in heat stress is the body's effort to protect proteins that are sensitive to temperature changes [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Expression of the HSP70 molecule is found in almost all body tissues to protect cell damage from heat stress by maintaining denatured protein folds and preventing cellular apoptosis [ 19 ]. HSP70 has a cytoprotective role during heat stress exposure [ 17 , 20 ]. There is a strong correlation between chicken genotype and HSP70 genotype with the ability of chickens to withstand heat exposure [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure

Sugito

Etriwati

Akmal

et al. 2021

The Scientific World Journal

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The administration of plant extracts to broilers may be a way to mitigate the effects of heat stress. The importance of AQP2 and HSP70 compounds in maintaining the homeostasis of the chicken body when it is subjected to heat stress is well established. This study aims to determine the effect of giving the ethanolic extract of the leaves of Salix tetrasperma Roxb. on the immunohistochemical expression of AQP2 and HSP70 in exposed and unexposed broiler kidney tissue. This study used 36 samples of 28-day-old chicken kidneys. Chickens were kept in individual cages, provided with feed and drinking water ad libitum. The design used was a completely randomized design with 6 treatments and 6 replications: (a) chickens were reared in conditions exposed to heat (HS + 0); (b) chickens were reared in conditions exposed to heat and given Salix extract at a dose of 50 mg/L drinking water (HS + 50); (c) chickens were reared under heat-exposed conditions and given Salix extract at a dose of 100 mg/L drinking water (HS + 100); (d) chickens were reared in conditions without exposure to heat (n-HS + 0); (e) chickens were reared in conditions without exposure to heat and given Salix extract at a dose of 50 mg/L drinking water (nHS + 50); and (f) chickens were reared in conditions exposed without exposure to heat and given 100 mg/L drinking water (nHS + 100) of Salix extract. Salix extract was given for 24 hours and was renewed every 6 hours. The results showed that giving Salix extract 100 mg/L in drinking water to chickens exposed to heat (HS + 100) reduced the value of the H/L ratio. Giving Salix extract 50–100 mg/L in drinking water caused an upregulated AQP2 expression; on the other hand, it downregulated HSP-70 expression, in chicken kidney tubules both exposed to heat stress and nonexposed to heat stress. In conclusion, exposure to heat stress in broiler chickens and giving Salix extract can increase the formation of aquaporin 2 compounds and suppress the formation of HSP70.

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Modulation of Heat-Shock Proteins Mediates Chicken Cell Survival against Thermal Stress

Cited by 51 publications

References 179 publications

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Intestinal Barrier Function and Performance of Broiler Chickens Fed Additional Arginine, Combination of Arginine and Glutamine or an Amino Acid-Based Solution

Environmental Stress in Chickens and the Potential Effectiveness of Dietary Vitamin Supplementation

Immunohistochemical Expression of AQP2 and HSP70 in Broiler Kidney Tissue Treated with Salix tetrasperma Roxb. Extract under Heat Exposure

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