Modulation of Heidelberg Retinal Flowmeter Parameter Flow at the Papilla of Healthy Subjects

Haefliger, Ivan O.; Lietz, Andrea; Griesser, S.; Ulrich, A; Schötzau, Andreas; Hendrickson, Phillip; Flammer, Josef

doi:10.1016/s0039-6257(99)00025-9

Cited by 38 publications

(23 citation statements)

References 16 publications

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“…A number of studies have addressed the role of b-blockers on ocular blood flow (OBF). [19][20][21][22] Reports on the effect of timolol, a non-selective, topical b-blocker that lowers IOP through the reduction of aqueous humour production on OBF, are contradictory. Almost half of the patients treated with timolol require combination therapy to control IOP and glaucomatous damage.…”

Section: Introductionmentioning

confidence: 99%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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Purpose To compare the effect of dorzolamide hydrochloride 2%, timolol maleate 0.5%, and their fixed combination on intraocular pressure (IOP) and retinal and optic nerve head haemodynamics in primary open-angle glaucoma patients. Methods Twenty-eight patients with early-moderate glaucomatous damage treated with b-blockers (46 months) with IOP values ranging from 18 to 22 mmHg at trough participated in this trial. After a 4-week washout period, patients were randomized in two groups: group I started with dorzolamide 2% monotherapy and group II with timolol 0.50% monotherapy for 4 weeks. After this period, both groups switched to dorzolamide/ timolol fixed combination for 4 weeks. IOP, ocular diastolic perfusion pressure (ODPP), heart rate, and Scanning Laser Doppler Flowmetry measurements at the peripapillary retina and neuroretinal rim were taken at T0 (enrolment), T1 (wash out), T2 (monotherapy), and T3 (dorzolamide/timolol). Data were compared between different study times. Statistical analysis was conducted using a paired t-test. Results Between T1 and T3, IOP decreased significantly in group I (À21.40%) (Po0.001) and in group II (À21.25%) (Po0.001). At the same time intervals, blood flow increased significantly at rim level for group I ( þ 30.03%) (Po0.05) and also when all patients were considered (rim þ 17.99%) (Po0.05). Between T1 and T3, we also observed a significant increase of ODPP in group I ( þ 7.24%) (Po0.01) and in group II ( þ 6.08%) (Po0.05) and when all patients were considered ( þ 8.43%) (Po0.01). Conclusions Dorzolamide/timolol fixed combination increased blood flow significantly at the neuroretinal rim showing a combination of hypotensive and haemodynamic effects.

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Section: Introductionmentioning

confidence: 99%

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Rolle

Tofani

Brogliatti

et al. 2008

Eye

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“…After approval of the study protocol by the ethics committee of the Vienna University School of Medicine and after written informed consent was obtained, 25 healthy male volunteers were enrolled in the study (mean age 25 (SD 3) years, range [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Thirteen participants had been smokers for at least two years and regularly smoked between 15 and 25 cigarettes per day.…”

Section: Subjectsmentioning

confidence: 99%

Response of choroidal blood flow to carbogen breathing in smokers and non-smokers

Wimpissinger

Resch²,

Berisha³

et al. 2004

British Journal of Ophthalmology

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Aim: To investigate a potential difference in ocular vascular reactivity during carbogen breathing in optic nerve head, choroid, and retina between healthy smokers and nonsmokers. Methods: 25 (13 smokers and 12 non-smokers) healthy male volunteers participated in this observer masked, two cohort study. During inhalation of carbogen (5% CO 2 and 95% O 2 ) over 10 minutes measurements were taken using laser Doppler flowmetry to assess submacular choroidal and optic nerve head blood flow, laser interferometry to assess fundus pulsation amplitudes, and retinal vessel analyser (RVA) to assess retinal vessel diameters. Results: At baseline choroidal blood flow was higher (p = 0.018, ANOVA) in smokers than in non-smokers. During administration of carbogen the response in choroidal blood flow was significantly different between the two groups: there was an increase in non-smokers after carbogen breathing (p = 0.048) compared with relatively stable blood flow in smokers (p = 0.049 between groups, ANOVA). A similar response pattern was seen for fundus pulsation amplitude, which increased notably after carbogen breathing in non-smokers but not in smokers (p,0.001 between groups, ANOVA). Optic nerve head blood flow and retinal vessel diameters were reduced in both groups to a comparable degree during carbogen breathing. Conclusion: The study indicated abnormal choroidal vascular reactivity in chronic smokers. These early haemodynamic changes may be related to the increased risk to smokers of developing ocular vascular diseases. The specific mechanisms underlying abnormal choroidal vascular reactivity in chronic smokers remain to be characterised.

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“…There has been no report regarding the effects of travoprost, bimatoprost or tafluprost on ONH blood flow in humans as far as we know. It is reported that timolol either had no significant effect on or decreased ONH blood flow in humans (Yoshida et al, 1991;Tamaki et al, 1997aTamaki et al, , 1997bNetland et al, 1999;Haefliger et al, 1999;Lübeck et al, 2001). In contrast, carteolol, betaxolol and nipradilol reportedly increased ONH blood flow in humans (Tamaki et al, 1997a(Tamaki et al, , 1997bTamaki et al, 1999;Mizuno et al, 2002).…”

Section: Introductionmentioning

confidence: 98%

Optic Nerve Head Blood Flow in Glaucoma

Sugiyama¹,

Shibata²,

Kojima³

et al. 2011

The Mystery of Glaucoma

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Modulation of Heidelberg Retinal Flowmeter Parameter Flow at the Papilla of Healthy Subjects

Cited by 38 publications

References 16 publications

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients

Response of choroidal blood flow to carbogen breathing in smokers and non-smokers

Optic Nerve Head Blood Flow in Glaucoma

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