Modulation of Immune Response by Blood Transfusion: Evidence for a Differential Effect of Allogeneic and Autologous Blood in Colorectal Cancer Surgery

Heiss, M. M.; Fraunberger, Peter; Delanoff, Christian; Stets, Regine; Allgayer, Heike; Ströhlein, Michael A.; Tarabichi, Anwar; Faist, Eugen; Jauch, Karl Walter; Schildberg, F. W.

doi:10.1097/00024382-199712000-00002

Cited by 69 publications

(50 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tissue injury itself, but also anesthesia and blood transfusion, have been shown to compromise host immune functions. [25][26][27] In the present study, it is possible that a cumulative effect of these immunosuppressive events has led to different degrees of depressed immune responses after THE versus TTE.…”

Section: Van Sandick and Othersmentioning

confidence: 78%

Immune Responses and Prediction of Major Infection in Patients Undergoing Transhiatal or Transthoracic Esophagectomy for Cancer

Sandick¹,

Gisbertz²,

Berge³

et al. 2003

Annals of Surgery

View full text Add to dashboard Cite

ObjectiveTo investigate alterations in immune responses after transhiatal versus transthoracic esophageal resection and to evaluate the role of preoperative immune functions in predicting postoperative infectious complications. Summary Background DataImpaired immune defense is associated with a decreased resistance to infection. Patients undergoing esophageal resection via a transhiatal or transthoracic approach are prone to develop infectious complications. There are no randomized data on immune responses after two major surgical interventions. MethodsThe study group consisted of 20 patients who were randomly allocated to a limited transhiatal or extended transthoracic esophagectomy for cancer. Blood samples were taken before the operation and at regular intervals thereafter from day 1 to day 10. Monocyte and T-helper type 1 (Th1) and type 2 (Th2) lymphocyte functions were assessed in stimulated whole blood cultures.

show abstract

Section: Van Sandick and Othersmentioning

confidence: 78%

Immune Responses and Prediction of Major Infection in Patients Undergoing Transhiatal or Transthoracic Esophagectomy for Cancer

Sandick¹,

Gisbertz²,

Berge³

et al. 2003

Annals of Surgery

View full text Add to dashboard Cite

show abstract

“…Moreover, the excessive tissue damage and handling of the patient during anesthesia and blood transfusion can be effective in infection after esophagectomy (46,47). Many studies have shown that Trans-Hiatal and Transthoracic techniques significantly reduce the level of safety (48,49).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Early and Late Complications in Three Esophagectomy Techniques

Mousavi¹,

Akbari²

2017

Int J Cancer Manag

View full text Add to dashboard Cite

Background: Due to the high prevalence and mortality rates of esophageal cancer in some parts of the world and considering that in most patients, symptoms occur when cancer is advanced, this study aimed to compare early and late complications in three esophagectomy techniques for treatment of esophageal cancer. Methods: The present study was a descriptive research on 316 patients with esophageal cancer referring to Shohada Tajrish hospital, Tehran. The results were recorded in the research forms consisting of individual characteristics, symptoms and reasons for referring to the hospital. Findings were extracted after classification and evaluated using descriptive statistics. Results: Among 316 patients studied, 190 patients (60%) were male and 126 (40%) were female. The highest prevalence was between 40 and 60 years old. The most significant reason for referring to the hospital was dysphagia and weight loss. Among 260 patients, 72 patients (27.7%) underwent surgery by transthoracic (Ivor Lewis type) approach, 76 patients (29.2%) underwent surgery by threeincision approach (Mc Keown procedure), and 112 patients (43%) underwent surgery by Trans-Hiatal (Oringer). A total of 36 deaths occurred. 22 deaths occurred using Ivor-Lewis (61%), 10 deaths occurred using Mc Keown (27.7%) and 4 deaths occurred after Oringer (11.1%). In terms of prevalence of complications, the most common early complication was pleural effusion (11%) and the most common late complication was anastomotic stricture (17.8%). Conclusions:Complications occurred in all three surgeries. The most complications occurred using transthoracic (Ivor Lewis type) approach and the least complications occurred using Trans-Hiatal (Oringer).

show abstract

“…Contamination of red cells, especially with prolonged storage, is a constant worry, as is the somewhat greater risk of postoperative infections in heavily transfused patients (Blajchman, 1997). It has long been recognized that transfused blood can suppress the immune system (Heiss et al, 1997). This may be an advantage in the case of graft survival (Opelz et al, 1973).…”

Section: Other Risks Of Blood Transfusionmentioning

confidence: 99%

Blood substitutes: refocusing an elusive goal

Winslow¹

2000

Br J Haematol

View full text Add to dashboard Cite

Modulation of Immune Response by Blood Transfusion: Evidence for a Differential Effect of Allogeneic and Autologous Blood in Colorectal Cancer Surgery

Cited by 69 publications

References 0 publications

Immune Responses and Prediction of Major Infection in Patients Undergoing Transhiatal or Transthoracic Esophagectomy for Cancer

Immune Responses and Prediction of Major Infection in Patients Undergoing Transhiatal or Transthoracic Esophagectomy for Cancer

Comparison of Early and Late Complications in Three Esophagectomy Techniques

Blood substitutes: refocusing an elusive goal

Contact Info

Product

Resources

About