Modulation of Immune System by Carbon Nanotubes

Ilves, Marit; Alenius, Harri

doi:10.1002/9783527692866.ch13

Cited by 5 publications

(5 citation statements)

References 93 publications

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“…As an example, for mimicking inhalation exposure, ENM are delivered in several studies dispersed in a liquid forcefully introduced within the respiratory tree, which is a quite different situation in comparison to the expected exposure in humans. However, recent observations with MWCNT suggest that oropharyngeal aspiration, provided that appropriate doses are used, can serve as a highly useful and reliable surrogate for inhalation exposure (Ilves & Alenius, 2016). In theory, inhalation, or in some cases oropharyngeal aspiration, exposure may in most cases represent the best method for performing reliable acute toxicity studies via the pulmonary route.…”

Section: Short-term Exposurementioning

confidence: 99%

“…Especially certain types of metal and metal oxide nanoparticles frequently induce inflammation and even genotoxicity, but their potential to induce harmful morphological permanent changes in their target organ is often quite limited (Fu et al, 2014). However, fibrous materials such as different types of CNT, especially rigid rod-like CNT, readily induce genotoxicity and have proven to be carcinogenic to rodents (Catalán et al, 2016;Ilves & Alenius, 2016;Kinaret et al, 2017;Palomäki et al, 2011). Evidence of carcinogenicity of Mitsui-7 MWCNT is compelling from experimental animal studies which has lead IARC to classify Mitsui-7 as a possible human carcinogen (Grosse et al, 2014).…”

Section: Implications For Human Health From Experimental Studiesmentioning

confidence: 99%

“…Currently, the ability of various methods to predict toxicity of various materials is very limited and hence these results should be interpreted with a caution. However, new approaches, utilizing transcriptomics and proteomic methods and bioinformatics are emerging and may be able to provide new possibilities to predict the toxicity of different types of ENM (Ilves & Alenius, 2016;Kinaret et al, 2017). Before such approaches are fully available, one has to execute ENM risk assessment based on the current material by material approach.…”

Section: Implications For Human Health From Experimental Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Nanomaterial exposure, toxicity, and impact on human health

Pietroiusti¹,

Stockmann-Juvala

Lucaroni³

et al. 2018

WIREs Nanomed Nanobiotechnol

175

120

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The use of engineered nanomaterials (ENM) has grown after the turn of the 21st century. Also, the production of ENM has globally grown, and exposure of workers especially via the lungs to ENM has increased. This review tackles with effects of ENM on workers’ health because occupational environment is the main source of exposure to ENM. Assessment of exposure to ENM is demanding, and today there are no occupational exposure level (OEL) for ENM. This is partly due to challenges of such measurements, and in part to the unknown causality between ENM metrics and effects. There are also marked gaps in systematic knowledge on ENM hazards. Human health surveys of exposed workers, or human field studies have not identified specific effects of ENM linking them with a specific exposure. There is, however, a consensus that material characteristics such as size, and chemistry influence effects of ENM. Available data suggest that multiwalled carbon nanotubes (MWCNT) affect the immunological system and cause inflammation of the lungs, or signs of asthma whereas carbon nanofibers (CNF) may cause interstitial fibrosis. Metallic and metal oxide nanoparticles together with MWCNT induce genotoxicity, and a given type of MWCNT has been identified as a possible human carcinogen. Currently, lack of understanding of mechanisms of effects of ENM renders assessment of hazards and risks of ENM material‐by‐material a necessity. The so called “omics” approaches utilizing ENM‐induced alterations in gene and protein expression may be useful in the development of a new paradigm for ENM hazard and risk assessment. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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Section: Short-term Exposurementioning

confidence: 99%

Section: Implications For Human Health From Experimental Studiesmentioning

confidence: 99%

Section: Implications For Human Health From Experimental Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterial exposure, toxicity, and impact on human health

Pietroiusti¹,

Stockmann-Juvala

Lucaroni³

et al. 2018

WIREs Nanomed Nanobiotechnol

175

120

View full text Add to dashboard Cite

show abstract

“…While food allergen management uses nanotechnology (Kumar et al., 2012; Pilolli et al., 2013), there is some evidence that nanoparticles can increase allergic inflammation (Ilves & Alenius, 2016; Syed et al., 2013; Yoshida et al., 2011). Nanomaterial exposure frequently produces an inflammatory response and increased ROS production.…”

Section: Risk Analysismentioning

confidence: 99%

Advancements in nanotechnology for food science and industry

Jagtiani

2021

Food Frontiers

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The food industry will be impacted by the acceleration of nanotechnology, its creative applications and constant advancements. Nanostructured materials are utilized to encapsulate food components, packaging and nanosensors. These materials make the compound more soluble, bioavailable and increase its delivery speed, while also keeping the active components safe throughout production and storage. The review outlines the effects of nanotechnology on food systems and describes the outcomes of antimicrobial nanostructural materials on bacteria. It also highlights the characteristics of food‐nanotechnology along with its existing and possible future applications in food science. The potential for nanoparticles to be used in the food industry to supply customers with safe, contaminant‐free food and to increase the acceptance of the food due to its enhanced functional characteristics has been summarized as well.

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“…Nanotechnology is being developed and used to advance food-allergen management by several researchers (Pilolli, et al , 2013; Kumar et al , 2012). Several researchers Yoshida et al (2011), Ilves and Alenius (2016), Syed et al (2013) have worked on nano-materials and allergic pulmonary inflammation. Previous studies by Syed et al (2013) have revealed that human exposure to nano-materials could result in inflammatory response and increased ROS production.…”

Section: Nanotechnology and Food Safetymentioning

confidence: 99%

Food packaging and nanotechnology: safeguarding consumer health and safety

Albanie

2019

NFS

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Purpose Nanotechnology as an emerging area if adequately harnessed could revolutionise food packaging and food processing industry worldwide. Although several benefits of nano-materials or particles in food packaging have been suggested, potential risks and health hazards of nano-materials or particles are possible as a result of migration of their particles into food materials. The purpose of this review therefore assessed nanotechnology and its applications in food packaging, consumer acceptability of nano-packaged foods and potential hazards and safety issues in nano-packaged foods. Design/methodology/approach This review takes a critical assessment of previous literature on nanotechnology and its impact on food packaging, consumer health and safety. Findings Applications of nanotechnology in food packaging could be divided into three main divisions: improved packaging, which involves mixing nano-materials into polymers matrix to improve temperature, humidity and gas barrier resistance of the packaging materials. Active packaging deals with direct interaction between nano-materials used for packaging and the food to protect it as anti-microbial or oxygen or ultra violet scavengers. Smart packaging could be used to sense biochemical or microbial changes in foods, as well as a tracker for food safety, to prevent food counterfeit and adulteration. The review also discussed bio-based food packaging which is biodegradable. Bio-based packaging could serve as veritable alternative to conventional packaging which is non-degradable plastic polymers which are not environmental friendly and could pose a threat to the environment. However, bio-based packaging could reduce material waste, elongate shelf life and enhance food quality. However, several challenges are envisaged in the use of nano-materials in food packaging due to knowledge gaps, possible interaction with food products and possible health risks that could result from the nano-materials used for food packaging. Originality/value The increase in growth and utilisation of nanotechnology signifies wide use of nano-materials especially in the food sector with arrays of potential benefits in the areas of food safety and quality, micronutrients and bioactive ingredients delivery, food processing and in packaging Active studies are being carried out to develop innovative packages such as smart, intelligent and active food packaging to enhance effective and efficient packaging, as well as balanced environmental issues. This review looks at the future of nano-packaged foods vis-à-vis the roles played by stakeholders such as governments, regulatory agencies and manufacturers in looking into consumer health and safety issues related to the application of nano-materials in food packaging.

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Modulation of Immune System by Carbon Nanotubes

Cited by 5 publications

References 93 publications

Nanomaterial exposure, toxicity, and impact on human health

Nanomaterial exposure, toxicity, and impact on human health

Advancements in nanotechnology for food science and industry

Food packaging and nanotechnology: safeguarding consumer health and safety

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