Modulation of immune tolerance with a Chinese traditional prescription inhibits allergic rhinitis in mice

Protective effect of Bojungikki-tang, a traditional herbal formula, against alcohol-induced gastric injury in rats

“…This formula has been identified as an effective drug for improving function of the digestive system and for strengthening the defensive defenses against various infections in Asia. Immunomodulatory effects of Bojungikki-tang include decreases in the recurrent attack rate of allergic rhinitis (Xie et al, 2011), decrease in IgE levels in animal models of atopic dermatitis (Kobayashi et al, 2003), antibacterial effect against Helicobacter pylori infection in mice (Yan et al, 2002), suppression of chronic contact hypersensitivity (Nakada et al, 2002), suppression of collagen-induced arthritis in mice (Hai et al, 2002), radioprotective effects in mice (Kim et al, 2002), inhibition of proliferation of hepatoma cell lines (Kao et al, 2001), modulation of allergic inflammation in a murine model of asthma (Ishimitsu et al, 2001), antiaging effects in mice (Shih et al, 2000) and suppression of IgE production in mice (Kaneko et al, 1997).…”

Dendritic cells as critical players in allergic rhinitis

“…Elevated numbers of DCs (CD209 DC-Sign) were observed in allergic fungal rhinosinusitis (39). Models of AR showed an elevated number of DCs (CD11c-positive cells with a dendritic morphology) (4,40,41). Moreover, the tolerogenic number of DCs as measured as CD11c' ADLH1/2' cells was shown to be reduced in AR mice, and the corresponding number of FoxP3 shows the same reduction, indicating an impaired tolerogenic response in AR mice (41).…”

“…Models of AR showed an elevated number of DCs (CD11c-positive cells with a dendritic morphology) (4,40,41). Moreover, the tolerogenic number of DCs as measured as CD11c' ADLH1/2' cells was shown to be reduced in AR mice, and the corresponding number of FoxP3 shows the same reduction, indicating an impaired tolerogenic response in AR mice (41). A nice example of increased levels of HLADR' CD209' CD14' DCs of other nasal disease pathogens is seen in the circulation of rhinitis patients with or without nasal polyps.…”

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

“…It has been reported that the immunosuppressive components or extracts of CHM could ameliorate autoimmune, allergic or inflammatory diseases Xie et al, 2011;Zhang et al, 2014;. Plumbagin (3 and 5 μM) ameliorated the clinical symptoms of experimental autoimmune encephalomyelitis in mice, including central nervous system inflammation and demyelination through inhibition of the maturation and function of DCs and the expression of Th1-and Th17-polarizing cytokines .…”

“…Bu-Zhong-Yi-Qi-Tang (0.3 ml daily) improved the allergic rhinitis-like symptoms and immune pathology and immune tolerance status in the nasal mucosa of allergic rhinitis mouse model through increasing the frequency of Tregs and Not mentioned Not mentioned Wang et al (2006) tolerogenic DCs (CD11c þ ALDH þ ) (Xie et al, 2011). In a mice model of atherosclerosis, Naoxintong treatment (0.7 g/kg/d) reduced plasma triglyceride, total cholesterol and vascular lesions compared to placebo treatment through reduced the expressions of CD40, CD80 and CD86 in splenic DCs and the plasma level of IL-12 compared to control group (J. .…”