Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists

Tripathi, Trivendra; Shahid, Mohammad; Khan, Haris M.; Negi, Mahendra Pal Singh; Siddiqui, M. B.; Khan, Rahat

doi:10.1016/s1734-1140(10)70352-2

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Both Hrh1and Ythdf1 were upregulated in mammary gland of rats exposed to HF in utero compared with controls. As described above, Hrh1 is involved in regulating omega-6 fatty acids release and immune functions [35,43]. Ythdf1 modulates RNA degradation in a N6-methyladenosine (m 6 A) dependent manner [44].…”

Section: Discussionmentioning

confidence: 99%

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Andrade

Assis

Jin

et al. 2015

Chemico-Biological Interactions

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The persistent effects of animal fat consumption during pregnancy and nursing on the programming of breast cancer risk among female offspring were studied here. We have previously found that female offspring of rat dams that consumed a lard-based high-fat (HF) diet (60% fat-derived energy) during pregnancy, or during pregnancy and lactation, were at a reduced risk of developing mammary cancer. To better understand the unexpected protective effects of early life lard exposure, we have applied lipidomics and nutrigenomics approaches to investigate the fatty acid profile and global gene expression patterns in the mammary tissue of the female offspring. Consumption of this HF diet during gestation had few effects on the mammary tissue fatty acids profile of young adult offspring, while exposure from gestation throughout nursing promoted significant alterations in the fatty acids profile. Major differences were related to decreases in saturated fatty acids (SFA) and increases in omega-6 polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and conjugated linolenic acid (CLA) concentrations. In addition several differences in gene expression patterns by microarray analysis between the control and in utero or in utero and during lactation HF exposed offspring were identified. Differential dependency network (DDN) analysis indicated that many of the genes exhibited unique connections to other genes only in the HF offspring. These unique connections included Hrh1-Ythdf1 and Repin1-Elavl2 in the in utero HF offspring, and Rnf213-Htr3b and Klf5-Chrna4 in the in utero and lactation HF offspring, compared with the control offspring. We conclude that an exposure to a lard-based HF diet during early life changes the fatty acid profile and transcriptional network in mammary gland in young adult rats, and these changes appear to be consistent with reduced mammary cancer risk observed in our previous study.

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Section: Discussionmentioning

confidence: 99%

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Andrade

Assis

Jin

et al. 2015

Chemico-Biological Interactions

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“…While, in vivo effects of histamine, pheniramine (H1R-antagonist), histamine trifl uoro-methyl toluidide (H1R-agonist), ranitidine (H2Rantagonist) and amthamine (H2R-agonist) in immunized animals demonstrated impaired hepatic functions (12)(13)(14). These fi ndings, along with our previous studies of HR agonists and antagonists (7)(8)(9)(10) demonstrate that though HR agonists and antagonists are mildly hepatotoxic yet these might be useful for immune targeted diseases. Therefore, we have designed hepatic studies to explore the degree of hepatotoxicity of each histamine receptor's agonist and antagonist that were used in our previous immunotoxic studies.…”

mentioning

confidence: 65%

“…Although the physiological and pathological relevance of histamine receptors (HR) and their distribution in various tissues are being documented (2), the exact role of various HR agonists and antagonists on liver functions are still unknown. Our previous studies have shown immunomodulatory and hepatotoxic roles of HR agonists and antagonists (7)(8)(9)(10)(11). While, in vivo effects of histamine, pheniramine (H1R-antagonist), histamine trifl uoro-methyl toluidide (H1R-agonist), ranitidine (H2Rantagonist) and amthamine (H2R-agonist) in immunized animals demonstrated impaired hepatic functions (12)(13)(14).…”

mentioning

confidence: 99%

Biochemical alteration of hepatic functions by histamine H3-receptor agonist and antagonist in immunized rabbits

Tripathi¹,

Khan²,

Shahid³

et al. 2013

BLL

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Aim: The aim of our study was to investigate the functional roles of H3R agonist and antagonist in the development of hepatic functions impairment in immunized rabbits. Methods: The study comprised of six groups containing 18 rabbits in each. Group-I (negative control) and group-II (positive control) received sterile distilled water intramuscularly while Group III-VI received histamine (100 μgkg-1 , s.c.), R-[-]-α-methylhistamine (H3R-agonist, 10 μgkg-1 , s.c.), iodophenpropit (H3R-antagonist, 1 μgkg-1 , i.m.), and the combination of iodophenpropit (1 μgkg-1 , i.m.) plus histamine (100 μgkg-1 , s.c.), respectively, b.i.d. (12 hours [8 am and 8 pm]) for 10 days. Groups II-VI were immunized on day 3 with intravenous injection of sheep red blood cells (1×10 9 cells/ml). Results: On each experimental day, the mean values of serum enzymes and bilirubin in group-I and group-II showed no changes while in groups III, IV, V, and VI, these enzymes and bilirubin levels showed signifi cant changes (p<0.05), when compared with their values within the group. Profi le of ALT and AST production revealed that ALT and AST levels moderately were changed due to degeneration of the liver. Conclusion: Our results suggest that R-[-]-α-methylhistamine showed moderate, and histamine and iodophenpropit showed mild degeneration of liver functions; while iodophenpropit plus histamine showed hepatic functions similar to control group. This study suggests that H3R antagonist in combination with histamine may be a non-toxic therapeutic target for histamine research (Fig. 7, Ref. 28). Text in PDF www.elis.sk.

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“…Blood samples were kept at room temperature for 2 hr and then at 4 ºC overnight. Blood samples were centrifuged for 10 minutes at 580×g, and serum was isolated and heated at 56 ºC for 30 minutes to inactivate complement proteins and stored in aliquots containing sodium azide as preservative at -20 ºC (4,5,8,10,14,15) till tested further.…”

Section: Sample Collectionmentioning

confidence: 99%

“…Immunomodulation studies in rabbit model have showed that histamine has a short-term effect on antibody generation and the antibody (Immunoglobulins (Ig), immunoglobulin-M (IgM), and IgG) production in vivo were affected by the concentration of histamine (4,5). Histamine receptors (H1R and H2R) have been shown to enhance delayed hypersensitivity and antibody mediated immune responses in many pathological processes regulating several essential events in allergies and autoimmune diseases in experimental animals, especially in knock out mice (either H1R-or H2R-defi cient) (6)(7)(8). Histamine and HRs (H1R and H2R)-agonist enhances antibody production by triggering the histamine receptors (H1R and H2R), whereas both H1R-antagonist and H2R-antagonist positively or negatively regulate the antibody profi le.…”

mentioning

confidence: 99%

In vivo study of histamine H4 receptor in immunomodulation

Tripathi¹,

Shahid²,

Khan³

et al. 2012

BLL

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Abstract:Objective: Recently accumulating evidence has highlighted the role of histamine in infl ammation and immune reaction by histamine H4-receptor, however the role of histamine via H4-receptor in immunomodulation is still unclear. Therefore, the present study was designed to study the immunomodulatory role of histamine H4-receptor on antibody generation profi le in rabbit. Results: Histamine could infl uence a detectable antibody response to SRBC as early as day 7 postimmunization (post-I), which lasted until day 58 post-I, whereas H4-receptor by H4R-antagonist treatment showed a similar profi le of antibody (Ig, IgM, and IgG) generation as the positive control group. On the other hand, H4R-agonist treatment showed immunostimulant activity as compared to other experimental groups. The results were found statistically signifi cant (p<0.01). Conclusions: Histamine H4-receptor in biological system modulates immunological function and stimulates antibody production only by exogenously administered agonists not by endogenous histamine (Tab. 1, Fig. 3, Ref. 26). Full Text in PDF www.elis.sk.

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Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists

Cited by 10 publications

References 13 publications

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Biochemical alteration of hepatic functions by histamine H3-receptor agonist and antagonist in immunized rabbits

In vivo study of histamine H4 receptor in immunomodulation

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