Modulation of leucocyte activation in the early phase of the rabbit burn injury

Lavaud, Philippe; Mathieu, Jacques; Bienvenu, P; Braquet, M.; Gerasimo, P.; Kergonou, Jean-François; Ducousso, R.

doi:10.1016/s0305-4179(98)90035-3

Cited by 15 publications

(5 citation statements)

References 20 publications

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“…The function of NK cells is diminished following significant injury (362). Neutrophil dysfunction after significant thermal injuries has also been reported (44,137,175,242). Endothelial adherence of neutrophils is initially decreased after injury and then increases (374); however, the site of endothelial adhesion may not be at the point of injury, and this misguided neutrophil adhesion and activation contribute to neutrophil-mediated endothelial injury, which may play a significant role in the pathogenesis VOL.…”

Section: Innate Immune System Response To Burn Injurymentioning

confidence: 98%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,622

1,345

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SUMMARYBurns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal injuries induce a state of immunosuppression that predisposes burn patients to infectious complications. A current summary of the classifications of burn wound infections, including their diagnosis, treatment, and prevention, is given. Early excision of the eschar has substantially decreased the incidence of invasive burn wound infection and secondary sepsis, but most deaths in severely burn-injured patients are still due to burn wound sepsis or complications due to inhalation injury. Burn patients are also at risk for developing sepsis secondary to pneumonia, catheter-related infections, and suppurative thrombophlebitis. The introduction of silver-impregnated devices (e.g., central lines and Foley urinary catheters) may reduce the incidence of nosocomial infections due to prolonged placement of these devices. Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices.

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Section: Innate Immune System Response To Burn Injurymentioning

confidence: 98%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,622

1,345

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“…In burn cases, in ammatory response is associated with local and systematic tissue damage and lipid peroxidation [2,3], as re ected by an increase in macrophage activity and production of pro-in ammatory mediators and evenincreased levels of interleukin 1 beta (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), tumor growth factor beta (TGF-β), leukotriene B4 (LTB4) and lipoxygenase metabolites [4][5][6]. is suggests that pro-in ammatory cascade plays a role in a number of post-burn complications [7].…”

mentioning

confidence: 99%

Effects of montelukast on burn wound healing in a rat model

Turtay

Fırat²,

Şamdancı³

et al. 2010

CIM

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Purpose: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the effects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. Methods: Rats were randomly allocated to four groups after local burn development: Group 1; rats were left to secondary healing without treatment, Group 2; a dose of 10 mg/kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10th day was significantly greater, in comparison with control and montelukast groups (p < 0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 20th day) were statistically improved in comparison with the control group (p < 0.05). For the montelukast+pomade group, angiogenesis, fibroblast proliferation and macrophage infiltration (on the 10th day), and angiogenesis, fibroblast proliferation, edema and macrophage infiltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p < 0.05). Conclusion: In conclusion, montelukast was effective on burn wound healing. Moreover, the effect was amplified when combined with topical antibiotics applied in the early stage of burn wound healing.

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“…• Blood immune cell count ( 14) (Bjornson et al 1988;Chao et al 2020;D'Alesandro and Gruber 1990;Fujimi et al 2006;Heideman 1979;Khalid et al 2019;Kuroiwa et al 1990;Lavaud et al 1988;Linz et al 2017;Malakyan et al 2004;Newsome and Eurenius 1973;Noel et al 2010;Pallua et al 2003;Schindel et al 1997;Wallner et al 1987) J o u r n a l P r e -p r o o f 3…”

Section: Monocytesunclassified

“…J o u r n a l P r e -p r o o f 2020; D'Alesandro and Gruber 1990;Fuchs et al 2006;Goertz et al 2016;Goertz et al 2012;Goertz et al 2011b;Goertz et al 2011a;Goertz et al 2009;Gómez et al 2020;Gómez et al 2018;Groger et al 2010;Heideman 1979;Hummel et al 1966;Inoue et al 2018;Iwashita et al 1999;Jabeen et al 2019;Jurjus et al 2007;Kimura et al 2008;Langer et al 2005;Lavaud et al 1988;Mikhal'chik et al 2004;Nassar et al 2012;Nwariaku et al 1995;Ny et al 2020;Piccolo et al 1999;Rawlingson et al 2003;Rawlingson et al 2001;Santos et al 2000;Schwacha et al 2019;Tian et al 2016;Till et al 1983;Yao et al 1997; Zhuravleva et al…”

Section: Subgroup Analysisunclassified