Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat

Pulvirenti, Luigi; Berrier, Renate; Kreifeldt, Max; Koob, George

doi:10.1016/0006-8993(94)91977-1

Cited by 104 publications

(52 citation statements)

References 26 publications

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“…One caveat in the present neurochemical analysis must be considered: a distinction between core and shell subregions of the nucleus accumbens is not reported. Dopaminergic activity in the core of the nucleus accumbens is closely aligned with motor activity and instrumental learning Kelley and Swanson, 1997;MaldonadoIrizarry and Kelley, 1994;Pulvirenti et al, 1994), whereas dopamine in the shell appears responsive to primary rewards (Carlezon and Wise, 1996;Di Chiara et al, 1993;Tanda et al, 1997). Based on our behavioral results, the core but not shell is predicted to show age-related differences in extracellular dopamine after i.p.…”

Section: Discussionmentioning

confidence: 56%

Behavioral and Neurochemical Responses to Cocaine in Periadolescent and Adult Rats

Frantz

O’Dell

Parsons

2006

Neuropsychopharmacol

120

139

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Although recreational drug use by human adolescents is a well-known and long-standing problem, relatively little is known regarding differences in behavioral and physiological responses to abused substances in adolescent vs adult animals. The present study compared effects of the psychomotor stimulant, cocaine, in periadolescent (postnatal days 37-52) and adult (postnatal days 75-90) male Wistar rats. Locomotion and motor stereotypy were recorded after acute and repeated cocaine injections (0, 10, or 20 mg/kg cocaine, intraperitoneal (i.p.), four injections spaced 5 days apart). Spontaneous acquisition of intravenous (i.v.) cocaine self-administration was investigated in two dose groups (B0.37 or 0.74 mg/kg/infusion) over 14 days. Dopamine levels in the nucleus accumbens were recorded under basal conditions (no net flux method) and after cocaine administration (B0.37, 0.74, and 2.92 mg/kg/i.v. infusion or 20 mg/kg i.p.) using in vivo microdialysis. The locomotor data are in partial agreement with previous reports of hyposensitivity to acute cocaine in periadolescent vs adult rats; periadolescents were less active overall than adults. Moreover, adult rats exhibited significant locomotor sensitization after repeated injection of 10 mg/kg cocaine, whereas periadolescents required the high dose of 20 mg/kg cocaine to demonstrate sensitization. Neither age group showed sensitization of motor stereotypies. No age-related difference was observed in acquisition of cocaine self-administration, or in basal or cocaine-stimulated nucleus accumbens dopamine. These experiments imply a developmental dissociation between the motor activating and reinforcing effects of cocaine. Similarities in dopamine levels across age groups suggest that age-specific motor responses to cocaine are not mediated by dopamine in the nucleus accumbens. Neuropsychopharmacology (2007) 32, 625-637.

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Section: Discussionmentioning

confidence: 56%

Behavioral and Neurochemical Responses to Cocaine in Periadolescent and Adult Rats

Frantz

O’Dell

Parsons

2006

Neuropsychopharmacol

120

139

View full text Add to dashboard Cite

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“…The transient nature of this effect may reflect the short time course of action of AP-5. Indeed, when doses similar to the lower ones used in the present study were infused generally into the NAcc (Burns et al 1994), or into the shell (Pulvirenti et al 1994), increases in spontaneous motor activity lasted for only 20 or 30 minutes, which is the time needed to complete the first two ratio requirements in the second-order schedule used here.…”

Section: The Effects Of Nmda Receptor Antagonism In the Core And Shellmentioning

confidence: 77%

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

Ciano

Everitt

2001

Neuropsychopharmacology

258

191

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“…The dopaminergic system in the ACC plays an important role in control of spontaneous, psychostimulants (2)-and MK-801 (3 -6)-induced locomotor hyperactivity. On the other hand, the allocortical-originated glutamatergic afferents could modulate the psychomotor activation and drug reinforcement (7). Moreover, the glutamatergic and dopaminergic systems not only separately alter the behavioral effects but could also act by interacting and modulating the function of each other.…”

mentioning

confidence: 99%

Role of Dopaminergic System in Core Part of Nucleus Accumbens in Hyperlocomotion and Rearing Induced by MK-801 in Rats: A Behavioral and In Vivo Microdialysis Study

Hatip‐Al‐Khatib

Bolukbasi

Mishima

et al. 2001

Japanese Journal of Pharmacology

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ABSTRACT-We investigated modification of the MK-801 effect on motor activity and extracellular amines concentration by 6-hydroxydopamine (6-OHDA)-induced lesion of core nucleus accumbens (cACC) of rats. In vivo microdialysis-HPLC showed that the concentrations (fmol /ml) of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and serotonin were 0.738 ± 0.135, 155.34 ± 41.01 and 0.334 ± 0.024, respectively, in the cACC of intact rats. The DOPAC /DA ratio was 264.24 ± 94.01. Unilateral lesion of the cACC with 6-OHDA (8 mg/ml) substantially reduced DA (-93%) and DOPAC (-97%) in desipramine (30 mg /kg, i.p.)-pretreated rats (6-OHDA+DMI rats) as compared to the 65% reduction rate of both amines in salinepretreated rats (6-OHDA+saline rats). Moreover, DOPAC was reduced by 72% in 6-OHDA+DMI rats. MK-801 increased DOPAC (426 -467%) and DOPAC /DA ratio (180 -230%) in intact rats. On the other hand, MK-801 increased DA by 154% and 505% in 6-OHDA+saline and 6-OHDA+DMI rats, respectively. 6-OHDA reduced the effect of MK-801 on DOPAC and DOPAC /DA ratio. In the behavioral studies, MK-801 (0.01 -0.3 mg /kg, i.p.) increased locomotor activity and rearing of intact rats. Bilateral 6-OHDA+DMI lesion of the cACC caused greater reduction in the effect of MK-801 (0.1 mg /kg) than that of the shell nucleus accumbens. These results suggest that increased extracellular DOPAC concentration (but not DA) and DOPAC /DA ratio in the cACC plays an important role in MK-801-hyperactivity.Keywords: MK-801, Core nucleus accumbens (rat), Microdialysis, Motor activityThe nucleus accumbens (ACC) is a part of the mesocortical and mesolimbic dopaminergic system. The ACC receives dopaminergic inputs from the ventral tegmental area (VTA) and glutamatergic inputs that originate from cortical regions (including medial frontal), amygdala and midline thalamus (1). The ACC is involved in a variety of behavioral activities. The dopaminergic system in the ACC plays an important role in control of spontaneous, psychostimulants (2)-and MK-801 (3 -6)-induced locomotor hyperactivity. On the other hand, the allocortical-originated glutamatergic afferents could modulate the psychomotor activation and drug reinforcement (7). Moreover, the glutamatergic and dopaminergic systems not only separately alter the behavioral effects but could also act by interacting and modulating the function of each other. A functional interaction has been reported between the glutamatergic system (via Nmethyl-D-aspartate (NMDA) receptors) and the dopaminergic system at the striatal levels (8) with a negative modulatory effect of the glutamatergic system on the dopaminergic one (9). The consequence of glutamate block depends on which of glutamate receptors are blocked. In the ACC, it is suggested that antagonists that block only NMDA autoreceptors increase synaptic glutamate level and disinhibit dopaminergic terminals. On the other hand, NMDA and non-NMDA antagonists that block both the glutamate autoreceptors and postsynaptic receptors inactivate the dopaminergic terminals (10).Cytoarchite...

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Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat

Cited by 104 publications

References 26 publications

Behavioral and Neurochemical Responses to Cocaine in Periadolescent and Adult Rats

Behavioral and Neurochemical Responses to Cocaine in Periadolescent and Adult Rats

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

Role of Dopaminergic System in Core Part of Nucleus Accumbens in Hyperlocomotion and Rearing Induced by MK-801 in Rats: A Behavioral and In Vivo Microdialysis Study

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