Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine

Gold, Paul E.; Delanoy, Richard L.; Merrin, James

doi:10.1016/0006-8993(84)91124-7

Cited by 89 publications

(41 citation statements)

References 23 publications

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“…Studies also showed that amphetamine and methamphetamine produced significant CPP (Carr et al 1988;Bardo et al 1999;Parker et al 2004;Thorn et al 2012, Han et al 2014) and self-administration (Lyness et al 1979;Piazza et al 1989Piazza et al , 1990Piazza et al , 1991Krasnova et al 2010;McClung et al 2010), which suggests that the rewarding effects of amphetamine and methamphetamine facilitated the formation of drug-context associations. In line with acute amphetamine's enhancing effects on hippocampus-dependent learning and memory, hippocampal LTP was also increased by acute amphetamine (Delanoy et al 1983;Gold et al 1984;Morimoto et al 1987) and methamphetamine administration (Heysieattalab et al 2016). Moreover, evidence suggests that acute methamphetamine-induced enhancement of hippocampus-dependent learning as well as amphetamine CPP are dependent on the upregulation of ERK1/-2 and CREB in the hippocampus (Gerdjikov et al 2004;Cao et al 2013).…”

Section: Amphetaminementioning

confidence: 67%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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It has long been hypothesized that conditioning mechanisms play major roles in addiction. Specifically, the associations between rewarding properties of drugs of abuse and the drug context can contribute to future use and facilitate the transition from initial drug use into drug dependency. On the other hand, the self-medication hypothesis of drug abuse suggests that negative consequences of drug withdrawal result in relapse to drug use as an attempt to alleviate the negative symptoms. In this review, we explored these hypotheses and the involvement of the hippocampus in the development and maintenance of addiction to widely abused drugs such as cocaine, amphetamine, nicotine, alcohol, opiates, and cannabis. Studies suggest that initial exposure to stimulants (i.e., cocaine, nicotine, and amphetamine) and alcohol may enhance hippocampal function and, therefore, the formation of augmented drug-context associations that contribute to the development of addiction. In line with the self-medication hypothesis, withdrawal from stimulants, ethanol, and cannabis results in hippocampus-dependent learning and memory deficits, which suggest that an attempt to alleviate these deficits may contribute to relapse to drug use and maintenance of addiction. Interestingly, opiate withdrawal leads to enhancement of hippocampus-dependent learning and memory. Given that a conditioned aversion to drug context develops during opiate withdrawal, the cognitive enhancement in this case may result in the formation of an augmented association between withdrawalinduced aversion and withdrawal context. Therefore, individuals with opiate addiction may return to opiate use to avoid aversive symptoms triggered by the withdrawal context. Overall, the systematic examination of the role of the hippocampus in drug addiction may help to formulate a better understanding of addiction and underlying neural substrates.Addiction is a major worldwide health problem that results in maladaptive behavioral changes, some that can last a lifetime. This behavioral plasticity, often times maladaptive, must be associated changes in neural plasticity. In fact, it has been noted multiple times that there is a high degree of overlap between the neurobiology of learning and memory and the neurobiology of addiction

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Section: Amphetaminementioning

confidence: 67%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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“…As activation of DA receptors can modulate the expression of glutamate receptors, DA receptor activity can, in turn, alter synaptic plasticity (Sun et al 2005). LTP in the dentate gyrus was also found to be enhanced by amphetamine, in a dose-dependent manner (Gold et al 1984). Increased potentiation of population spike amplitude was found in rats that had been administered 0.01, 0.1, 1.0, or 3.0 mg/kg amphetamine, i.p., while doses higher (10.0 mg/kg) and lower (0.001 mg/kg) produced no differences, compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Wood

Anagnostaras

2008

Psychopharmacology

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Rationale and Objectives-With prescriptions of stimulants on the rise, it is important to examine the cognitive effects of low and moderate doses of stimulants, rather than only those typical of addicts.Methods-The present study examined the effects a range of doses (0.005 -8 mg/kg) of damphetamine sulfate on cued and contextual Pavlovian fear conditioning in mice.Results-In agreement with previous research, subjects administered a moderately high dose of amphetamine (8 mg/kg) pre-training, typical of what addicts might take, displayed impaired memory when tested, off-drug. Alternately, subjects injected with a very low dose of amphetamine (0.005, 0.025, or 0.05 mg/kg), pre-training, similar to the therapeutic doses for attention deficit hyperactivity disorder, displayed enhanced memory when tested, off-drug. A control study showed these effects were not due to state-dependent learning.Conclusions-Thus, dose is a critical determinant of the cognitive effects of psychostimulants.

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“…For example, both corticosterone [44] and epinephrine [45] modulate hippocampal LTP in an inverted-U shaped dose-dependent function. The former can enter the brain and act on corticosteroid receptors [46] while the latter may have central effects on hippocampal function through its hyperglycemic actions [7].…”

Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats

Zuo

Smith

Jensen

2007

Physiology & Behavior

112

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Vagus nerve stimulation potentiates hippocampal LTP in freely moving rats. --Previous studies have demonstrated that electrical stimulation of the vagus nerve (VNS) delivered at a moderate intensity following a learning experience enhances memory in laboratory rats and human subjects, while VNS at lower or higher intensities has little or no effect. This finding suggests that VNS may affect memory processes by modulating neural plasticity in brain structures associated with memory storage such as the hippocampus. To test this hypothesis, the present study investigated the modulatory effect of VNS on the development of long-term potentiation (LTP) in the dentate gyrus of freely-moving rats. Rats receiving 0.4 mA VNS showed enhanced potentiation of the population spike amplitude for at least 24 hr after tetanus relative to the sham-stimulation group. In contrast, no such effect was observed with 0.2 mA VNS. Stimulation at 0.8 mA had a short-term effect and tended to enhance early LTP, but to a lesser extent than did 0.4 mA. The 0.4 mA stimulation was the same intensity that was previously shown to enhance retention performance in an inhibitory avoidance task. These findings suggest that the neural mechanisms underlying the mnemonic effect of VNS may involve modulating synaptic plasticity in the hippocampus. These data also suggest that neural activity in the vagus nerve, occurring as a result of changes in peripheral state, is an important mechanism by which emotional experiences and arousal can enhance the storage of memories of those experiences.

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Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine

Cited by 89 publications

References 23 publications

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Vagus nerve stimulation potentiates hippocampal LTP in freely-moving rats

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