2012
DOI: 10.1152/jn.00319.2011
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Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation

Abstract: Transcranial direct current stimulation (tDCS) can produce a lasting polarity-specific modulation of cortical excitability in the brain, and it is increasingly used in experimental and clinical settings. Recent studies suggest that the after-effects of tDCS are related to molecular mechanisms of activity-dependent synaptic plasticity. Here we investigated the effect of DCS on the induction of one of the most studied N-methyl-d-aspartate receptor-dependent forms of long-term potentiation (LTP) of synaptic activ… Show more

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Cited by 192 publications
(154 citation statements)
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“…Asymmetries have been found in other animal studies [10], [13] and human studies [1], [50]. In parallel work in our lab, we find an asymmetry in acute DCS effects on cellular excitability.…”
Section: Effect Asymmetrysupporting
confidence: 88%
“…Asymmetries have been found in other animal studies [10], [13] and human studies [1], [50]. In parallel work in our lab, we find an asymmetry in acute DCS effects on cellular excitability.…”
Section: Effect Asymmetrysupporting
confidence: 88%
“…A shift to the right by cathodal stimulation abolished PAS LTP -induced LTP-like plasticity, while a shift to the left by anodal stimulation enhanced it (Nitsche et al, 2007). Similarly, cathodal vs anodal stimulation of rat hippocampal slices respectively suppressed or enhanced subsequent LTP induction (Ranieri et al, 2012).…”
Section: Drug Effects On Pas Ltp -Induced Ltp-like Increase Of Mep Iomentioning
confidence: 90%
“…Delayed tDCS-response has been observed in previous studies assessing the effect of tDCS on pain and MEP in patients with migraine and elderly people, respectively [48,49]. tDCS mechanisms are related to its influence on sodium and calcium channels opening and NMDA receptors excitability [50], while longlasting effects are analogous to activity-dependent synaptic plasticity, namely long-term potentiation (LTP) and long-term depression (LTD) [51][52][53]. Structural, functional and connectivity alterations at the cortical level have been described in patients with SCI, especially in the somatosensory cortex, consequently to the injury itself, as well as a result of the lack of sensory and motor inputs [54][55][56]; these changes being related to neuropathic pain [57].…”
Section: Delayed Tdcs Effects On Pain Reductionmentioning
confidence: 98%