Modulation of macrophage phagocytosis in vitro —A role for cholinergic stimulation?

Moussa, Amira-Talaat; Rabung, Andrea; Reichrath, Sandra; Wagenpfeil, Stefan; Dinh, Thai; Krasteva‐Christ, Gabriela; Meier, Carola; Tschernig, Thomas

doi:10.1016/j.aanat.2017.07.007

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The muscarinic agonist, carbachol, causes a moderate enhancement in phagocytosis of zymosan particles by primary peritoneal macrophages (301). Depending on the local microenvironment, several mAChR subtypes were reported on differentiated resident macrophages.…”

Section: Role In Macrophagesmentioning

confidence: 99%

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

2021

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Neurological and immunological signals constitute an extensive regulatory network in our body that maintains physiology and homeostasis. The cholinergic system plays a significant role in neuroimmune communication, transmitting information regarding the peripheral immune status to the central nervous system (CNS) and vice versa. The cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ACh), cholinergic receptors (AChRs), choline acetyltransferase (ChAT) enzyme, and acetylcholinesterase (AChE) enzyme. These molecules are involved in regulating immune response and playing a crucial role in maintaining homeostasis. Most innate and adaptive immune cells respond to neuronal inputs by releasing or expressing these molecules on their surfaces. Dysregulation of this neuroimmune communication may lead to several inflammatory and autoimmune diseases. Several agonists, antagonists, and inhibitors have been developed to target the cholinergic system to control inflammation in different tissues. This review discusses how various molecules of the neuronal and non-neuronal cholinergic system (NNCS) interact with the immune cells. What are the agonists and antagonists that alter the cholinergic system, and how are these molecules modulate inflammation and immunity. Understanding the various functions of pharmacological molecules could help in designing better strategies to control inflammation and autoimmunity.

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Section: Role In Macrophagesmentioning

confidence: 99%

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

2021

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“…O agonista muscarínico, carbacol, causa um aumento moderado na fagocitose de partículas de zimosan por macrófagos peritoneais primários [205]. Dependendo do microambiente local, vários subtipos de mAChR foram relatados em macrófagos residentes diferenciados.…”

Section: 6acetilcolinaunclassified

O desbalanço de CD36 e CD14 está correlacionado com os níveis de acetilcolina, de mediadores lipídicos e com a gravidade em pacientes infectados com SARS-CoV-2

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Intercellular communication between alveolar epithelial cells and macrophages

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Grißmer

Meier

et al. 2020

Annals of Anatomy - Anatomischer Anzeiger

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Modulation of macrophage phagocytosis in vitro —A role for cholinergic stimulation?

Cited by 4 publications

References 33 publications

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

O desbalanço de CD36 e CD14 está correlacionado com os níveis de acetilcolina, de mediadores lipídicos e com a gravidade em pacientes infectados com SARS-CoV-2

Intercellular communication between alveolar epithelial cells and macrophages

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