2022
DOI: 10.1007/s12015-022-10452-7
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Modulation of Mesenchymal Stem Cells-Mediated Adaptive Immune Effectors’ Repertoire in the Recovery of Systemic Lupus Erythematosus

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Cited by 4 publications
(4 citation statements)
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“…Hence, targeting MSCs and manipulating them may offer significant clinical benefits in the treatment outcome of SLE. Previous studies have shown improvements after allogenic MSC-based therapy in both mouse models of SLE and patients (reviewed in [ 3 , 14 ]). MSCs are the focus of extensive investigation as a natural biotreatment due to their unique features, including lack of immune activity, inherent ability to fight inflammation, and promote immunological tolerance [ 64 , 72 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Hence, targeting MSCs and manipulating them may offer significant clinical benefits in the treatment outcome of SLE. Previous studies have shown improvements after allogenic MSC-based therapy in both mouse models of SLE and patients (reviewed in [ 3 , 14 ]). MSCs are the focus of extensive investigation as a natural biotreatment due to their unique features, including lack of immune activity, inherent ability to fight inflammation, and promote immunological tolerance [ 64 , 72 ].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, there was no significant difference regarding the infiltration of cells between N-MSCs, R-MSCs, and DR-MSCs treatment groups; however, potent reduction in the D-MSCs group, illustrating that immunomodulation by R-MSCs in advance has a much higher beneficial effect in reducing inflammation. Several studies have shown that MSCs can induce tolerance by direct effects and via mobilization of suppressor cell populations (reviewed in [ 14 ]). In explaining the higher population of infiltrating cells in mice treated with rhamnosus-pretreated MSC than D-MSCs, it can be suggested that R-MSCs may promote the mobilization of immune regulatory cells to the kidney, after that, they act in ameliorating tissue damage [ 90 ].…”
Section: Discussionmentioning
confidence: 99%
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“…These promising results suggest the possibility of a safer and more‐convenient combined biologic‐ and cell‐based therapy. Due to their anti‐inflammatory and immunomodulatory capabilities, several studies have reported the use of MSCs as a therapeutic strategy for treating autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, type I diabetes, and systemic lupus erythematosus (Hoseinzadeh et al, 2023; Liu et al, 2020; Xun et al, 2022; Zhang et al, 2022).…”
Section: Experimental Approaches Using Cell‐based Therapies For Sg Hy...mentioning
confidence: 99%