Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila

Su, Chih‐Ying; Wang, Jing W.

doi:10.1016/j.conb.2014.04.008

Cited by 40 publications

(32 citation statements)

References 60 publications

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“…Hunger, in turn, promotes the stimulation of food intake [3, 4] and selection of nutritious foods [5]. It also produces enhanced sensory sensitivities and elevated locomotion in insects [6, 7] and mammals [8, 9]. Despite the fact that this process is basic to existence among all types of animals, the mechanism(s) by which hunger triggers feeding and hunger-driven behaviors is not well understood in any animal system.…”

Section: Introductionmentioning

confidence: 99%

Drosophila SLC5A11 Mediates Hunger by Regulating K + Channel Activity

et al. 2016

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SUMMARY Hunger is a powerful drive that stimulates food intake. Yet the mechanism that determines how the energy deficits that result in hunger are represented in the brain and promote feeding is not well understood. We previously described SLC5A11 – a sodium/solute co-transporter-like – (or cupcake) in Drosophila melanogaster, which is required for the fly to select a nutritive sugar over a sweeter nonnutritive sweetener after periods of food deprivation. SLC5A11 acts on approximately 12 pairs of ellipsoid body (EB) R4 neurons to trigger the selection of nutritive sugars, but the underlying mechanism is not understood. Here, we report that the excitability of SLC5A11-expressing EB R4 neurons increases dramatically during starvation and that this increase is abolished in the SLC5A11 mutation. Artificial activation of SLC5A11-expresssing neurons is sufficient to promote feeding and hunger-driven behaviors; silencing these neurons has the opposite effect. Notably, SLC5A11 transcript levels in the brain rose significantly when flies were starved, and dropped shortly after starved flies were refed. Furthermore, expression of SLC5A11 is sufficient for promoting hunger-driven behaviors and enhancing the excitability of SLC5A11-expressing neurons. SLC5A11 inhibits the function of Drosophila KCNQ potassium channel in a heterologous expression system. Accordingly, a knock-down of dKCNQ expression in SLC5A11-expressing neurons produces hunger-driven behaviors even in fed flies, mimicking the overexpression of SLC5A11. We propose that starvation increases SLC5A11 expression, which enhances the excitability of SLC5A11-expressing neurons by suppressing dKCNQ channels, thereby conferring the hunger state.

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Section: Introductionmentioning

confidence: 99%

Drosophila SLC5A11 Mediates Hunger by Regulating K + Channel Activity

et al. 2016

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“…Many neuroendocrine and neuromodulatory pathways also influence satiety and feeding in Drosophila, and have been recently reviewed (Itskov and Ribeiro 2013, Su and Wang 2014. One example is that a method called TANGO (which detects the site of action of endogenous neuromodulators) showed that starvation causes dopamine release in the SEZ, where DopEcR dopamine receptors modulate the gain of sweet receptor terminals (Inagaki et al 2012).…”

Section: Influences Of Hunger and Satietymentioning

confidence: 99%

Motor control of fly feeding

McKellar¹

2016

Journal of Neurogenetics

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Following considerable progress on the molecular and cellular basis of taste perception in fly sensory neurons, the time is now ripe to explore how taste information, integrated with hunger and satiety, undergo a sensorimotor transformation to lead to the motor actions of feeding behavior. I examine what is known of feeding circuitry in adult flies from more than 250 years of work in larger flies and from newer work in Drosophila. I review the anatomy of the proboscis, its muscles and their functions (where known), its motor neurons, interneurons known to receive taste inputs, interneurons that diverge from taste circuitry to provide information to other circuits, interneurons from other circuits that converge on feeding circuits, proprioceptors that influence the motor control of feeding, and sites of integration of hunger and satiety on feeding circuits. In spite of the several neuron types now known, a connected pathway from taste inputs to feeding motor outputs has yet to be found. We are on the threshold of an era where these individual components will be assembled into circuits, revealing how nervous system architecture leads to the control of behavior.

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“…CO 2 , generally repellent to the fly [44], is also a byproduct of fermenting fruit, a strong natural attractant and food source for the fly. A good deal of evidence describes how the olfactory periphery can accommodate the integration of these opposing signals [3] but higher order neural circuits also play a role [15,43**]. Overlapping with the same region of the mushroom body as the CO 2 -responsive glutamatergic MBONs [43**], are a subset of vinegar odor-responsive mushroom body-projecting dopamine-positive PAM neurons that when activated support attraction behavior.…”

Section: Hedonic and Food Cue Processing Along The Mushroom Body Pathwaymentioning

confidence: 99%

“…Prior to initiating feeding, neural systems must integrate food cue information from the external environment with information about internal satiety state to initiate motor programs that drive the search for food [1–3]. Odors are among the primary cues guiding such foraging behavior.…”

Section: Introductionmentioning

confidence: 99%

The good, the bad, and the hungry: how the central brain codes odor valence to facilitate food approach in Drosophila

Sachse

Beshel

2016

Current Opinion in Neurobiology

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All animals must eat in order to survive but first they must successfully locate and appraise food resources in a manner consonant with their needs. To accomplish this, external sensory information, in particular olfactory food cues, need to be detected and appropriately categorized. Recent advances in Drosophila point to the existence of parallel processing circuits within the central brain that encode odor valence, supporting approach and avoidance behaviors. Strikingly, many elements within these neural systems are subject to modification as a function of the fly’s satiety state. In this review we describe those advances and their potential impact on the decision to feed.

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Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila

Cited by 40 publications

References 60 publications

Drosophila SLC5A11 Mediates Hunger by Regulating K + Channel Activity

Drosophila SLC5A11 Mediates Hunger by Regulating K + Channel Activity

Motor control of fly feeding

The good, the bad, and the hungry: how the central brain codes odor valence to facilitate food approach in Drosophila

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