Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats

Kotlińska, Jolanta; Gibuła-Bruzda, Ewa; Kołtunowska, Dorota; Raoof, Hana; Suder, Piotr; Silberring, Jerzy

doi:10.1016/j.peptides.2011.12.002

Cited by 31 publications

(27 citation statements)

References 87 publications

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“…NPFFR1 mRNA is present in the bed nucleus of the stria terminalis and several amygdaloid nuclei , which are heavily implicated in the regulation of anxiety . Importantly, blockade of the NPFFR subtypes has been shown to attenuate anxiety‐like behaviour in rats undergoing amphetamine and ethanol withdrawal, which are both known to be stressful and anxiogenic conditions . Consistent with these findings, we have recently reported that RFRP‐3 and GJ14 induce anxiogenic‐ and anxiolytic‐like behaviour, respectively, in mice following a 5‐day central infusion treatment .…”

Section: Effects Of the Npffr System On The Stress Response And Anxietysupporting

confidence: 68%

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

Kim

2016

J Neuroendocrinology

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RFamide-related peptides (RFRPs) have been heavily implicated in the control of reproductive function subsequent to their discovery more than 16 years ago. However, recent studies using genetic and pharmacological tools have challenged their importance in regulating the hypothalamic-pituitary-gonadal axis. It is generally accepted that RFRPs act as part of a wider RFamide system, which involves two receptors, called the neuropeptide FF receptors (NPFFR1 and R2), and includes the closely-related neuropeptide NPFF. NPFF has been studied ever since the 1980s and many of the functions of NPFF are also shared by RFRPs. The current review questions whether these functions of NPFF are indeed specific to just NPFF alone and presents evidence from both neuroendocrine and pharmacological perspectives. Furthermore, recently emerging new functions of RFRPs are discussed with the overall goal of clarifying the functions of RFRPs beyond the hypothalamic-pituitary-gonadal axis.

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Section: Effects Of the Npffr System On The Stress Response And Anxietysupporting

confidence: 68%

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

Kim

2016

J Neuroendocrinology

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“…Our previous studies showed that NPAF and KP-13 increase the plasma corticosterone levels and induce anxiety-like behavior in elevated plus maze test in rats [13,29]. It has also been demonstrated that antagonism of NPFF receptors attenuates the ethanol and the amphetamine withdrawal-induced anxiety-like behaviors in rats [30,31]. Taking into consideration the present and the previous studies we can conclude that RFamide neuropeptides are involved in anxiety and there are no species differences between rats and mice in terms of NPAF-induced anxiety-like behavior.…”

Section: Discussionmentioning

confidence: 98%

Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice

Palotai

Telegdy

Tanaka

et al. 2014

Behavioural Brain Research

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“…NPFF receptor antagonists have been reported to confer anxiolytic effects. Treatment with RF9 reverses amphetamine withdrawal-induced anxiety-like behavior [ 46 ], and dansyl-PQRamide (a putative NPFF antagonist) reduces anxiety responses triggered by ethanol withdrawal [ 47 ]. We have recently reported that chronic stimulation of NPFFR2 triggers hyperactivity of the HPA axis and disrupts hippocampal feed-back regulation resulting in depression-like behaviors in mice [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents

Lin

Hong

et al. 2017

IJMS

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Neuropeptide FF (NPFF) belongs to the RFamide family and is known as a morphine-modulating peptide. NPFF regulates various hypothalamic functions through two receptors, NPFFR1 and NPFFR2. The hypothalamic-pituitary-adrenal (HPA) axis participates in physiological stress response by increasing circulating glucocorticoid levels and modulating emotional responses. Other RFamide peptides, including neuropeptide AF, neuropeptide SF and RFamide related peptide also target NPFFR1 or NPFFR2, and have been reported to activate the HPA axis and induce anxiety- or depression-like behaviors. However, little is known about the action of NPFF on HPA axis activity and anxiety-like behaviors, and the role of the individual receptors remains unclear. In this study, NPFFR2 agonists were used to examine the role of NPFFR2 in activating the HPA axis in rodents. Administration of NPFFR2 agonists, dNPA (intracerebroventricular, ICV) and AC-263093 (intraperitoneal, IP), time-dependently (in rats) and dose-dependently (in mice) increased serum corticosteroid levels and the effects were counteracted by the NPFF receptor antagonist, RF9 (ICV), as well as corticotropin-releasing factor (CRF) antagonist, α-helical CRF(9-41) (intravenous, IV). Treatment with NPFFR2 agonist (AC-263093, IP) increased c-Fos protein expression in the hypothalamic paraventricular nucleus and induced an anxiogenic effect, which was evaluated in mice using an elevated plus maze. These findings reveal, for the first time, that the direct action of hypothalamic NPFFR2 stimulates the HPA axis and triggers anxiety-like behaviors.

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Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats

Cited by 31 publications

References 87 publications

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice

NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents

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