Modulation of Nociceptive Thresholds by Vasopressin in the Brattleboro and Normal Rat*

Bodnar, Richard J.; Wallace, Margaret M.; Kordower, Jeffrey H.; Nilaver, Gajanan; Cort, J. H.; Zimmerman, Earl A.

doi:10.1111/j.1749-6632.1982.tb37491.x

Cited by 28 publications

(14 citation statements)

References 6 publications

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“…VP was also shown to increase threshold temperature of TF. This finding further confirms the reported data that s.c. VP prolongs latency of TF (BERNTSON and BERSON, 1980;BODNAR et al, 1982;BERSON et al, 1983). In the present data the minimum dose of iv.…”

supporting

confidence: 49%

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Plasma vasopressin is not involved in footshock-induced analgesia in rats.

Hamamura

Onaka

1988

Jpn.J.Physiol

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Summary Whether plasma vasopressin (VP) mediates footshockinduced analgesia was examined in conscious rats. Footshocks significantly increased threshold temperature of tail flick and plasma VP as reported previously. Intravenous VP increased the threshold only in doses that are considered to elevate plasma VP to a level more than 500 times higher than that after footshocks. In addition, posterior pituitary stimulation increased plasma VP to a level ten times higher than that after footshocks but did not significantly change the threshold. It is therefore highly likely that plasma VP is not involved in footshock-induced analgesia.

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supporting

confidence: 49%

“…Footshocks have also been shown to increase plasma immunoreactive vasopressin (ir-VP) (ONAKA et al, 1986). A large amount of subcutaneous VP has been demonstrated to prolong latency of TF (BERNTSON and BERSON, 1980;BODNAR et al, 1982;BERSON et al, 1983). It is therefore possible that plasma VP may mediate footshock-induced analgesia.…”

mentioning

confidence: 99%

Plasma vasopressin is not involved in footshock-induced analgesia in rats.

Hamamura

Onaka

1988

Jpn.J.Physiol

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“…In addition to the capacity of administered AVP to show antinociception, studies on nociceptive conditions in Brattleboro rats, which are naturally deficient in AVP, are informative concerning the role of AVP in pain sensitivity. Brattleboro rats have a hyperanalgesic state in flinch-jump threshold test and impaired stress analgesia (Bodnar et al, 1982). It could be inferred from these observations that AVP plays a role as an endogenous analgesic substance.…”

Section: Discussionmentioning

confidence: 76%

Exaggerated Response of a Vasopressin–Enhanced Green Fluorescent Protein Transgene to Nociceptive Stimulation in the Rat

Suzuki

Kawasaki²,

Ohnishi³

et al. 2009

J. Neurosci.

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Nociceptive stimulation elicits neuroendocrine responses such as arginine vasopressin (AVP) release as well as activation of the hypothalamo-pituitary-adrenal axis. We have generated novel transgenic rats expressing an AVP-enhanced green fluorescent protein (eGFP) fusion gene, and we examined the effects of nociceptive stimulation on transgene expression in the hypothalamus after subcutaneous injection of saline or formalin into the bilateral hindpaws in these rats. We have assessed (1) AVP levels in plasma and the changes of eGFP mRNA and AVP heteronuclear RNA (hnRNA) in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) using in situ hybridization histochemistry, (2) gene expression changes in distinct magnocellular and parvocellular divisions of the PVN, (3) eGFP fluorescence in the SON, the PVN, the median eminence (ME), and the posterior pituitary gland (PP). Plasma AVP levels were significantly increased 15 min after formalin injection. In the same time period, the AVP hnRNA levels in the PVN were increased, especially in the parvocellular division of the PVN in formalin-injected rats. In the same region, eGFP mRNA levels after formalin injection were also significantly increased to a much greater extent than those of AVP hnRNA. The eGFP fluorescence in the SON, the PVN, the ME, and the PP was markedly increased in formalin-injected rats and especially increased in the parvocellular divisions of the PVN. Together, our results demonstrate robust and rapid changes in the expression of the AVP-eGFP transgene in the rat hypothalamus after acute nociceptive stimulation.

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“…When examined using the flinch-jump threshold test, Brattleboro rats were in a hyperalgesic state and stress analgesia was impaired in comparison to controls (41). These analgesic deficits observed in Brattleboro rats was vasopressin-dependent; LVP introduced into the lateral cerebral ventricle, or subcutaneously at a high dose, induced an antinociceptive effect (42).…”

Section: Effect Of Avp In Pain Perceptionmentioning

confidence: 99%

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Vasopressin and Pain Perception

Koshimizu

Tsujimoto

2009

J Pharmacol Sci

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Abstract. Arginine vasopressin (AVP) activates three vasopressin receptors and it also has an agonistic activity on the oxytocin receptor. For an accurate description of the target receptor subtype(s) responsible for complex AVP and oxytocin actions, a careful evaluation of ligand specificity and receptor activities are required, particularly when these receptors are co-expressed in the central nervous system. Previous studies suggest that AVP plays a regulatory role in nociception through the direct activation of central vasopressin receptors and also through the receptors that reside in the peripheral tissues. Genetically altered rodent models, including the AVP-deficient mutant Brattleboro rat and gene knockout mice lacking an endogenous opioid peptide, advanced the understanding of the interactions between the pain perception process and AVP system. This report reviews previous findings in this important field and reconciles them with the findings of recent gene knockout / knockdown studies.

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Modulation of Nociceptive Thresholds by Vasopressin in the Brattleboro and Normal Rat*

Cited by 28 publications

References 6 publications

Plasma vasopressin is not involved in footshock-induced analgesia in rats.

Plasma vasopressin is not involved in footshock-induced analgesia in rats.

Exaggerated Response of a Vasopressin–Enhanced Green Fluorescent Protein Transgene to Nociceptive Stimulation in the Rat

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Vasopressin and Pain Perception

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