1990
DOI: 10.1111/j.1749-6632.1990.tb32018.x
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Modulation of Noradrenaline Release by Activation of Presynaptic β‐Adrenoceptors in the Cardiovascular Systema

Abstract: Peripheral sympathetic nerve terminals in many tissues, but not all, are endowed with beta-adrenoceptors. Activation of these result in an enhancement of noradrenaline release evoked by electrical nerve stimulation. These so-called presynaptic beta-adrenoceptors are possibly located on the outer surface of the varicosity of the noradrenergic nerves. A postsynaptic location, however, is also a possibility. The presynaptic beta-adrenoceptors appear to be of the beta 2-adrenoceptor subtype. However, specific clas… Show more

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Cited by 26 publications
(24 citation statements)
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“…This is supported by a previous study demonstrating that an increase in preganglionic adrenal sympathetic nerve activity during coronary occlusion has a significant positive relationship with rises in arterial plasma NEp and Ep, which are abolished by bilateral adrenalectomy [16]. It has been reported, however, that presynaptic ␤-adrenoceptors on sympathetic nerve terminals that have a facilitatory effect on NEp release from the sympathetic terminals may be activated by circulating Ep [17,18]. If this is so, bilateral adrenalectomy would cause a generalized attenuation of the responses in plasma NEp.…”
Section: Discussionsupporting
confidence: 70%
“…This is supported by a previous study demonstrating that an increase in preganglionic adrenal sympathetic nerve activity during coronary occlusion has a significant positive relationship with rises in arterial plasma NEp and Ep, which are abolished by bilateral adrenalectomy [16]. It has been reported, however, that presynaptic ␤-adrenoceptors on sympathetic nerve terminals that have a facilitatory effect on NEp release from the sympathetic terminals may be activated by circulating Ep [17,18]. If this is so, bilateral adrenalectomy would cause a generalized attenuation of the responses in plasma NEp.…”
Section: Discussionsupporting
confidence: 70%
“…The decrease in stimulation-evoked 3H overflow observed at the highest concentrations of rauwolscine may be due to a local anesthetic action. Rauwolscine is stereoisomer of yo himbine, which is known to have local anes thetic properties [22], Adrenaline can activate presynaptic padrenoceptors in a variety of tissues [8], However, the present results do not support the proposal that adrenaline can activate presynaptic facilitatory P-adrenoceptors in the rabbit central ear artery. Thus, adrena line did not enhance the stimulation-evoked 3H overflow from ear artery preloaded with 3H-noradrenaline ( fig.…”
Section: Discussioncontrasting
confidence: 56%
“…Adrenaline may be implicated in the development of essential hypertension by acting on presynaptic p2-adrenoceptors and hereby facilitate depolari zation-evoked noradrenaline release [5,6,[14][15][16]. In many tissues, exogenously ap plied adrenaline produces a biphasic concen tration-dependent effect on transmitter re lease: at low concentrations a facilitation is observed and at higher ones an attenuation is seen [6,8], The aim of the present investi gation was to study the ability of adrenaline to activate presynaptic inhibitory ob-adrenoceptors and facilitatory Pa-adrenoceptors in the rabbit ear artery.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, as demonstrated in the present study, β-blockade attenuates the increase in arterial plasma noradrenaline during core cooling. Since agonist occupation of presynaptic β-adrenoceptors on sympathetic nerve terminals augments the amount of exocytosis for a given increase in nerve traffic [24,25], β-adrenoceptor blockade might limit cold-induced, sympathetically mediated delivery of noradrenaline to adrenoceptors in the heart and vasculature.…”
Section: Discussionmentioning
confidence: 99%