2017
DOI: 10.3390/antiox6040073
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Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Abstract: Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect … Show more

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Cited by 81 publications
(64 citation statements)
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References 154 publications
(231 reference statements)
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“…As mentioned above, despite the high content of potential Nrf2‐inducers in MCFE, the identification of the compound responsible for the observed biological activities was not within the scopes of the present study. This is the first time that Nrf2‐mediated antioxidant activity of MCFE have been investigated in vivo, and the obtained results are consistent with literature data reporting the ability plant‐based Nrf2 activators …”
Section: Resultssupporting
confidence: 91%
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“…As mentioned above, despite the high content of potential Nrf2‐inducers in MCFE, the identification of the compound responsible for the observed biological activities was not within the scopes of the present study. This is the first time that Nrf2‐mediated antioxidant activity of MCFE have been investigated in vivo, and the obtained results are consistent with literature data reporting the ability plant‐based Nrf2 activators …”
Section: Resultssupporting
confidence: 91%
“…This is the first time that Nrf2mediated antioxidant activity of MCFE have been investigated in vivo, and the obtained results are consistent with literature data reporting the ability plant-based Nrf2 activators. [3]…”
Section: Mcfe Intake Improves Colonic Redox Status and Protect Againsmentioning
confidence: 99%
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“…The neuroprotective effects of red wine are mainly due to the presence of polyphenols such as quercetin, myricetin, catechins, tannins, anthocyanidins, resveratrol, and ferulic acid (70). These polyphenols induce endogenous antioxidant Defense mechanism by modulating transcription factors such as the nuclear factor erythroid 2-related factor 2 (Nrf2) and improve cognitive functions (71).…”
Section: Red Winementioning
confidence: 99%