Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex

Koborssy, Dolly Al; Palouzier-Paulignan, Brigitte; Canova, Vincent; Thévenet, M; Fadool, James M.; Julliard, A

doi:10.1007/s00429-018-1776-0

Cited by 27 publications

(25 citation statements)

References 112 publications

(158 reference statements)

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“…In fact, icv administration of insulin decreased odour responses in the pyramidal neurons of the piriform cortex 32 . Further, insulin injection into the piriform cortex prevented odour discrimination, while insulin application to a cortical slice suppressed the firing activity of piriform cortex neurons 33 . While knowledge of feeding-related signals in olfactory cortical areas remains limited, these reports, and the molecular expression results of the present study, support the hypothesis that feeding-related neuromodulatory signals strongly influence the function of olfactory cortical areas and crucially regulate odour-mediated feeding behaviours.…”

Section: Discussionmentioning

confidence: 94%

Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system

Nogi

Ahasan

Murata

et al. 2020

Sci Rep

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Various neural systems cooperate in feeding behaviour, and olfaction plays crucial roles in detecting and evaluating food objects. While odour-mediated feeding behaviour is highly adaptive and influenced by metabolic state, hedonic cues and learning processes, the underlying mechanism is not well understood. Feeding behaviour is regulated by orexigenic and anorexigenic neuromodulatory molecules. However, knowledge of their roles especially in higher olfactory areas is limited. Given the potentiation of feeding behaviour in hunger state, we systemically examined the expression of feeding-related neuromodulatory molecules in food-restricted mice through quantitative PCR, in the olfactory bulb (OB), olfactory tubercle (OT), and remaining olfactory cortical area (OC). The OT was further divided into attraction-related anteromedial, aversion-related lateral and remaining central regions. Examination of 23 molecules including neuropeptides, opioids, cannabinoids, and their receptors as well as signalling molecules showed that they had different expression patterns, with many showing elevated expression in the OT, especially in the anteromedial and central OT. Further, in mice trained with odour-food association, the expression was significantly altered and the increase or decrease of a given molecule varied among areas. These results suggest that different olfactory areas are regulated separately by feeding-related molecules, which contributes to the adaptive regulation of feeding behaviour.

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Section: Discussionmentioning

confidence: 94%

Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system

Nogi

Ahasan

Murata

et al. 2020

Sci Rep

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“…Fasting results in an increased perception of some food-related odors in humans [33] and olfactory sensitivity to a neutral odor increases in fasted rats [7]. The neural mechanisms underlying these behavioral observations are not clear, even though many studies have focused on this issue and a lot of data have been collected [16,17,21,[34][35][36][37]. Since the OB is the first olfactory center and plays critical roles in odor information processing, most of the studies of different nutritional states examined neural activity in the OB [2,[16][17][18]34,37].…”

Section: Discussionmentioning

confidence: 99%

Excitability of Neural Activity is Enhanced, but Neural Discrimination of Odors is Slightly Decreased, in the Olfactory Bulb of Fasted Mice

Liu

Chen

et al. 2020

Genes

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Olfaction and satiety status influence each other: cues from the olfactory system modulate eating behavior, and satiety affects olfactory abilities. However, the neural mechanisms governing the interactions between olfaction and satiety are unknown. Here, we investigate how an animal’s nutritional state modulates neural activity and odor representation in the mitral/tufted cells of the olfactory bulb, a key olfactory center that plays important roles in odor processing and representation. At the single-cell level, we found that the spontaneous firing rate of mitral/tufted cells and the number of cells showing an excitatory response both increased when mice were in a fasted state. However, the neural discrimination of odors slightly decreased. Although ongoing baseline and odor-evoked beta oscillations in the local field potential in the olfactory bulb were unchanged with fasting, the amplitude of odor-evoked gamma oscillations significantly decreased in a fasted state. These neural changes in the olfactory bulb were independent of the sniffing pattern, since both sniffing frequency and mean inhalation duration did not change with fasting. These results provide new information toward understanding the neural circuit mechanisms by which olfaction is modulated by nutritional status.

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“…28 activity indicate that leptin may affect the representation transferred from the OB to higher brain centers for further odor discrimination and cognition. Although the mechanism by which insulin affects the activity of piriform cortex has been revealed in recent studies, 15,52 it will be interesting to investigate how leptin modulates neural activity in piriform cortex in future studies. 42,49 The odor-evoked beta oscillation, which is thought to reflect the interaction between the OB and piriform cortex, 50,51 was decreased after administration of leptin, indicating that the communication between the OB and piriform cortex may be disrupted by leptin.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is likely that the decreased odor response of the mitral cells and the weaker communication between the OB and piriform cortex will alter neural activity in piriform cortex, impairing odor discrimination performance during the go/no-go task. Although the mechanism by which insulin affects the activity of piriform cortex has been revealed in recent studies, 15,52 it will be interesting to investigate how leptin modulates neural activity in piriform cortex in future studies.…”

Section: Discussionmentioning

confidence: 99%

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Sun

Ke-ke

et al. 2019

Acta Physiologica

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Aim Leptin is an important peptide hormone that regulates food intake and plays a crucial role in modulating olfactory function. Although a few previous studies have investigated the effect of leptin on odor perception and discrimination in rodents, research on the neural basis underlying the behavioral changes is lacking. Here we study how leptin affects behavioral performance during a go/no‐go task and how it modulates neural activity of mitral/tufted cells in the olfactory bulb, which plays an important role in odor information processing and representation. Methods A go/no‐go odor discrimination task was used in the behavioral test. For in vivo studies, single unit recordings, local field potential recordings and fiber photometry recordings were used. For in vitro studies, we performed patch clamp recordings in the slice of the olfactory bulb. Results Behaviorally, leptin affects performance and reaction time in a difficult odor‐discrimination task. Leptin decreases the spontaneous firing of single mitral/tufted cells, decreases the odor‐evoked beta and high gamma local field potential response, and has bidirectional effects on the odor‐evoked responses of single mitral/tufted cells. Leptin also inhibits the population calcium activity in genetically identified mitral/tufted cells and granule cells. Furthermore, in vitro slice recordings reveal that leptin inhibits mitral cell activity through direct modulation of the voltage‐sensitive potassium channel. Conclusions The behavioral reduction in odor discrimination observed after leptin administration is likely due to decreased neural activity in mitral/tufted cells, caused by modulation of potassium channels in these cells.

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Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex

Cited by 27 publications

References 112 publications

Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system

Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system

Excitability of Neural Activity is Enhanced, but Neural Discrimination of Odors is Slightly Decreased, in the Olfactory Bulb of Fasted Mice

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

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