Modulation of pathways regulating both the invasiveness and apoptosis in rheumatoid arthritis synovial fibroblasts

Pap, Thomas; Cinski, Antje; Baier, Anja; Gay, Steffen; Meinecke, Ingmar

doi:10.1016/s1297-319x(03)00162-3

Cited by 4 publications

(1 citation statement)

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“…It has been suggested that a reduced rate of programmed cell death provides one explanation for pannus formation in that the inability of RA-FLS to undergo apoptosis contributes both the development of synovial hyperplasia and extends the life span of these fibroblasts facilitating the destruction of cartilage and bone [5,6]. In view of most recent advances in this field, this review provides a summary of the currently available data on the role of apoptotic pathways in RA.…”

Section: Introductionmentioning

confidence: 99%

Cell death in rheumatoid arthritis

2009

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Apoptosis plays a pivotal role in tissue homoeostasis both under physiological and pathological conditions and several studies have shown that some characteristic changes in the composition and structure of the inflamed synovial membrane in rheumatoid arthritis (RA) are linked to an altered apoptotic response of synovial cells. As a result, a hyperplastic synovial tissue is generated that mediates the progressive destruction of articular cartilage and bone. In addition to inflammatory cells, these changes most prominently affect resident fibroblast-like cells that have been demonstrated to be of utmost importance for joint destruction. Once activated, these cells pass through prominent molecular changes resulting in an aggressive, invasive behaviour. Research of the past years has identified different mechanisms that prevent synovial cells in RA from apoptosis. They include changes in the mitochondrial pathway as well as altered expression of downstream modulators of death receptors and transcriptional regulators such as NFkappaB. This review summarises our recent progress in understanding aberrant apoptosis in the RA synovial membrane and points to possibilities of intervening specifically with this aspect of the pathogenesis of RA.

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Section: Introductionmentioning

confidence: 99%