Modulation of phenotypic and functional maturation of murine dendritic cells (DCs) by purified Achyranthes bidentata polysaccharide (ABP)

Zou, Yaxuan; Meng, Jingjuan; Chen, Wenna; Liu, Jingling; Li, Xuan; Li, Weiwei; Lu, Cuihua; Shan, Fengping

doi:10.1016/j.intimp.2011.03.006

Cited by 50 publications

(28 citation statements)

References 29 publications

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“…The upregulation of co-stimulatory molecules and MHC I/II can promote T cell activity (Miga et al, 2000). Zou et al (2011) have demonstrated that Achyranthes bidentata polysaccharides can modulate DCs and induce their maturation. Zhang et al (2010) and Du et al (2012) have confirmed that Astragalus polysaccharide can enhance cellular and humoral immune responses in mice via activation of DCs and lead to their maturation (Du et al, 2012;Zhang et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

Feng

Fan

et al. 2015

Immunological Investigations

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This study was conducted to evaluate the adjuvant potential of sulfated Radix Cyathulae officinalis Kuan polysaccharides (sRCPS) and their effects on specific cellular and humoral immune responses to hepatitis B subunit vaccine in mice. Our data demonstrated that sRCPS significantly promoted the rHBsAg-specific IgG, IgG1, IgG2a, and IgG2b antibody titers, the activities of natural killer cells (NK) and cytotoxic T lymphocytes (CTL), T cells proliferation, and phagocytic capacity of peritoneal macrophages. Furthermore, sRCPS increased the levels of IL-4, IL-2, and IFN-γ in CD4(+)T cells and the level of IFN-γ in CD8(+)T cells. In addition, sRCPS enhanced the expression of CD40(+), CD80(+), CD86(+), MHC I and MHC II in dendritic cells (DCs) and upregulated the mRNA levels of MHC I, MHC II. sRCPS downregulated the frequency of CD4(+)CD25(+)Foxp3(+) Treg cells. sRCPS increased both cellular and humoral immune responses by upregulating DC maturation, and suppressing the frequency of Treg cells.

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Section: Discussionmentioning

confidence: 99%

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

Feng

Fan

et al. 2015

Immunological Investigations

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“…In addition, our research group found ABP could induce DCs maturation. 16 Given the immunoregulatory characteristics of RGMa in other immune responses, we speculate that this molecule may play an important role in DCs function. Therefore, we added the RGMa-neutralizing antibody into cell culture medium to inhibit the expression of this molecule and explored the influences of RGMa on DCs function.…”

Section: Introductionmentioning

confidence: 93%

Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS

Gao

Zhai

et al. 2016

Human Vaccines & Immunotherapeutics

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Repulsive guidance molecule a (RGMa) is an axonal guidance molecule that has recently found to exert function in immune system. This study evaluated the function of RGMa in modulation of dendritic cells (DCs) function stimulated with Achyranthes bidentata polysaccharide (ABP) and lipopolysaccharide (LPS) using a RGMa-neutralizing antibody. Compared with the Control-IgG/ABP and Control-IgG/LPS groups, DCs in the Anti-RGMa/ABP and Anti-RGMa/LPS groups 1) showed small, round cells with a few cell processes and organelles, and many pinocytotic vesicles; 2) had decreased MHC II, CD86, CD80, and CD40 expression; 3) displayed the decreased IL-12p70, IL-1b and TNF-a levels and increased IL-10 secretion; 4) had a high percentage of FITC-dextran uptake; and 5) displayed a reduced ability to drive T cell proliferation and reinforced T cell polarization toward a Th2 cytokine pattern. We conclude that DCs treated with RGMa-neutralizing antibodies present with tolerogenic and immunoregulatory characteristics, which provides new insights into further understanding of the function of RGMa.

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“…DC. promoted the maturation of DCs revealed by the increased expressions of co-stimulatory and MHC molecules and pro-inflammatory cytokine production including IL-12 and TNF-α, decreased the ability of endocytosis, and enhanced the capacity of DCs on the stimulation of T cell proliferation and antigen presenting Shao et al, 2006;Zou et al, 2011). A. bidentata Blume polysaccharides-treated mice enhanced anti-malarial immunity and developed more myeloid (CD11c þ CD11b þ ) and plasmacytoid DCs (CD11c þ CD45R þ /B220 þ ) than control mice.…”

Section: Polysaccharide Of Chmmentioning

confidence: 99%

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

Zhang

2015

Journal of Ethnopharmacology

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Modulation of phenotypic and functional maturation of murine dendritic cells (DCs) by purified Achyranthes bidentata polysaccharide (ABP)

Cited by 50 publications

References 29 publications

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

SulfatedRadix Cyathulae officinalisPolysaccharides Act as Adjuvant via Promoting the Dendritic Cell Maturation and Suppressing Treg Frequency

Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

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