Modulation of plasma cholesteryl ester transfer protein activity by unsaturated fatty acids in Tunisian type 2 diabetic women

Smaoui, M.; Hammami, S.; Attia, Nebil; Chaaba, R.; Abid, N.; Kilani, N.; Kchaou, Hédi; Mahjoub, S.; Abid, M.; Hammami, Mohamed

doi:10.1016/j.numecd.2005.05.011

Cited by 17 publications

(13 citation statements)

References 45 publications

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“…CETP may be antiatherogenic in that it increases the rate of reverse cholesterol transport, but it may be proatherogenic in that it transports CE from HDL, which is protective, to VLDL and LDL, which are atherogenic (33). Studies in humans have shown that the intakes of SFAs (34 -36) and trans fatty acids (37,38) increase CETP, whereas the intake of MUFAs decreases (39) and the intake of PUFAs decreases (40) or has no effect on CETP (13,35,41). The lack of a significant effect of diet on CETP in the present study may have been due to the similar plasma MUFA composition of the 3 experimental diets and also to the relatively small sample size of the study.…”

Section: Discussionmentioning

confidence: 45%

“…Both CETP and SCD have been shown to be regulated by fatty acids (13,14) and are important potential mechanisms to explain how pistachios affect lipids and lipoproteins. To our knowledge, this is the first randomized controlled feeding study to assess potential mechanisms that may account for the lipid and lipoprotein responses to a cholesterol-lowering diet with varying doses of pistachios.…”

Section: Introductionmentioning

confidence: 99%

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Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study

Gebauer

West

Kay

et al. 2008

The American Journal of Clinical Nutrition

129

155

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Background: Nut consumption lowers cardiovascular disease (CVD) risk. Studies are lacking about the effects of pistachios, a nutrient-dense nut, on CVD risk factors, dose-response relations, and lipid-lowering mechanisms. Objective: We evaluated the effects of 2 doses of pistachios, added to a lower-fat diet, on lipids and lipoproteins, apolipoprotein (apo)-defined lipoprotein subclasses, and plasma fatty acids. To investigate the mechanisms of action, we measured cholesteryl ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD). Design: In a randomized crossover controlled-feeding study, 28 individuals with LDL cholesterol ͧ 2.86 mmol/L consumed 3 isoenergetic diets for 4 wk each. Baseline measures were assessed after 2 wk of a typical Western diet. The experimental diets included a lower-fat control diet with no pistachios [25% total fat; 8% saturated fatty acids (SFAs), 9% monounsaturated fatty acids (MUFAs), and 5% polyunsaturated fatty acids (PUFAs)], 1 serving/d of a pistachio diet (1 PD; 10% of energy from pistachios; 30% total fat; 8% SFAs, 12% MUFAs, and 6% PUFAs), and 2 servings/d of a pistachio diet (2 PD; 20% of energy from pistachios; 34% total fat; 8% SFAs, 15% MUFAs, and 8% PUFAs). Results: The 2 PD decreased (P 0.05 compared with the control diet) total cholesterol (Ҁ8%), LDL cholesterol (Ҁ11.6%), non-HDL cholesterol (Ҁ11%), apo B (Ҁ4%), apo B/apo A-I (Ҁ4%), and plasma SCD activity (Ҁ1%). The 1 PD and 2 PD, respectively, elicited a dose-dependent lowering (P 0.05) of total cholesterol/ HDL cholesterol (Ҁ1% and Ҁ8%), LDL cholesterol/HDL cholesterol (Ҁ3% and Ҁ11%), and non-HDL cholesterol/HDL cholesterol (Ҁ2% and Ҁ10%). Conclusions: Inclusion of pistachios in a healthy diet beneficially affects CVD risk factors in a dose-dependent manner, which may reflect effects on SCD.Am J Clin Nutr 2008;88:651-9.

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Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study

Gebauer

West

Kay

et al. 2008

The American Journal of Clinical Nutrition

129

155

View full text Add to dashboard Cite

show abstract

“…A clinical trial using CETP inhibitor has failed to show the protective effect for CHD, although participants in this study showed an extremely HDL-C elevation almost equivalent to very high HDL-C level in our study 30) . Some previous studies have shown mild inverse or no association between HDL-C concentrations and plasma CETP activity [31][32][33] . Moreover, plasma CETP activity showed inverse correlation with CVD risk independent of HDL-C levels 34) .…”

Section: Resultsmentioning

confidence: 92%

The Relationship between Very High Levels of Serum High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in a 20-Year Follow-Up Study of Japanese General Population

Hirata

Okamura

Sugiyama

et al. 2016

J Atheroscler Thromb

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“…Besides, high CETP activity has been demonstrated in obese and diabetic subjects [23], [24]. Previous studies have also shown an association between this polymorphism and the metabolic syndrome [25], independently of the well-known effect on HDLc concentrations and insulin resistance [26], a fact that suggests a possible role of CETP on glucose metabolism.…”

Section: Discussionmentioning

confidence: 92%

Interaction between Cholesteryl Ester Transfer Protein and Hepatic Lipase Encoding Genes and the Risk of Type 2 Diabetes: Results from the Telde Study

et al. 2011

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Background and AimDiabetic dyslipidaemia is common in type 2 diabetes (T2D) and insulin resistance and often precedes the onset of T2D. The Taq1B polymorphism in CETP (B1 and B2 alleles) (rs708272) and the G-250A polymorphism in LIPC (rs2070895) are associated with changes in enzyme activity and lipid concentrations. Our aim was to assess the effects of both polymorphisms on the risk of T2D.Methods and ResultsIn a case-control study from the population-based Telde cohort, both polymorphisms were analysed by PCR-based methods. Subjects were classified, according to an oral glucose tolerance test, into diabetic (N = 115) and pre-diabetic (N = 116); 226 subjects with normal glucose tolerance, matched for age and gender, were included as controls. Chi-square (comparison between groups) and logistic regression (identification of independent effects) were used for analysis. The B1B1 Taq1B CETP genotype frequency increased with worsening glucose metabolism (42.5%, 46.1% and 54.3% in control, IGR and diabetic group; p = 0.042). This polymorphism was independently associated with an increased risk of diabetes (OR: 1.828; IC 95%: 1.12–2.99; p = 0.016), even after adjusting by confounding variables, whereas the LIPC polymorphism was not. Regarding the interaction between both polymorphisms, in the B1B1 genotype carriers, the absence of the minor (A) allele of the LIPC polymorphism increased the risk of having diabetes.ConclusionThe presence of the B1B1 Taq1B CETP genotype contributes to the presence of diabetes, independently of age, sex, BMI and waist. However, among carriers of B1B1, the presence of GG genotype of the -250 LIPC polymorphism increases this risk further.

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Modulation of plasma cholesteryl ester transfer protein activity by unsaturated fatty acids in Tunisian type 2 diabetic women

Cited by 17 publications

References 45 publications

Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study

Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study

The Relationship between Very High Levels of Serum High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in a 20-Year Follow-Up Study of Japanese General Population

Interaction between Cholesteryl Ester Transfer Protein and Hepatic Lipase Encoding Genes and the Risk of Type 2 Diabetes: Results from the Telde Study

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