Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals

Ramadan, Laila A.; Shouman, Samia A.; Sayed‐Ahmed, Mohamed M.; El-Habit, Ola H.

doi:10.1006/phrs.2000.0763

Cited by 20 publications

(13 citation statements)

References 21 publications

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“…We also observed a large increase in the levels of TGs and ChoE, which has been reported in previous studies with 6 Gy of external irradiation in rats 20 and 5 Gy of whole-body external irradiation in mice 21 . Although the levels of these lipids reverted back to normal after one radiation exposure, in our current study the 90 Sr exposure-induced increases persisted until the end of the experiment, day 30 at 5.2±0.73 Gy.…”

Section: Resultssupporting

confidence: 90%

Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography–Mass Spectrometry Approach

et al. 2015

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Despite considerable research into the environmental risks and biological effects of exposure to external beam gamma rays, incorporation of radionuclides has largely been understudied. This dosimetry and exposure risk assessment is challenging for first responders in the field during a nuclear or radiological event. Therefore, we have developed a workflow for assessing injury responses in easily obtainable biofluids, such as urine and serum, as the result of exposure to internal emitters Cesium-137 (137Cs) and Strontium-90 (90Sr) in mice. Here we report on the results of the untargeted lipidomic profiling of serum from mice exposed to 90Sr. We also compared these results to those from previously published 137Cs exposure to determine any differences in cellular responses based on exposure type. The results of this study conclude that there is a gross increase in the serum abundance of triacylglycerides and cholesterol esters, while phostaphatidylcholines and lysophosphatidylcholines displayed decreases in their serum levels post exposure at study days 4, 7, 9, 25, and 30, with corresponding average cumulative skeleton doses ranging from 1.2±0.1 Gy to 5.2±0.73 Gy. The results show significant perturbations in serum lipidome as early as 2 days post exposure and persisting until the end of the study (day 30).

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Section: Resultssupporting

confidence: 90%

Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography–Mass Spectrometry Approach

et al. 2015

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“…The tolerance of the whole liver to radiation is low, and liver damage is seen in 5-10% of patients treated 30-35 Gy to whole liver (Dawson et al, 2002;Emami et al, 1991). Although some reports (Koç et al, 2003;Ramadan et al, 2001) documented the hepatic toxicity due to abdominal irradiation, in our study biochemical, histopathological and apoptotic changes implying toxicity were not defined in liver tissue examinations.…”

Section: Discussioncontrasting

confidence: 67%

“…It was also reported that ionizing radiation affected liver and kidney functions (Agrawal et al, 2001). Acute and delayed hypoplasia or aplasia of the bone marrow and other lymphohaematopoietic organs has been observed following radiation treatment (Agrawal et al, 2001;Ramadan et al, 2001) Radiation-induced liver disease is a dose-limiting complication of liver irradiation. The tolerance of the whole liver to radiation is low, and liver damage is seen in 5-10% of patients treated 30-35 Gy to whole liver (Dawson et al, 2002;Emami et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

The effect of glutamine on radiation-induced organ damage

et al. 2005

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“…Moreover, the formation of lipid peroxidation ultimately would alter the composition of the glomerular basement membrane [86]. Evidence of radiation induced organs injury via a mechanism of oxidative stress caused by increased MDA and nitrite, reduced GSH levels and decreased activity of CAT, SOD were demonstrated by various studies [87][88][89][90][91]. Such oxidative stress was mediated through the generation of ROS that induced disturbance of membrane permeability and severe cell damage [92][93].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Aged Garlic Extract Against the Oxidative Stress Induced by Acute Ionizing Irradiation on Hepatic Antioxidant Enzymes in Rats

Bertrand¹,

Pascal²,

Désiré³

et al. 2016

EJCBS

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Ionizing radiations damage cells, tissues and organs among which the liver through a cascade of molecular events that are triggered by reactive oxygen species (ROS), lipid peroxidation and nitrogen species (NS). Aged Garlic Extract (AGE) has been demonstrated to possess free radical scavenging capacity and antioxidant activity. Therefore, the present study has been focused in analyzing the properties of AGE against the lipid peroxidation and oxidative damages of rat liver tissues induced by acute radiation. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoïc Acid. Then, biochemical analyses, lipid peroxidation, total Protein and antioxidants assessment were made from blood samples and liver tissue homogenates. Exposure of rats to gamma radiation caused a significant increase in the level of Malondialdehyde, Nitrite, transaminase enzymes, alkaline phosphatase, and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin) level while a significant decrease was recorded in serum total proteins, glutathione content, superoxide dismutase, catalase activities and total protein level. AGE treated rats revealed a significant improvement in all previous parameters. From these results, it can be concluded that AGE may have significant anti-radiation properties in rat's liver after radiation exposure.

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Modulation of radiation-induced organs toxicity by cremophor-el in experimental animals

Cited by 20 publications

References 21 publications

Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography–Mass Spectrometry Approach

Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography–Mass Spectrometry Approach

The effect of glutamine on radiation-induced organ damage

Protective Effect of Aged Garlic Extract Against the Oxidative Stress Induced by Acute Ionizing Irradiation on Hepatic Antioxidant Enzymes in Rats

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