Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis

Waterhouse, Barry D.; Azizi, Saara-Anne; Burne, Richard A.; Woodward, Donald J.

doi:10.1016/0006-8993(90)91422-d

Cited by 183 publications

(132 citation statements)

References 46 publications

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“…This function can have many implementations, including selectively regulating neural responses to weak sensory stimuli, discriminating an ecologically important stimulus from background activity (Gaucher and Edeline, 2015), and adapting out static inputs in favor of dynamic ones. These selection processes use noradrenergic modulation of sensory regions in various ways, including both "opening the gate" for weak sensory inputs in some circumstances (Waterhouse et al, 1988(Waterhouse et al, , 1990Jiang et al, 1996;Ciombor et al, 1999) and suppressing them in others (Manunta and Edeline, 1997;Zitnik et al, 2013). The present data extend our understanding of this system both outwardly, by demonstrating that even the synaptic output of primary sensory neurons can be influenced by LC and CBL amygdala activity (Fig.…”

Section: Circuit-level Mechanismsmentioning

confidence: 99%

Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus

Fast

McGann

2017

J. Neurosci.

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Fear-and stress-induced activity in the amygdala has been hypothesized to influence sensory brain regions through the influence of the amygdala on neuromodulatory centers. To directly examine this relationship, we used optical imaging to observe odor-evoked activity in populations of olfactory bulb inhibitory interneurons and of synaptic terminals of olfactory sensory neurons (the primary sensory neurons of the olfactory system, which provide the initial olfactory input to the brain) during pharmacological inactivation of amygdala and locus coeruleus (LC) in mice. Although the amygdala does not directly project to the olfactory bulb, joint pharmacological inactivation of the central, basolateral, and lateral nuclei of the amygdala nonetheless strongly suppressed odor-evoked activity in GABAergic inhibitory interneuron populations in the OB. This suppression was prevented by inactivation of LC or pretreatment of the olfactory bulb with a broad-spectrum noradrenergic receptor antagonist. Visualization of synaptic output from olfactory sensory neuron terminals into the olfactory bulb of the brain revealed that amygdalar inactivation preferentially strengthened the odor-evoked synaptic output of weakly activated populations of sensory afferents from the nose, thus demonstrating a change in sensory gating potentially mediated by local inhibition of olfactory sensory neuron terminals. We conclude that amygdalar activity influences olfactory processing as early as the primary sensory input to the brain by modulating norepinephrine release from the locus coeruleus into the olfactory bulb. These findings show that the amygdala and LC state actively determines which sensory signals are selected for processing in sensory brain regions. Similar local circuitry operates in the olfactory, visual, and auditory systems, suggesting a potentially shared mechanism across modalities.

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Section: Circuit-level Mechanismsmentioning

confidence: 99%

Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus

Fast

McGann

2017

J. Neurosci.

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“…There is an extensive literature on postsynaptic effects of NA in sensory pathways, with several investigators suggesting that NA increases signal/noise by inhibiting background neuronal firing while sparing evoked activity (Foote et al 1975;Waterhouse and Woodward 1980;Hasselmo et al 1997) or tuning sensory responses by narrowing the receptive field of sensory neurons (Waterhouse et al 1990; Figure 3 LC unit response to the conditioning context.Rats are trained to discriminate between tones of different frequencies, one of which is associated with a foot shock (CS+) and the other not (CS−). Two seconds before the presentation of either tone, a flashing light comes on and continues for the duration of the tone (2 sec).…”

Section: Contextual Cue Reminders Retrieval and The Truncated Condimentioning

confidence: 99%

Retrieval and Reconsolidation: Toward a Neurobiology of Remembering

Sara¹

2000

Learn. Mem.

843

580

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“…LC neurons are more active immediately before and during periods of arousal and vigilance (Hobson et al, 1975;Foote et al, 1980;Aston-Jones and Bloom, 1981;Rajkowski et al, 1994), and LC stimulation in anesthetized animals results in excitation of thalamocortical neurons (Steriade et al, 1993), activation of cortical EEGs (Berridge and Foote, 1991), and enhancement of responses in primary sensory neurons (Waterhouse et al, 1998). In addition, NE alters cortical sensory receptive field properties (Waterhouse et al, 1990;George, 1992;McLean and Waterhouse, 1994; Manunta and Ede- line, 1997). Local application of NE decreases spontaneous cortical activity (Foote et al, 1975;Armstrong-James and Fox, 1983) and increases and decreases the responsiveness of cortical neurons in vitro in a dose-dependent manner (Foote et al, 1975;Waterhouse et al, 1980Waterhouse et al, , 1988Kasamatsu and Heggelund, 1982;Videen et al, 1984;Devilbiss and Waterhouse, 2000).…”

Section: Noradrenergic Effects On Sensory Responsivenessmentioning

confidence: 99%

Noradrenergic Inputs Mediate State Dependence of Auditory Responses in the Avian Song System

Cardin¹,

Schmidt²

2004

J. Neurosci.

100

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Norepinephrine (NE) plays a complex role in the behavioral state-dependent regulation of sensory processing. However, the role of forebrain NE action in modulating high-order sensory activity has not been directly addressed. In this study, we take advantage of the discrete, feedforward organization of the avian song system to identify a site and mechanism of NE action underlying state-dependent modulation of sensory processing. We have developed an experimental paradigm in which brief arousal repeatedly suppresses song system auditory responsiveness. Using pharmacological manipulations in vivo, we show that infusion of ␣-adrenergic antagonists into the NIf (nucleus interfacialis of the nidopallium), an auditory forebrain area, blocks this state-dependent modulation. We also demonstrate dose-dependent enhancement and suppression of song system auditory response properties by NE and adrenergic agonists. Our results demonstrate that noradrenergic release in a single forebrain area is a mechanism underlying behavioral state-dependent regulation of auditory processing in a neural system specialized for vocal learning.

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Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis

Cited by 183 publications

References 46 publications

Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus

Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus

Retrieval and Reconsolidation: Toward a Neurobiology of Remembering

Noradrenergic Inputs Mediate State Dependence of Auditory Responses in the Avian Song System

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