Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs

Thomas, Carolin; Wurzer, Lia; Malle, Ernst; Ristow, Michael; Madreiter‐Sokolowski, Corina T.

doi:10.3389/fragi.2022.905261

Cited by 5 publications

(2 citation statements)

References 613 publications

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“…Accomplishing SOS demands comprehensive, integrated healthcare. Numerous frequently used drugs impact OS either directly or indirectly ( 183 ). This review analyzes many of these agents used to help manage CV risk through the lens of directly mitigating OS.…”

Section: Treatmentmentioning

confidence: 99%

The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress

Bale

Doneen

Leimgruber

et al. 2022

Front. Cardiovasc. Med.

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The formation of an atheroma begins when lipoproteins become trapped in the intima. Entrapped lipoproteins become oxidized and activate the innate immune system. This immunity represents the primary association between lipids and inflammation. When the trapping continues, the link between lipids and inflammation becomes chronic and detrimental, resulting in atherosclerosis. When entrapment ceases, the association between lipids and inflammation is temporary and healthy, and the atherogenic process halts. Therefore, the link between lipids and inflammation depends upon lipoprotein retention in the intima. The entrapment is due to electrostatic forces uniting apolipoprotein B to polysaccharide chains on intimal proteoglycans. The genetic transformation of contractile smooth muscle cells in the media into migratory secretory smooth muscle cells produces the intimal proteoglycans. The protein, platelet-derived growth factor produced by activated platelets, is the primary stimulus for this genetic change. Oxidative stress is the main stimulus to activate platelets. Therefore, minimizing oxidative stress would significantly reduce the retention of lipoproteins. Less entrapment decreases the association between lipids and inflammation. More importantly, it would halt atherogenesis. This review will analyze oxidative stress as the critical link between lipids, inflammation, and the pathogenesis of atherosclerosis. Through this perspective, we will discuss stopping oxidative stress to disrupt a harmful association between lipids and inflammation. Numerous therapeutic options will be discussed to mitigate oxidative stress. This paper will add a new meaning to the Morse code distress signal SOS-stopping oxidative stress.

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Section: Treatmentmentioning

confidence: 99%

The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress

Bale

Doneen

Leimgruber

et al. 2022

Front. Cardiovasc. Med.

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“…Recently, Thomas et al [ 224 ] stated that the pleiotropic effects of commonly used drugs on ROS homeostasis is an under-appreciated effect in pharmacology. Many age-related diseases such as cardiovascular and neurodegenerative diseases are associated with increased ROS production and limited defense systems against ROS.…”

Section: Recommendations and Outlookmentioning

confidence: 99%

The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review

Kuchheuser

Birringer

2022

Antioxidants

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Complementary and alternative medicine (CAM) supplements are widely used by cancer patients. Dietary supplements, vitamins and minerals, herbal remedies, and antioxidants are especially popular. In a systematic literature review, 37 studies, each including more than 1000 participants, on CAM, dietary supplement, and vitamin use among cancer patients were identified. Accordingly, cancer patients use antioxidants such as vitamin C (from 2.6% (United Kingdom) to 41.6% (United States)) and vitamin E (from 2.9% (China) to 48% (United States)). Dietary supplements and vitamins are taken for different reasons, but often during conventional cancer treatment involving chemotherapy or radiotherapy and in a self-decided manner without seeking medical advice from healthcare professionals. Drug–drug interactions with dietary supplements or vitamins involving multiple signaling pathways are well described. Since most of the anticancer drugs generate reactive oxygen species (ROS), an adaptive stress response of healthy and malignant cells, mainly driven by the Nrf-2-Keap I network, can be observed. On the one hand, healthy cells should be protected from ROS-overproducing chemotherapy and radiotherapy; on the other hand, ROS production in cancer cells is a “desirable side effect” during anticancer drug treatment. We here describe the paradoxical use of antioxidants and supplements during cancer therapy, possible interactions with anticancer drugs, and the involvement of the Nrf-2 transcription factor.

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Dataset on In-silico Evaluation of Anti-oxidant Molecules of Talinum triangulare (Jacq.) Willd. in Cerebral Ischemic Disease Using Molecular Docking Studies

et al. 2023

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Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs

Cited by 5 publications

References 613 publications

The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress

The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress

The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review

Dataset on In-silico Evaluation of Anti-oxidant Molecules of Talinum triangulare (Jacq.) Willd. in Cerebral Ischemic Disease Using Molecular Docking Studies

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