Modulation of Reactive Oxygen Species in Health and Disease

Habtemariam, Solomon

doi:10.3390/antiox8110513

Cited by 39 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transition metals such as Zn, which were counted at a relatively low weight ratio in the samples, but were detected at constant levels in all samples, can generate ROS in living organisms. ROS are involved in the complex balance of control mechanisms that contribute to cell survival or death through intracellular signal transduction and chem- ical communication between cells (Habtemariam, 2019).…”

Section: Carbon Compound Particle Analysismentioning

confidence: 99%

Analysis of Chemical Compounds of Gaseous and Particulate Pollutants from the Open Burning of Agricultural HDPE Film Waste

Kim

Choi

Kook

2021

J. People Plants Environ

View full text Add to dashboard Cite

Background and objective: Illegal open-air incineration, which is criticized as a leading source of air pollutants among agricultural activities, currently requires constant effort and attention. Countries around the world have been undertaking studies on the emission of heavy metal substances in fine dust discharged during the incineration process. A precise analytical method is required to examine the harmful effects of particulate pollutants on the human body.Methods: In order to simulate open-air incineration, the infrastructure needed for incineration tests complying with the United States Environmental Protection Agency (EPA) Method 5G was built, and a large-area analysis was conducted on particulate pollutants through automated scanning electron microscopy (SEM)-energy-dispersive X-ray spectroscopy (EDS). For the test specimen, high-density polyethylene (HDPE) waste collected by the DangJin Office located in Choongcheongnam-do was used. To increase the identifiability of the analyzed particles, the incineration experiment was conducted in an incinerator three times after dividing the film waste into 200 g specimens.Results: Among the metal particulate matters detected in the HDPE waste incineration test, transition metals included C (20.8-37.1 wt%) and O (33.7-37.9 wt%). As for other chemical matters, the analysis showed that metal particulate matters such as metalloids, alkali metals, alkaline earth metals, and transition metals reacted to C and C-O. Si, a representative metalloid, was detected at 14.8-20.8 wt%, showing the highest weight ratio except for C and O.Conclusion: In this study, the detection of metal chemicals in incinerated particulate matters was effectively confirmed through SEM-EDS. The results of this study verified that HDPE waste adsorbs metal chemicals originating from soil due to its own properties and deterioration, and that when incinerated, it emits particulate matters containing transition metals and other metals that contribute to the excessive production and reduction of reactive oxygen species.

show abstract

Section: Carbon Compound Particle Analysismentioning

confidence: 99%

Analysis of Chemical Compounds of Gaseous and Particulate Pollutants from the Open Burning of Agricultural HDPE Film Waste

Kim

Choi

Kook

2021

J. People Plants Environ

View full text Add to dashboard Cite

show abstract

“…Some of these ROS are produced during normal cellular metabolism and they have an endogenous origin, mainly by Complex I and III, but there are ROS engendered due to the influence of external factors such as radiation, UV radiation, and heavy metals [33,34]. Although normal ROS production levels play an important role in maintaining proper intracellular signaling, increased levels of ROS production or dysfunction of the cell's antioxidant defense mechanisms may be the initial trigger factor for a wide range of diseases [35,36]. Functional abnormalities in complex I, which are a consequence of gene mutations (nuclear or mtDNA), lead to increased ROS production and a decrease of the energetic cellular capacity [32,37].…”

Section: Disease-associated Defects In Oxidative Phosphorylationmentioning

confidence: 99%

Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe

Panuzzo

Jovanovski

Pergolizzi

et al. 2020

IJMS

View full text Add to dashboard Cite

Mitochondria are the main fascinating energetic source into the cells. Their number, shape, and dynamism are controlled by the cell’s type and current behavior. The perturbation of the mitochondrial inward system via stress response and/or oncogenic insults could activate several trafficking molecular mechanisms with the intention to solve the problem. In this review, we aimed to clarify the crucial pathways in the mitochondrial system, dissecting the different metabolic defects, with a special emphasis on hematological malignancies. We investigated the pivotal role of mitochondria in the maintenance of hematopoietic stem cells (HSCs) and their main alterations that could induce malignant transformation, culminating in the generation of leukemic stem cells (LSCs). In addition, we presented an overview of LSCs mitochondrial dysregulated mechanisms in terms of (1) increasing in oxidative phosphorylation program (OXPHOS), as a crucial process for survival and self-renewal of LSCs,(2) low levels of reactive oxygen species (ROS), and (3) aberrant expression of B-cell lymphoma 2 (Bcl-2) with sustained mitophagy. Furthermore, these peculiarities may represent attractive new “hot spots” for mitochondrial-targeted therapy. Finally, we remark the potential of the LCS metabolic effectors to be exploited as novel therapeutic targets.

show abstract

“…In particular, the oxidized functional groups generated due to degradation make the polymer surface hydrophilic, and simultaneously cause coordination bonds with metals. Additionally, Krehula et al demonstrated that polyethylene could be decomposed under outdoor climate conditions to form carbonyl and vinyl groups, as shown in Figure 9a [69]. Therefore, as shown in Figure 9b,c, degradation of LDPE occurs, which may promote interaction between metal components and LDPE (coordination bonding and electrostatic attraction, etc.)…”

Section: R Review 11 Of 18mentioning

confidence: 99%

Automated SEM-EDS Analysis of Transition Metals and Other Metallic Compounds Emitted from Incinerating Agricultural Waste Plastic Film

Kim

Choi

Yoon³

et al. 2022

Atmosphere

View full text Add to dashboard Cite

Illegal open burning, which is criticized as a leading source of air pollutants among agricultural activities, currently requires constant effort and attention from countries around the world. A speciation analysis method is required to examine the harmful effects of particulate matter generated by incineration on the human body. In this study, to simulate open-air incineration, infrastructure for incineration tests complying with US EPA method 5G was built, and a large-area analysis was conducted on the particulate matter through automated SEM-EDS. For test specimens, waste mulching LDPE collected by Korea Environment Corporation Dangjin Office was used. To raise the identifiability of analyzed particles, the specimen was sampled on a plate made of Ag, which has a high atomic number, three times. Metal particulate matter showed a high reaction to C and C-O. The ratio of metal particulate matters that reacted to C and C-O was in the order of Cu (94.1%) > Fe (83.3%) > Al (79.7%). In this study, it was verified that waste mulching adsorbs metal chemicals originating from the soil due to its properties and deterioration, and that when it is incinerated, it emits particulate matter containing transition metals and other metals that contribute to excessive ROS production and reduction.

show abstract

Modulation of Reactive Oxygen Species in Health and Disease

Abstract: In diverse living organisms, signaling within the cell, chemical communication between cells or simply the fate of cells to survive or die is largely dependent on the intricate balance of control mechanisms related to reactive oxygen species (ROS)[...]

Cited by 39 publications

References 26 publications

Analysis of Chemical Compounds of Gaseous and Particulate Pollutants from the Open Burning of Agricultural HDPE Film Waste

Analysis of Chemical Compounds of Gaseous and Particulate Pollutants from the Open Burning of Agricultural HDPE Film Waste

Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe

Automated SEM-EDS Analysis of Transition Metals and Other Metallic Compounds Emitted from Incinerating Agricultural Waste Plastic Film

Contact Info

Product

Resources

About