Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

Костенко, Виталий Александрович; Akimov, O. Ye.; Gutnik, Oleksandr; Kostenko, Heorhii; Kostenko, V.O.; Romantseva, Tamara; Morhun, Yevhen; Назаренко, С. М.; Taran, Olena

doi:10.1016/j.heliyon.2023.e15551

Cited by 37 publications

(14 citation statements)

References 212 publications

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“…The immunomodulatory properties of quercetin are also combined with its anti-inflammatory effects, as evidenced by the modulation of several pro-inflammatory and anti-inflammatory cytokines, including IL-1β, IL-33, IL-10, IL-17, TNF-α, IL-6. HIF signalling increases the reactivity of reactive oxygen species formation, which may be the exact mechanism of the increased SAR production observed in our study [9]. Increased HIF signalling may also explain the atypical precapillary spiralling ob-served in our study, as the HIF pathway also increases the production of vascular endothelial growth factor (VEGF) [9].…”

Section: морфологія / Morphologymentioning

confidence: 51%

The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

Stetsuk,

Shepitko,

Zaporozhets

et al. 2024

VPBM

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Connection of the publication with planned research works.The study is a fragment of the research project "Experimental and morphological study of the effect of dipherelin, ethanol and 1% methacrylic acid, cryopreserved placental transplants on the morphological and functional state of a number of internal organs", state registration number 0119U102925.Introduction.In 1976, Stanlid reported that some phenolic compounds, including quercetin-3-O-rhamnoside (Q3R, also known as quercetin) and dihydroquercetin, may be involved in polar auxin transport in plants. Quercetin is thought to act as a natural phytotrophin involved in the transport of polar auxin, according to Bruun et al. (1992). On the other hand, wounding during rupture can trigger the production of quercetin-3-D-galactoside (known as hyperoside, Q3DG), which indirectly induces a rooting response (Osterc et al., 2007a). Zohra et al. (2011), [1]. working with grape cuttings, observed that quercetin synthesis coincided with rhizogenesis and suggested a direct role of this compound in grapes. Quercetin (rutin aglycone) and rutin are two flavonols that have been extensively studied in several models of intestinal inflammation. There are a large number of clinical trials evaluating the effects of quercetin on diseases, mainly as a product to reduce uric acid levels, improve neuromuscular function and neuroprotection, reduce the effects of inflammatory factors in myocardial infarction, chronic obstructive pulmonary disease, and Covid-19. On the other hand, quercetin has several effects in experimental models of intestinal inflammation and in vitro studies. Quercetin acts as an important antioxidant compound that reduces MPO activity, reduces colonic oxidative stress in acetic acid, trinitrobenzene sulfonic acid models, and counteracts inflammationinduced glutathione depletion. In addition, quercetin acted by modulating the intestinal microbiota, restoring the integrity of the colon epithelium and creating other protective effects [2]. Similar effects have also been observed with rutin in several preclinical studies.

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Section: морфологія / Morphologymentioning

confidence: 51%

The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

Stetsuk,

Shepitko,

Zaporozhets

et al. 2024

VPBM

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“…3 ). This inhibition leads to a reduction in oxidative-nitrosative stress in various organs, as indicated by research findings [ [80] , [81] , [82] , [83] , [84] ]. The activation of NF-κB is responsible for the upregulation of a number of genes encoding pro-oxidant and pro-inflammatory proteins, such as gp91 phox, xanthine oxidoreductase, cyclooxygenase 2, lipoxygenase 5 and 12, monooxygenases Cyp7b, Cyp2E1, Cyp2C11, inducible and neuronal isoforms of NO synthase, histolytic enzymes such as collagenase, stromelysin, gelatinase B, among others [ 85 , 86 ].…”

Section: Antioxidant Anti-inflammatory and Anti-diabetic Effectsmentioning

confidence: 93%

Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy

Opryshko,

Prokhach,

Akimov

et al. 2024

Heliyon

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“…Також ці речовини мають антиоксидантні властивості, допомагають організму захиститися від агресії вільних радикалів, пов'язуючи та нейтралізуючи ці нестабільні молекули [18]. Проведені дослідження показують, що агресивний вплив вільних радикалів корелюється з розвитком низки хронічних захворювань, серед яких цукровий діабет, рак та серцево-судинні патології [9,14,15]. Вчені провели серію експериментів на щурах та свинях і довели, що основний розподіл кверцетину відбувається у легенях, товстій кишці, нирках та печінці, натомість в тканинах мозку виявляються нижчі рівні метаболітів цієї речовини.…”

Section: вступunclassified

“…Вчені провели серію експериментів на щурах та свинях і довели, що основний розподіл кверцетину відбувається у легенях, товстій кишці, нирках та печінці, натомість в тканинах мозку виявляються нижчі рівні метаболітів цієї речовини. При надходженні цього флавоноїда лише з продуктами харчування, то в плазмі він виявляється у наномолярному діапазоні, водночас прийом добавок у вигляді аглікону або глікозидів дозволяє підвищити концентрацію до низького мікромолярного діапазо-ну [14]. Субстратом для синтезу NO є флавоноїд кверцетин, що має здатність зменшувати активацію та адгезію лейкоцитів і тромбоцитів до ендотелію судин, пригнічувати синтез протеїнів адгезії VCAM-1 та MCP-1, таким чином, запобігати утворенню й розвитку атеросклеротичних бляшок та мікротромбів.…”

Section: вступunclassified

The Influence of Quercetin on the Production of Reactive Oxygen-Nitrogen Forms in the Structure of the Interstitial Space of Rat Testicles With Long-Term Effect of Triptorelin

Stetsuk,

Shepitko,

Zaporozhets

et al. 2024

Act. Probl. of the Modern Med.

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Quercetin is a flavonoid commonly found in fruits, vegetables, and seeds. Flavonoids can help prevent cardiovascular diseases, reduce the risk of degenerative brain processes and cancer. Studies have shown that blocking the synthesis of luteinising hormone can lead to oxidative stress in the liver, heart, and salivary glands of rats. The purpose of this study was to assess alterations in the interstitial space of rat testes, identify sources of nitric oxide production, and measure the intensity of oxidative stress in the testes during long-term experimental central blocking of luteinising hormone synthesis by tryptorelin. The study was conducted on 15 sexually mature male white rats. The animals were divided into two groups. The first group (control) received a subcutaneous injection of 0.9% sodium chloride solution. The second group (experimental) received a subcutaneous injection of tryptorelin at a dose of 0.3 mg/kg of active ingredient for 365 days, with simultaneous addition of quercetin to the diet, which was administered orally through a gastric tube three times a day. Total nitric oxide production was assessed by measuring the activity of total NO synthase (gNOS). The activity of gNOS was determined by the increase in nitrite (NO2-) after incubation in Tris-buffered saline. The nitrite concentration was determined using the Gris-Ilosvay reagent at a wavelength of 540 nm. The activity of the inducible (iNOS) and constitutive (cNOS) isoforms was also determined using a selective iNOS inhibitor, aminoguanidine hydrochloride. The production of superoxide anion radical (O2--) was measured by the increase in the formation of diformazan resulting from the reaction of O2-- with nitroblue tetrazolium after incubation in a buffered solution containing sodium hydroxide. The administration of quercetin mitigates the adverse effects of tryptorelin on the structural and functional components of the connective tissue in the rat testes. This effect is observed on day 365 and is characterised by fibrosis and impaired nitric oxide production by constitutive isoforms of NO synthase.

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Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

Cited by 37 publications

References 212 publications

The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy

The Influence of Quercetin on the Production of Reactive Oxygen-Nitrogen Forms in the Structure of the Interstitial Space of Rat Testicles With Long-Term Effect of Triptorelin

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