2005
DOI: 10.1007/s11745-005-1463-4
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Modulation of respiratory syncytial virus‐induced prostaglandin E2 production by n−3 long‐chain polyunsaturated fatty acids in human respiratory epithelium

Abstract: Infection with respiratory syncytial virus (RSV) results in substantial infant morbidity and has been associated with the subsequent development of childhood asthma. Inflammatory mediators produced by both the epithelium and tissue leukocytes during RSV infection stimulate the release of chemotactic factors by the respiratory epithelium and the subsequent influx of inflammatory cells, predominantly neutrophils. We investigated the production of inflammatory mediators [prostaglandin E2 (PGE2), interleukin (IL)-… Show more

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Cited by 19 publications
(22 citation statements)
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“…The degree to which each of the FFA, excluding CLA, was incorporated into the A549 cells has been reported previously (11,12). As with all other FFA used in this project, each CLA isomer was readily incorporated dose-dependently into the cell membranes of the A549 respiratory epithelial cells.…”
Section: Production Of Cytokines and Pge 2 In Response To Stimulationmentioning
confidence: 60%
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“…The degree to which each of the FFA, excluding CLA, was incorporated into the A549 cells has been reported previously (11,12). As with all other FFA used in this project, each CLA isomer was readily incorporated dose-dependently into the cell membranes of the A549 respiratory epithelial cells.…”
Section: Production Of Cytokines and Pge 2 In Response To Stimulationmentioning
confidence: 60%
“…Each of the CLA isomers was incorporated proportionally to the content of the FFA mixture, resulting in a majority of 9-cis,11-trans CLA (~45%) and 10-trans,12-cis CLA (~35%) with the remaining isomers making up the final 20% of the total CLA increase. The incorporation of each of the FA-ALA, LA, OA, EPA, AA, DHA, and CLA-into the membranes of A549 cells at maximum incorporation (50 µg/mL FFA; 20-25% total phospholipids) (11,12) resulted in a significant decrease in the production of IL-8 when compared with approximately 50% maximum incorporation (10 µg/mL FFA) (Fig. 3B).…”
Section: Production Of Cytokines and Pge 2 In Response To Stimulationmentioning
confidence: 95%
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