Modulation of responses to visual stimulus onset and offset by chronic alcohol consumption and withdrawal in the rat visual cortex and lateral geniculate nucleus

Dulinskas, Redas; Rukšėnas, Osvaldas

doi:10.1016/j.alcohol.2019.12.002

Cited by 1 publication

(1 citation statement)

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“…In an auditory Go/No-Go task, Barry et al (2007) found that a single oral dose of caffeine (250 mg) resulted in focal rather than global increases in P1, P2, and P3b amplitudes to Go stimuli with no changes in latency, suggesting that caffeine differentially improves aspects of processing related to response production and task performance (Barry et al, 2007). Within the visual Go/NoGo paradigm, ERP studies have suggested that the N2 component reflects stimulus perception (Dulinskas and Ruksenas, 2019;Song et al, 2019), cognitive control, and response inhibition (Magnuson et al, 2019;Quaglia et al, 2019). P300 is the largest positive-going peak amplitude of the waveform within a time window of 300-400 ms and is considered to represent the allocation of attentional resources to rare salient stimuli (Cote et al, 2001;Marhöfer et al, 2015).…”

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confidence: 99%

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Chen

Zhang

Yang

et al. 2020

Front. Behav. Neurosci.

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Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD. Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design. Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD. Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual's arousal level and accelerated response-related decisions, while subjects' higher-level recognition had limited improvement with prolonged awareness.

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