Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanidin derivatives

Virmaux, N.; Bizec, Jean-Claude; Nullans, Gérard; Ehret, Sylviane; Mandel, P.

doi:10.1042/bst0180686

Cited by 9 publications

(9 citation statements)

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“…Effect of Anthocyanins on PDE Activity. In previous publications, the effects of anthocyanins on ROS PDE were controversial ( , ). Therefore, first we examined the effect of the four purified black currant anthocyanins on PDE.…”

Section: Resultsmentioning

confidence: 99%

Stimulatory Effect of Cyanidin 3-Glycosides on the Regeneration of Rhodopsin

Matsumoto

Nakamura

Tachibanaki

et al. 2003

J. Agric. Food Chem.

197

148

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Anthocyanins have been suggested to improve visual functions. This study examined the effect of four anthocyanins in black currant fruits on the regeneration of rhodopsin using frog rod outer segment (ROS) membranes. Cyanidin 3-glycosides, glucoside and rutinoside, stimulated the regeneration, but the corresponding delphinidins showed no significant effect. The formation of a regeneration intermediate was suggested to be accelerated by cyanidin 3-rutinoside. Their effects on the cGMP-phosphodiesterase activity in the ROS membranes were also investigated but found to be negligible. It was concluded that the major effect of anthocyanins in rod photoreceptors is on the regeneration of rhodopsin.

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Section: Resultsmentioning

confidence: 99%

Stimulatory Effect of Cyanidin 3-Glycosides on the Regeneration of Rhodopsin

Matsumoto

Nakamura

Tachibanaki

et al. 2003

J. Agric. Food Chem.

197

148

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“…Several studies document a potential role for flavonoids to improve retinal photoreceptor sensitivity in vitro by affecting the rate of rhodopsin regeneration ( 166 , 175 – 177 ), or by modulating the inhibition of downstream G proteins involved in the phototransduction cascade ( 178 , 179 ), or by downregulating retinoid-binding proteins ( 163 ). In an in vitro bovine ciliary muscle preparation, anthocyanins interacted with the endothelin-1 pathway to reduce muscle contractility, which relates to accommodative processes for distance vision in myopic eyes ( 180 ).…”

Section: Blueberries and Anthocyanins In Vision And Eye Healthmentioning

confidence: 99%

Recent Research on the Health Benefits of Blueberries and Their Anthocyanins

Kalt

Cassidy

Howard

et al. 2020

Advances in Nutrition

395

208

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Awareness of the human health benefits of blueberries is underpinned by a growing body of positive scientific evidence from human observational and clinical research, plus mechanistic research using animal and in vitro models. Blueberries contain a large number of phytochemicals, including abundant anthocyanin pigments. Of their various phytochemicals, anthocyanins probably make the greatest impact on blueberry health functionality. Epidemiological studies associate regular, moderate intake of blueberries and/or anthocyanins with reduced risk of cardiovascular disease, death, and type 2 diabetes, and with improved weight maintenance and neuroprotection. These findings are supported by biomarker-based evidence from human clinical studies. Among the more important healthful aspects of blueberries are their anti-inflammatory and antioxidant actions and their beneficial effects on vascular and glucoregulatory function. Blueberry phytochemicals may affect gastrointestinal microflora and contribute to host health. These aspects have implications in degenerative diseases and conditions as well as the aging process. More evidence, and particularly human clinical evidence, is needed to better understand the potential for anthocyanin-rich blueberries to benefit public health. However, it is widely agreed that the regular consumption of tasty, ripe blueberries can be unconditionally recommended.

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“…In ophthalmology, the antioxidant effects of anthocyanins have been demonstrated on retinal pigment epithelium (Milbury and others ). Indeed, bilberry anthocyanins improve night vision through interaction with rhodopsin (Bastide and others ) or phosphodiesterase (PDE) on phototransduction (Ferretti and others ; Virmaux and others ). Inhibition of PDE (human PDE5A1) by grape anthocyanins has been observed in vitro as one of the mechanisms inducing smooth muscle cells vasorelaxation (Dell'Agli and others ).…”

Section: Biological Activitymentioning

confidence: 99%

The Case for Anthocyanin Consumption to Promote Human Health: A Review

Pojer

Mattivi

Johnson

et al. 2013

Comp Rev Food Sci Food Safe

557

364

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Anthocyanins belong to the flavonoid group of polyphenolic compounds, which are responsible for the red and blue colors of plant organs such as fruits, flowers, and leaves. Due to their frequent presence in plants, particularly berry fruits, vegetables, and grapes, they are key components of the human diet. Interest in anthocyanins has increased widely during the past decade. Numerous studies have suggested that anthocyanins have a wide range of health-promoting properties. These compounds are therefore considered to be a functional food factor, which may have important implications in the prevention of chronic diseases. The aim of this body of work is to investigate and review the current literature on anthocyanins, and particularly their pharmacokinetics and any health-promoting properties, in order to summarize existing knowledge and highlight any aspects that require further study and analysis.

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Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanidin derivatives

Cited by 9 publications

References 0 publications

Stimulatory Effect of Cyanidin 3-Glycosides on the Regeneration of Rhodopsin

Stimulatory Effect of Cyanidin 3-Glycosides on the Regeneration of Rhodopsin

Recent Research on the Health Benefits of Blueberries and Their Anthocyanins

The Case for Anthocyanin Consumption to Promote Human Health: A Review

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