Modulation of serum gastric parietal cell antibody level by levamisole and vitamin B12 in oral lichen planus

Lin, Hung-Pin; Wang, Yi Ping; Js, Chia; Chiang, Chun-Pin; Sun, Aihua

doi:10.1111/j.1601-0825.2010.01711.x

Cited by 20 publications

(14 citation statements)

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“…Even the patients possess one or more of these contributing factors, the development of PA may still need a long period of years (Toh et al , ; Lahner and Annibale, ). Our previous study found that for GPCA‐positive oral lichen planus patients, treatment modality containing intramuscular injection of vitamin B12 can effectively reduce the high serum GPCA level to undetectable level (Lin et al , ). This finding indicates that intramuscular administration of sufficient vitamin B12 not only can reverse the patients' GPCA status from positive to negative but also can be an effective treatment modality for PA because vitamin B12 can be absorbed directly to blood stream but not through the intrinsic factor‐mediated pathway.…”

Section: Discussionmentioning

confidence: 99%

Do all the patients with gastric parietal cell antibodies have pernicious anemia?

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Do all the patients with gastric parietal cell antibodies have pernicious anemia?

et al. 2012

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“…Based on our findings, hematological screening for hematinic deficiencies should be included in routine laboratory examination of OLP patients. Several studies have proposed that vitamin replacement may improve the general health of OLP patients and increase their healing ability [12,36]. Therefore, compensation of hematinic deficiencies with adequate nutritional supplements or in combination with other drugs, is supposed to produce improved therapeutic effects on OLP patients [12,36].…”

Section: Discussionmentioning

confidence: 99%

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

et al. 2020

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Background Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, and its causative factors and pathogenesis are not fully understood. Existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP. Methods A total of 236 OLP patients and 226 age-and-gender-matched healthy controls were enrolled in this study. The levels of hemoglobin (Hb), serum folate, vitamin B12 and ferritin were measured and compared between OLP patients and healthy controls. An REU (reticular/hyperkeratotic, erosive/erythematous, ulcerative) scoring system was adopted and compared between the OLP patients with and without hematinic deficiencies. The correlation between hematinic deficiencies and OLP was analyzed. Results The frequencies of serum ferritin and vitamin B12 deficiency in OLP patients were both significantly higher than those of the healthy controls. According to gender and age, the profiles of hematinic deficiencies in OLP patients were significantly different. As for the REU score, no significant difference existed between OLP patients with and without hematinic deficiencies. Both serum ferritin deficiency and serum vitamin B12 deficiency were significantly correlated with OLP. Conclusions The present study suggested a significant association between hematinic deficiencies and OLP. Iron, folate, and vitamin B12 levels in OLP patients should be monitored routinely. Further studies are warranted to explore the interactions between OLP and hematinic deficiencies.

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“…Our findings of the present study highly suggested that the hematological screening for hematinic deficiencies should be included in routine laboratory examination of OLP patients. Several studies have proposed that vitamin replacement may improve the general health state of OLP patients and increase their healing ability [6,24]. Therefore, compensation of hematinic deficiencies with adequate nutritional supplements, or in combination with other drugs, is supposed to produce improved therapeutic effects on OLP patients [6,24].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have proposed that vitamin replacement may improve the general health state of OLP patients and increase their healing ability [6,24]. Therefore, compensation of hematinic deficiencies with adequate nutritional supplements, or in combination with other drugs, is supposed to produce improved therapeutic effects on OLP patients [6,24]. In addition, dietary assessment and guidance to maintain adequate nutrition and optimal quality of life should be considered as a component of OLP management [16].…”

Section: Discussionmentioning

confidence: 99%

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

Bao

Yang

Shi

et al. 2020

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Background Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, its causative factors and pathogenesis still remain obscure. The existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP patients and evaluate the correlation between hematinic deficiencies and OLP. Methods 236 OLP patients and 226 age-and gender-matched healthy controls were enrolled in this study. The levels of hemoglobin (Hb), serum folate, vitamin B12 and ferritin were measured and compared between OLP patients and healthy controls. REU (reticular/hyperkeratotic, erosive/erythematous, ulcerative) scoring system was adopted and compared between the OLP patients with and without hematinic deficiencies. The correlation between hematinic deficiencies and OLP was analyzed. Results The frequencies of serum ferritin and vitamin B12 deficiency in OLP patients were both significantly higher than those of the healthy controls. According to gender and age, the profiles of hematinic deficiencies in OLP patients were significantly different. As for REU score, no significant difference existed between OLP patients with and without hematinic deficiencies. Both serum ferritin deficiency and serum vitamin B12 deficiency were significantly correlated with OLP. Conclusions The present study suggested a significant association between hematinic deficiencies and OLP. Iron, folate, and vitamin B12 levels in OLP patients should be monitored routinely. In the case of hematinic deficiencies, appropriate supplementation therapy is necessary. Further studies are warranted to explore the interactions between OLP and hematinic deficiencies.

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Modulation of serum gastric parietal cell antibody level by levamisole and vitamin B12 in oral lichen planus

Abstract: For GPCA-positive OLP patients, treatment modality containing vitamin B12 can effectively reduce the high serum GPCA level to undetectable level. OLP patients with underlying autoimmune atrophic gastritis trait should receive a maintenance vitamin B12 treatment for life.

Cited by 20 publications

References 15 publications

Do all the patients with gastric parietal cell antibodies have pernicious anemia?

Do all the patients with gastric parietal cell antibodies have pernicious anemia?

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study

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