Modulation of social behavior and dominance status by chronic pain in mice

Tansley, Shannon; Tuttle, Alexander H.; Wu, Neil; Tohyama, Sarasa; Dossett, Kimberly; Gerstein, Lindsay; Ham, Boram; Austin, Jean-Sébastien; Sotocinal, Susana G.; Mogil, Jeffrey S.

doi:10.1111/gbb.12514

Cited by 24 publications

(16 citation statements)

References 22 publications

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“…On the other hand, dominance relationships can be altered by chronic pain. It has been reported that chronic constriction injury in rats and SNI in mice leads to loss of dominance in the different dominance experiment (Monassi et al, 2003; Tansley et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the effect of the pain on social factors seems to be more related to the duration of pain before testing. It has been shown that short‐lasting pain did not significantly affect propinquity behavior on the tube co‐occupancy test, but long‐lasting pain produced a significant change in the propinquity behavior in mice (Tansley et al, 2019). Also, Palazzo et al (2016) reported that 1 month after spared nerve injury (SNI) in mice, the animals in pain exhibited impairment in both their sociability as well as social novelty preference in the three‐chambered test.…”

Section: Discussionmentioning

confidence: 99%

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Pain‐induced aggression and changes in social behavior in mice

Khosravi

Khalilzadeh

Saiah

2020

Aggressive Behavior

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The effects of neuropathic, formalin, and acetic acid‐induced visceral pain were investigated on the social and aggressive behaviors in the Swiss male mice. Neuropathic pain was induced by tibial nerve transection (TNT). Also, somatic and visceral pain was conducted by intraplantar injection of diluted formalin (1%, 20 μl) and intraperitoneal administration of acetic acid (0.6%, 200 μl), respectively. Fourteen and twenty one days after the TNT surgery, and also, 1 and 7 days following formalin and acetic acid administration, the three‐chambered test was used to determine sociability and preference for social novelty and resident/intruder test was used for the evaluation of the aggressive behaviors. In the sociability phase of the three‐chambered test, all the three models of pain did not change the animal's sociability. However, in the social novelty preference phase, the animals in pain showed deficits in social novelty preference by a significant increase in the time spent with the familiar mice compared to the control groups. Also, animals in pain significantly showed more aggressive behaviors like biting and clinching and have much less attack latency in comparison to the control groups. Pain‐induced changes in the social novelty preference and aggressive behaviors continued in the neuropathic group until the end of the experiment. However, 7 days following the induction of both formalin and visceral pain, animals' social memory, and aggression almost returned to the standard value. These results suggest that long‐lasting pain could lead to social memory impairment and increase aggressive behaviors in mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pain‐induced aggression and changes in social behavior in mice

Khosravi

Khalilzadeh

Saiah

2020

Aggressive Behavior

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“…Six female mice 8 to 12 weeks old were used for the experiment (3 for SNI group, 3 for Sham group). We performed the experiments on female mice because female mice are less aggressive to other female mice than male mice [ 76 ]. We considered this stress as a confounder in our experiments that might alters the gut microbial diversity and composition.…”

Section: Methodsmentioning

confidence: 99%

A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model

et al. 2020

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Background Neuropathic pain is an abnormally increased sensitivity to pain, especially from mechanical or thermal stimuli. To date, the current pharmacological treatments for neuropathic pain are still unsatisfactory. The gut microbiota reportedly plays important roles in inducing neuropathic pain, so probiotics have also been used to treat it. However, the underlying questions around the interactions in and stability of the gut microbiota in a spared nerve injury-induced neuropathic pain model and the key microbes (i.e., the microbes that play critical roles) involved have not been answered. We collected 66 fecal samples over 2 weeks (three mice and 11 time points in spared nerve injury-induced neuropathic pain and Sham groups). The 16S rRNA gene was polymerase chain reaction amplified, sequenced on a MiSeq platform, and analyzed using a MOTHUR- UPARSE pipeline. Results Here we show that spared nerve injury-induced neuropathic pain alters gut microbial diversity in mice. We successfully constructed reliable microbial interaction networks using the Metagenomic Microbial Interaction Simulator (MetaMIS) and analyzed these networks based on 177,147 simulations. Interestingly, at a higher resolution, our results showed that spared nerve injury-induced neuropathic pain altered both the stability of the microbial community and the key microbes in a gut micro-ecosystem. Oscillospira, which was classified as a low-abundance and core microbe, was identified as the key microbe in the Sham group, whereas Staphylococcus, classified as a rare and non-core microbe, was identified as the key microbe in the spared nerve injury-induced neuropathic pain group. Conclusions In summary, our results provide novel experimental evidence that spared nerve injury-induced neuropathic pain reshapes gut microbial diversity, and alters the stability and key microbes in the gut.

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“…Six female mice 8 to 12 weeks old were used for the experiment (3 for SNI group, 3 for Sham group). We performed the experiments on female mice because female mice are less aggressive to other female mice than male mice (Tansley et al, 2019). We considered this stress as a confounder in our experiments that might alters the gut microbial diversity and composition.…”

Section: Animal Preparationmentioning

confidence: 99%

A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model

Brandon-Mong

Shaw

Chen

et al. 2020

Preprint

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Background: Neuropathic pain is an abnormally increased sensitivity to pain, especially from mechanical or thermal stimuli. To date, the current pharmacological treatments for neuropathic pain are still unsatisfactory. The gut microbiota reportedly plays important roles in inducing neuropathic pain, so probiotics have also been used to treat it. However, the underlying questions around the interactions in and stability of the gut microbiota in a spared nerve injury-induced neuropathic pain model and the key microbes (i.e., the microbes that play critical roles) involved have not been answered. We collected 66 fecal samples over two weeks (three mice and 11 time points in spared nerve injury-induced neuropathic pain and Sham groups). The 16S rRNA gene was polymerase chain reaction amplified, sequenced on a MiSeq platform, and analyzed using a MOTHUR- UPARSE pipeline.Results: Here we show that spared nerve injury-induced neuropathic pain alters gut microbial diversity in mice. We successfully constructed reliable microbial interaction networks using the Metagenomic Microbial Interaction Simulator (MetaMIS) and analyzed these networks based on 177,147 simulations. Interestingly, at a higher resolution, our results showed that spared nerve injury-induced neuropathic pain altered both the stability of the microbial community and the key microbes in a gut micro-ecosystem. Oscillospira, which was classified as a low-abundance and core microbe, was identified as the key microbe in the Sham group, whereas Staphylococcus, classified as a rare and non-core microbe, was identified as the key microbe in the spared nerve injury-induced neuropathic pain group. Conclusions: In summary, our results provide novel experimental evidence that spared nerve injury-induced neuropathic pain reshapes gut microbial diversity, and alters the stability and key microbes in the gut.

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Modulation of social behavior and dominance status by chronic pain in mice

Cited by 24 publications

References 22 publications

Pain‐induced aggression and changes in social behavior in mice

Pain‐induced aggression and changes in social behavior in mice

A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model

A network approach to investigating the key microbes and stability of gut microbial communities in a mouse neuropathic pain model

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