2018
DOI: 10.3389/fncom.2018.00049
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Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models

Abstract: In spike-timing dependent plasticity (STDP) change in synaptic strength depends on the timing of pre- vs. postsynaptic spiking activity. Since STDP is in compliance with Hebb’s postulate, it is considered one of the major mechanisms of memory storage and recall. STDP comprises a system of two coincidence detectors with N-methyl-D-aspartate receptor (NMDAR) activation often posited as one of the main components. Numerous studies have unveiled a third component of this coincidence detection system, namely neurom… Show more

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Cited by 51 publications
(52 citation statements)
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References 169 publications
(353 reference statements)
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“…The action of different neuromodulators provide a way of modulating the STDP or synaptic transmission 427 functions, and studying the effects of diverse neuromodulatory states on the plasticity of connections in many 428 brain regions is possible with recent advances in experimental techniques [84][85][86]. For instance, timing prop-429 erties of STDP have been shown to depend on the dynamics of the latent signaling pathways involving these 430 factors.…”
mentioning
confidence: 99%
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“…The action of different neuromodulators provide a way of modulating the STDP or synaptic transmission 427 functions, and studying the effects of diverse neuromodulatory states on the plasticity of connections in many 428 brain regions is possible with recent advances in experimental techniques [84][85][86]. For instance, timing prop-429 erties of STDP have been shown to depend on the dynamics of the latent signaling pathways involving these 430 factors.…”
mentioning
confidence: 99%
“…ity [81], or the location of synaptic inputs on the dendritic tree [82]. However, recent experimental studies 225 have highlighted an important role of neuromodulators in regulating plasticity across the brain [83][84][85][86], as 226 they convey information about novelty or reward. Indeed, neuromodulators such as dopamine, acetylcholine 227 and noradrenaline, but also brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA),…”
mentioning
confidence: 99%
“…Thus, failure to correctly position synapses in development has severe and mostly irreversible consequences during later life (57) and could play a role in neuropsychiatric disorders (11) . However, the minimal model derived from the neurotrophin model is sufficiently general to also be implemented in the adult, where the functional roles of MMP9 and calcium could equivalently be filled by postsynaptic depolarization, NMDA receptor activation, endocannabinoid or nitric oxide signaling or by more complex diffusible plasticity-related products (58) . Thus, our predictions regarding the organization of synapses are not contingent on a specific biophysical implementation of our minimal model as long as it has the three ingredients: distance-and correlationdependent competition and structural plasticity.…”
Section: Discussionmentioning
confidence: 99%
“…Synaptic plasticity is tightly controlled by various neuromodulators, also called the third factor (Foncelle et al, 2018), among which, BDNF appears to be indispensable for striatal functions (Baydyuk et al, 2011;Besusso et al, 2013;Unterwald et al, 2013). Indeed, in addition to its prominent role in inducing neuronal proliferation and differentiation, migration and survival, BDNF is a key regulator of synaptic transmission and plasticity in the adult brain (Carvalho et al, 2008;Waterhouse and Xu, 2009;Edelmann et al, 2014;Park et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Upon various activity-dependent patterns (rate-or spike-timing-coded), corticostriatal synapses exhibit bidirectional plasticity, LTP and LTD, mediated by NMDA and type-1 cannabinoid receptors (CB1Rs), respectively (Di Filippo et al, 2009;Lovinger, 2010). Thus, identifying factors modulating the expression of activity-dependent plasticity (Foncelle et al, 2018) in the striatum is of crucial importance.…”
Section: Introductionmentioning
confidence: 99%