Modulation of thalamic auditory neurons by the primary auditory cortex

Tang, Jie; Yang, Weiguo; Suga, Nobuo

doi:10.1152/jn.00251.2012

Cited by 24 publications

(14 citation statements)

References 46 publications

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“…Another intriguing possibility is that changes may occur initially in the AC and are then transmitted to the IC via descending projections (Figure 1 ). There is extensive evidence to suggest that descending corticofugal projections are not only involved in short-term modulation of auditory processing but long-term changes as well, and have specifically been implicated in gain control ( 80 – 83 ). Indeed, inactivation of the AC has been shown to modulate firing rates and rate-level functions in the IC in a complex manner ( 75 ).…”

Section: Gain Enhancement In the Central Auditory Systemmentioning

confidence: 99%

Central Gain Control in Tinnitus and Hyperacusis

2014

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Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of sensory input is referred to as central gain enhancement. Enhanced central gain is hypothesized to be a potential mechanism that gives rise to hyperacusis and tinnitus, two debilitating auditory perceptual disorders that afflict millions of individuals. This review will examine the evidence for gain enhancement in the central auditory system in response to cochlear damage. Further, it will address the potential cellular and molecular mechanisms underlying this enhancement and discuss the contribution of central gain enhancement to tinnitus and hyperacusis. Current evidence suggests that multiple mechanisms with distinct temporal and spectral profiles are likely to contribute to central gain enhancement. Dissecting the contributions of these different mechanisms at different levels of the central auditory system is essential for elucidating the role of central gain enhancement in tinnitus and hyperacusis and, most importantly, the development of novel treatments for these disorders.

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Section: Gain Enhancement In the Central Auditory Systemmentioning

confidence: 99%

Central Gain Control in Tinnitus and Hyperacusis

2014

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“…As in the midbrain, electrical stimulation studies have shown that corticofugal modulation can alter the receptive field properties of neurons in the auditory thalamus (Tang, Yang & Suga, ; Zhang & Suga, ). Furthermore, recent work has shown that the receptive fields of neurons in the visual sector of cat TRN (i.e., the perigeniculate nucleus) are comparable to those of LGN neurons (Soto‐Sánchez, Wang, Vaingankar, Sommer & Hirsch, ).…”

Section: Context‐dependent Modulation Of Thalamic Sensory Processingmentioning

confidence: 99%

Development, organization and plasticity of auditory circuits: Lessons from a cherished colleague

Lohse

Bajo

King

2018

Eur J of Neuroscience

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Ray Guillery was a neuroscientist known primarily for his ground-breaking studies on the development of the visual pathways and subsequently on the nature of thalamocortical processing loops. The legacy of his work, however, extends well beyond the visual system. Thanks to Ray Guillery's pioneering anatomical studies, the ferret has become a widely used animal model for investigating the development and plasticity of sensory processing. This includes our own work on the auditory system, where experiments in ferrets have revealed the role of sensory experience during development in shaping the neural circuits responsible for sound localization, as well as the capacity of the mature brain to adapt to changes in inputs resulting from hearing loss. Our research has also built on Ray Guillery's ideas about the possible functions of the massive descending projections that link sensory areas of the cerebral cortex to the thalamus and other subcortical targets, by demonstrating a role for corticothalamic feedback in the perception of complex sounds and for corticollicular projection neurons in learning to accommodate altered auditory spatial cues. Finally, his insights into the organization and functions of transthalamic corticocortical connections have inspired a raft of research, including by our own laboratory, which has attempted to identify how information flows through the thalamus.

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“…The implication for these intersecting feedforward and feedback circuits is that the output signal at any station will be the collective sum of the ascending activity along with the modifications from direct and polysynaptic links from above. Feedback circuits could sharpen frequency tuning curves (Yan et al, ; Tang et al, ), calibrate directional selectivity (Zhou and Jen, ; Nakamoto et al, ), modulate response features (Ma and Suga, ; Yan and Ehret, ), or unmask acoustic signals in a noisy background (Nieder and Nieder, ). A better understanding of the details of these descending projections will inform us of possible mechanisms of action.…”

mentioning

confidence: 99%

Descending projections from the inferior colliculus to the dorsal cochlear nucleus are excitatory

Milinkeviciute

Muniak

Ryugo

2016

J of Comparative Neurology

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Ascending projections of the dorsal cochlear nucleus (DCN) target primarily the contralateral inferior colliculus (IC). In turn, the IC sends bilateral descending projections back to the DCN. We sought to determine the nature of these descending axons in order to infer circuit mechanisms of signal processing at one of the earliest stages of the central auditory pathway. An anterograde tracer was injected in the IC of CBA/Ca mice to reveal terminal characteristics of the descending axons. Retrograde tracer deposits were made in the DCN of CBA/Ca and transgenic GAD67-EGFP mice to investigate the cells giving rise to these projections. A multiunit best frequency was determined for each injection site. Brains were processed by using standard histologic methods for visualization and examined by fluorescent, brightfield, and electron microscopy. Descending projections from the IC were inferred to be excitatory because the cell bodies of retrogradely labeled neurons did not colabel with EGFP expression in neurons of GAD67-EGFP mice. Furthermore, additional experiments yielded no glycinergic or cholinergic positive cells in the IC, and descending projections to the DCN were colabeled with antibodies against VGluT2, a glutamate transporter. Anterogradely labeled endings in the DCN formed asymmetric postsynaptic densities, a feature of excitatory neurotransmission. These descending projections to the DCN from the IC were topographic and suggest a feedback pathway that could underlie a frequency-specific enhancement of some acoustic signals and suppression of others. The involvement of this IC-DCN circuit is especially noteworthy when considering the gating of ascending signal streams for auditory processing. J. Comp. Neurol. 525:773-793, 2017. © 2016 Wiley Periodicals, Inc.

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Modulation of thalamic auditory neurons by the primary auditory cortex

Cited by 24 publications

References 46 publications

Central Gain Control in Tinnitus and Hyperacusis

Central Gain Control in Tinnitus and Hyperacusis

Development, organization and plasticity of auditory circuits: Lessons from a cherished colleague

Descending projections from the inferior colliculus to the dorsal cochlear nucleus are excitatory

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