Modulation of the cyclooxygenase pathway via inhibition of nitric oxide production contributes to the anti-inflammatory activity of kaempferol

Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells

“…Kaempferol is a common flavonoid in human diet and has various biological activities including antioxidant, anticancer, and anti-inflammatory effects (Kang et al 2008;Mahat et al 2010). A number of reports have shown the immunomodulatory effect of kaempferol on T lymphocytes (Okamoto et al 2002), B cells (Zunino and Storms 2009), macrophages (Comalada et al 2006;Hamalainen et al 2007;Harasstani et al 2010;Kim et al 2005;Liang et al 2001), neutrophils (Moreira et al 2007;Selloum et al 2001;Wang et al 2006), basophils (Shim et al 2009), and mast cells (Kempuraj et al 2005;Lee et al 2010).…”

“…Although there are insufficient data to provide conclusive evidence on the health effects of most flavonoids (Kay 2010), the in vivo effects of kaempferol have been shown in several animal models, such as allergic lung disease (Medeiros et al 2009), carrageenan induced rat air pouch model (Mahat et al 2010), thermal burn-induced skin injuries (Park et al 2010), and mouse model of osteosarcoma (Huang et al 2010b). These reports imply that kaempferol may have clinical application, especially the safety issue of kaempferol has been discussed (Lee et al 2009;Li et al 2008).…”

Evaluation of the in vitro Anti-inflammatory Activity of Nerium oleander L. Flower Extracts and Activity-Guided Isolation of the Active Constituents

“…The in vivo and in vitro anti-inflammatory activites of these three compounds were previously reported in several studies [53][54][55][56]. Chlorogenic acid was shown to decrease the levels of COX-2 and PGE2 and was also found to inhibit JNK, but not p38 and ERK (p44/42) phosphorylations on LPS induced Raw 264.7 macrophages [57].…”

Beneficial Health Effects of Bioactive Compounds Present in Spices and Aromatic Herbs

“…Mahat et al [107] investigate whether kaempferol modulates the cyclooxygenase pathway via inhibition of nitric oxide production, which in turn contributes to its anti-inflammatory activity. In other study Pang et al [108] informed that kaempferol at 5, 10, and 20µM inhibited the TNF-α-induced production of IL-6 in mouse osteoblasts in a dosedependent manner.…”