Modulation of the Direction and Magnitude of Hebbian Plasticity in Human Motor Cortex by Stimulus Intensity and Concurrent Inhibition

Cash, Robin; Jegatheeswaran, Gaayathiri; Ni, Zhen; Chen, R

doi:10.1016/j.brs.2016.08.007

Cited by 24 publications

(27 citation statements)

References 61 publications

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“…Activity of intracortical inhibitory circuits explored by SAI and SICI showed an inverse correlation with the magnitude of LTP that can be induced by PAS [20,21]. Thus, the results of this study apparently follow our previous evidences suggesting altered cortical plasticity in MS patients [15,16,23].…”

Section: Discussionsupporting

confidence: 80%

“…Indeed, the amplitude of LTP-like plasticity induced by transcranial magnetic stimulation (TMS) through the paired associative stimulation (PAS) protocol, varies depending on the individual level of inhibitory cortical circuits [15]. TMS studies revealed that weaker PAS-induced LTP correlated with stronger GABAergic activity in the primary motor cortex as measured by short-interval intracortical inhibition (SICI) [20] and with stronger inhibitory afferent projections over the primary motor cortex as measured by short-latency afferent inhibition (SAI) [21] in healthy individuals. These findings raised the hypothesis that PDGF's influence over PAS induced LTP may be mediated by SICI or SAI cortical circuits.…”

Section: Introductionmentioning

confidence: 99%

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PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis

Mango

Nisticò

Furlan³

et al. 2018

Neurochem Res

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Maintenance of synaptic plasticity reserve is crucial to contrast clinical deterioration in MS and PDGF plays a key role in this phenomenon. Indeed, higher cerebrospinal fluid PDGF concentration correlates with improved clinical recovery after a relapse, and the amplitude of LTP-like cortical plasticity in relapsing-remitting MS patients. However, LTP-like cortical plasticity varies depending on the individual level of inhibitory cortical circuits. Aim of this study was to explore whether PDGF-CSF concentration correlates with inhibitory cortical circuits explored by means of transcranial magnetic stimulation in patients affected by relapsing-remitting MS. We further performed electrophysiological experiments evaluating GABAergic transmission in the experimental autoimmune encephalomyelitis (EAE) hippocampus. Our results reveal that increased CSF PDGF concentration correlates with decreased short afferent inhibition in the motor cortex in MS patients and decreased GABAergic activity in EAE. These findings show that PDGF affects GABAergic activity both in MS patients and in EAE hippocampus.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis

Mango

Nisticò

Furlan³

et al. 2018

Neurochem Res

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“…This is partially supported by linear responses to increases in the intensity of conventional rTMS in healthy individuals (1 Hz [Nahas et al, ]) and in clinical populations (10 Hz [Padberg et al, ]). Studies using different modulatory paradigms have also shown a shift from LTD‐ to LTP‐like effects at higher intensity (Batsikadze, Moliadze, Paulus, Kuo, & Nitsche, ; Cash, Jegatheeswaran, Ni, & Chen, ; Doeltgen & Ridding, ), corroborating the idea of increased propensity for LTP‐like changes at higher intensity. However, systematic investigation of intensity‐dependent effects of iTBS in the prefrontal cortex has not been established.…”

Section: Introductionmentioning

confidence: 63%

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Chung

Rogasch

Hoy

et al. 2017

Human Brain Mapping

101

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Intermittent theta burst stimulation (iTBS) is a noninvasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex. Sixteen healthy participants received iTBS over prefrontal cortex at either 50, 75 or 100% resting motor threshold in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials and oscillations. The n-back task was used to assess changes in working memory performance. The data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS yielded the largest neurophysiological changes. Improvement in reaction time in the 3-back task was supported by the change in alpha power, however, comparison between conditions revealed no significant differences. The assumption that higher intensity results in greater neuromodulatory effects may be false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.

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“…However, due to ethical reasons, invasive methods were not permitted in human subjects. Although there are a few candidate methods capable of inducing LTP, such as direct electrical stimulation [9], sensory stimulation, and transcranial magnetic stimulation [10]. The sensory induced LTP is a non-invasive stimulating method that can be accurately elicited in the human sensory cortex and other functional cortices [11,12].…”

Section: Introductionmentioning

confidence: 99%

A method to induce human cortical long-term potentiation by acoustic stimulation

Lei

Zhao

et al. 2017

Acta Oto-Laryngologica

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Object: Acoustic stimulation induced LTP in the human auditory cortex was successfully recorded for the first time by electroencephalography (EEG) using a stimulus of 1 kHz pure-tone in 2005. However, it was barely reproduced, given considerable challenges to reliably elicit and accurately record the enhanced potentials in vivo. The purpose of this paper was to explore whether acoustic stimuli other than 1 kHz pure-tone could generate LTP or not. Measures: To answer this question, we proposed a tetanic-stimulation paradigm of pure-tones, narrow-band noises (NBNs) and white noise (WN) to elicit LTP in human subjects. Results:The results showed that pure-tones with different frequency could elicit LTP in human auditory cortex, and proved for the first time that NBNs and WN could also achieve the same goal. Interestingly, it was also shown that the noises with certain bandwidth induced the greatest LTP and the WN induced LTP had the least variation over time and across subjects in comparison with puretones and NBNs. Conclusions: In light of the results, we suggested to use the paradigm for broader studies of human in vivo cortical plasticity. ARTICLE HISTORY

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Modulation of the Direction and Magnitude of Hebbian Plasticity in Human Motor Cortex by Stimulus Intensity and Concurrent Inhibition

Cited by 24 publications

References 61 publications

PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis

PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

A method to induce human cortical long-term potentiation by acoustic stimulation

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