Modulation of the duration of human postprandial motor activity by sleep

Kumar, Devinder; Soffer, Edy E.; Wingate, David; Britto, JM; Dasgupta, Agnik; Mridha, Kakali

doi:10.1152/ajpgi.1989.256.5.g851

Cited by 20 publications

(25 citation statements)

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“…E1, antral electrode; E2 and E3, duodenal electrodes. variability in the MMC pattern, as previously reported in human studies (Kumar et al 1989). The obvious advantage of the present telemetry method over the wire method is the possibility of obtaining recordings from a freely moving animal in its own cage or recordings from a single animal in a group (litter).…”

Section: Discussionsupporting

confidence: 83%

Telemetry Facilitates Long‐Term Recording of Gastrointestinal Myoelectrical Activity in Pigs

Gacsalyi

Zabielski

Pierzynowski

2000

Experimental Physiology

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A method of telemetric measurement of antroduodenal myoelectrical activity (EMG) in freely moving pigs has been developed. Silver bipolar electrodes were sutured on the antrum and duodenum and connected to a telemetry transmitter implanted extraperitoneally between the abdominal muscles. The EMG signals were collected by a receiver, filtered, amplified and archived by a computer. The telemetric EMG signal did not differ from that obtained with a conventional wire method. Substantial differences between day and night migrating myoelectric complex (MMC) patterns were found. The advantages of telemetric EMG recording make it a useful tool for long‐term recording of antroduodenal EMG.

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Section: Discussionsupporting

confidence: 83%

Telemetry Facilitates Long‐Term Recording of Gastrointestinal Myoelectrical Activity in Pigs

Gacsalyi

Zabielski

Pierzynowski

2000

Experimental Physiology

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“…An absence of MMC during 24-hour period is considered abnormal 30,40. Prolonged ambulatory antroduodenal manometry in healthy volunteers showed that the contraction pattern during sleeping is different from waking 40,42. MMC duration during sleeping is shorter with mean duration of 80 minutes compare to 100 minutes during waking.…”

Section: Discussionmentioning

confidence: 99%

Technique of Functional and Motility Test: How to Perform Antroduodenal Manometry

Patcharatrakul¹,

Gonlachanvit²

2013

J Neurogastroenterol Motil

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Antroduodenal manometry is one of the methods to evaluate stomach and duodenal motility. This test is a valuable diagnostic tool for gastrointestinal motility disorders especially small intestinal pseudo-obstruction which is difficult to make definite diagnosis by clinical manifestations or radiologic findings. Manometric findings that have no evidence of mechanical obstruction and suggestive of pseudo-obstruction with neuropathy or myopathy can avoid unnecessary surgery and the treatment can be directly targeted. Moreover, among patients who have clinically suspected small intestinal pseudo-obstruction but with normal manometric findings, the alternative diagnosis including psychiatric disorder or other organic disease should be considered. The application of this test to the patients with functional gastrointestinal symptoms especially to find the association of motor abnormalities to the symptom has less impressive yield. Antroduodenal manometry is now readily available only in some tertiary care centers. The aim of this review is to describe the antroduodenal manometry technique, interpretation and clinical utility.

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“…The fact that the motor effects of amoxicillin-clavulanate were more pronounced during the nocturnal fast than during the diurnal fast could be explained, in part, by the circadian variations of the small bowel motor patterns. It has been shown that intestinal motor activity is usually important during waking but is limited during sleeping (8). Therefore, the demonstration of an increase in motor activity was certainly more difficult during the diurnal than during the nocturnal part of the study.…”

Section: Discussionmentioning

confidence: 99%

Effects of amoxicillin-clavulanate combination on the motility of the small intestine in human beings

Caron

Ducrotté

Lerebours

et al. 1991

Antimicrob Agents Chemother

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The amoxicillin-clavulanate combination (Augmentin) frequently induces gastric complaints and diarrhea by an unknown mechanism. The aim of this study was to assess the effects of two orally therapeutic regimens of amoxicillin-clavulanate on small bowel motility in human beings. Duodeno-jejunal manometric recordings were performed in six healthy subjects treated in a cross-over double-blind study with placebo; amoxicillinclavulanate, 1 g plus 250 mg per os every 12 h for 3 days; or amoxicillin-clavulanate, 1 g plus 250 mg per os every 12 h on day 3 only (1-day regimen). Recordings were all performed on day 3 during a diurnal fasting period, a fed state after a standard dinner, and a nocturnal fasting period. Amoxicillin-clavulanate did not affect the motility of the small intestine during the diurnal fast or the fed state. During the nocturnal fast, amoxicillin-clavulanate significantly increased the motility index of the nonpropagated contractions and tended to increase the duration and the amplitude of the propagated contractions. The same digestive motor effect was already observed on the first day of treatment (1-day regimen). This study demonstrates that the oral administration of a therapeutic regimen of amoxicillin-clavulanate is associated, in most cases, with the occurrence of small intestinal motor disturbances.The amoxicillin-clavulanate combination (Augmentin), one of the most widely used antibiotics, frequently induces gastrointestinal side effects, such as nausea, vomiting, cramping (prevalence, 3 to 6%), or diarrhea (prevalence, 4 to 15%) (3, 5). These prevalences are higher than those reported with other orally administrated beta-lactams (10). These effects are usually minor and transient, but they sometimes lead to interruption of the treatment (3). As for other broad-spectrum antibiotics, disturbances of the normal gastrointestinal microfiora are often incriminated, but there is no proof of this. The aim of this study was to test whether the oral administration of a therapeutic regimen of amoxicillin-clavulanate in healthy volunteers is accompanied by changes in small bowel motility, as reported previously for macrolide antibiotics (11). MATERIALS AND METHODSSubjects. Seven healthy male volunteers (ages, 22 to 28 years) were included in the study. No subject was taking any medication or had a history of gastrointestinal symptoms or surgery. The study was approved by the Ethical Committee of the Medical University of Rouen, and written informed consent was obtained from each subject.Recording system. As reported previously (4, 6), intraluminal pressures were recorded from four side holes cut into an assembly of four polyvinyl tubes (internal diameter, 0.8 mm). The sensors were located at 5, 15, 25, and 35 cm from a rubber stall containing 2 ml of mercury and fixed to the tip of the tube to facilitate positioning. Radiopaque marks were inserted in the catheters near the side holes and at the tip to facilitate the fluoroscopic control of the position to the assembly. The probe was advanced so that ...

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Modulation of the duration of human postprandial motor activity by sleep

Cited by 20 publications

References 0 publications

Telemetry Facilitates Long‐Term Recording of Gastrointestinal Myoelectrical Activity in Pigs

Telemetry Facilitates Long‐Term Recording of Gastrointestinal Myoelectrical Activity in Pigs

Technique of Functional and Motility Test: How to Perform Antroduodenal Manometry

Effects of amoxicillin-clavulanate combination on the motility of the small intestine in human beings

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