Modulation of the immune response by POMC-derived peptides

Heijnen, Cobi J.; Zijlstra, Jitske; Kavelaars, Annemieke; Croiset, Gerda; Ballieux, R. E.

doi:10.1016/0889-1591(87)90031-6

Cited by 61 publications

(6 citation statements)

References 19 publications

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“…2). A comparable bimodal dose-response curve could also be observed for the modulatory effect of P-endorphin on the proliferative response of Tcells after stimulation with the Tcell mitogen Con A [14].…”

Section: Cell Lysis and Immunoprecipitationsupporting

confidence: 52%

“…There is pharmacological evidence, obtained from functional assays, for the presence of opiate binding sites on lymphocytes (reviewed in [15]). However, it has been demonstrated that p-endorphin can also influence immune responses such as antibody synthesis and T cell proliferation via a non-opiate receptor-mediated mechanism [14][15][16][17]. Binding of P-endorphin to opiate receptors can be prevented by acetylation of the N terminus of the peptide [18].…”

Section: Cell Lysis and Immunoprecipitationmentioning

confidence: 99%

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The phosphorylation of the CD3 γ chain of T lymphocytes is modulated by β‐endorphin

Kavelaars

Eggen

Graan³

et al. 1990

Eur J Immunol

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The neuropeptide beta-endorphin can modulate the response of T and B cells to mitogenic or antigenic stimulation. In the present report we describe a novel mechanism by which beta-endorphin can interfere with T cell activation. It is shown here that beta-endorphin can modulate the phorbol ester-induced phosphorylation of the gamma chain of the CD3 complex. The effect of beta-endorphin is dose dependent and appears to be mediated via interaction of beta-endorphin with an opiate receptor on lymphocytes. Evidence is presented that the modulatory effect of beta-endorphin is specific for the phosphorylation of the CD3 gamma chain. beta-Endorphin does not affect the phosphorylation of total cell protein, nor does it have any effect on the phosphorylation of the CD4 determinant on T cells. The possible consequence of a change in CD3 gamma chain phosphorylation is discussed.

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Section: Cell Lysis and Immunoprecipitationsupporting

confidence: 52%

Section: Cell Lysis and Immunoprecipitationmentioning

confidence: 99%

The phosphorylation of the CD3 γ chain of T lymphocytes is modulated by β‐endorphin

Kavelaars

Eggen

Graan³

et al. 1990

Eur J Immunol

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“…Increases in cortisol, for instance, are associated with immunomodulation, especially with decreases in circulating lymphocytes (62). Depending on the metabolic state of the lymphocytes, results (in vitro) show both inhibitory as well as facilitating effects of /3-endorphin on the proliferation of lymphocytes (63,64). Depending on the metabolic state of the lymphocytes, results (in vitro) show both inhibitory as well as facilitating effects of /3-endorphin on the proliferation of lymphocytes (63,64).…”

Section: Recoverymentioning

confidence: 99%

Experimental Social Fear

Gerritsen

Heijnen²,

Wiegant

et al. 1996

Psychosomatic Medicine

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The aims of the two studies were to investigate the relationship between emotions and immune responses in an experimental setting by inducing social fear and to broaden our understanding of bodily reactions by examining both cardiovascular and hormonal responses. Seventy-nine healthy subjects were confronted with a situation in which relatively strong social fear was induced in the laboratory. Social fear was induced by having to prepare and give an oral presentation in front of an audience. Thirty additional healthy subjects formed a control group; they followed exactly the same procedure, but, instead of the "public speaking situation," they were subjected to a nondemanding task of the same duration. The results indicate that public speaking evoked fear as shown by both elevated feelings of tenseness and negative bodily sensations. Moreover, the data clearly show enhanced cardiovascular activity, elevated plasma hormone levels, and changes in immunological parameters (natural killer cell number and T helper/inducer cells). The control group reported significantly less feelings of tenseness and negative bodily sensations and showed a decrease in cortisol, prolactin, and beta-endorphin levels. Although some variation on immune responses was present, no variation on cardiovascular activity occurred in the control group during the experiment. The results show that there is indeed a relationship between emotion and immune responses. In addition, the data collected on body responses point to a direct mediating effect of sympathetic-adrenal medulla activity and an indirect mediating effect of hypothalamo-pituitary-adrenal axis activity.

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“…Concerning T-lymphocyte activation, both stimulatory (Fontana et al, 1987;Gilman et al, 1982;Gilmore and Weiner, 1989;Heijnen et al, 1987;Kusnecov et al, 1987;van den Bergh et al, 1991b) and inhibitory (Manfredi et al, 1993;McCain et al, 1982;Panerai et al, 1995;Puppo et al,1985) effects of h-endorphin on lymphocyte proliferation have been described. The action on Th1/Th2 cytokines is also controversial: both enhancement (Bessler et al, 1990;van den Bergh et al, 1991b) or inhibition (Garcia et al, 1992) of IL-2 production by h-endorphin were described.…”

Section: Introductionmentioning

confidence: 99%