Modulation of the infant immune responses by the first pertussis vaccine administrations

Mascart, Françoise; Hainaut, Marc; Peltier, Alexandra; Verscheure, Virginie; Levy, Jack S.; Locht, Camille

doi:10.1016/j.vaccine.2006.06.046

Cited by 88 publications

(88 citation statements)

References 31 publications

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“…11 It is well recognized that whole-cell and acellular pertussis vaccines trigger different immune responses in infants. 19,20 Both vaccines yield high specific…”

Section: Discussionmentioning

confidence: 99%

Comparative Effectiveness of Acellular Versus Whole-Cell Pertussis Vaccines in Teenagers

et al. 2013

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BACKGROUND: During the 1990s, the United States switched from combined diphtheria, tetanus toxoids, whole-cell pertussis (DTwP) vaccines to combined acellular pertussis (DTaP) vaccines because of safety concerns. After a 2010–2011 pertussis outbreak, we sought to evaluate whether disease risk in 10 to 17 year olds differed between those who previously received DTwP from those who received DTaP. METHODS: A case-control study among individuals born from 1994 to 1999 who received 4 pertussis-containing vaccines during the first 2 years of life at Kaiser Permanente Northern California (KPNC). We separately compared pertussis polymerase chain reaction (PCR)-positive cases with PCR-negative and KPNC-matched controls. We assessed risk of pertussis relative to vaccine type in early childhood (4 DTwPs, mixed DTwP/DTaP, or 4 DTaPs) by using conditional logistic regression stratified for calendar time and adjusted for gender, race, medical clinic, and receipt of reduced antigen content acellular pertussis (Tdap) vaccine. RESULTS: We compared 138 PCR-positive cases with 899 PCR-negative and 54 339 KPNC-matched controls. Teenagers who had received 4 DTwPs were much less likely to be pertussis PCR-positive than those who had received 4 DTaPs (odds ratio 5.63, 95% confidence interval 2.55–12.46) or mixed DTwP/DTaP vaccines (odds ratio 3.77, 95% confidence interval 1.57–9.07). Decreasing number of DTwP doses was significantly associated with increased pertussis risk (P < .0001). CONCLUSIONS: Teenagers who received DTwP vaccines in childhood were more protected during a pertussis outbreak than were those who received DTaP vaccines.

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“…11 It is well recognized that whole-cell and acellular pertussis vaccines trigger different immune responses in infants. 19,20 Both vaccines yield high specific…”

Section: Discussionmentioning

confidence: 99%

Comparative Effectiveness of Acellular Versus Whole-Cell Pertussis Vaccines in Teenagers

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Possible explanations for our findings could include antigenic shifts in circulating Bordetella pertussis strains2 or the different immune responses from acellular and whole-cell priming (121).…”

Section: Commentmentioning

confidence: 95%

“…aP vaccination stimulates serum IgE production to both pertussis toxins and co-administered antigens such as tetanus and diphtheria toxoids (121,165,171). Booster doses of aP further enhance the IgE response (171).…”

Section: Immunobiology Of Pertussis Vaccinesmentioning

confidence: 99%

“…Gradually, Th1 responses become increasingly prominent during infancy, as indicated by an improved ability of T cells to produce interferon gamma (IFNγ), an important immunoregulatory cytokine (176,178). Vaccines given in infancy have the potential to delay or promote the IFN secreting ability of infants (121,178). A temporary maturational delay in Th1 function, more specifically in the production of IFNγ, may occur after aP vaccination (121).…”

Section: Cellular Immunitymentioning

confidence: 99%

“…Vaccines given in infancy have the potential to delay or promote the IFN secreting ability of infants (121,178). A temporary maturational delay in Th1 function, more specifically in the production of IFNγ, may occur after aP vaccination (121). Th2 skewing of infant immune responses following priming with aP vaccines may result from the combined effect of the Th2-biased phenotype at birth, together with the presence of alum (in some aP products) and PT which both have Th2-stimulating properties, and the absence of cell wall-derived Th1-stimulating ligands in aP vaccines (170,179,180).…”

Section: Cellular Immunitymentioning

confidence: 99%

See 2 more Smart Citations

Assessing vaccine effectiveness of publicly funded vaccination programs in Queensland

Sheridan¹

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Number and Order of Whole Cell Pertussis Vaccines in Infancy and Disease Protection

Sheridan¹,

Ware²,

Grimwood³

et al. 2012

JAMA

236

162

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Modulation of the infant immune responses by the first pertussis vaccine administrations

Cited by 88 publications

References 31 publications

Comparative Effectiveness of Acellular Versus Whole-Cell Pertussis Vaccines in Teenagers

Comparative Effectiveness of Acellular Versus Whole-Cell Pertussis Vaccines in Teenagers

Assessing vaccine effectiveness of publicly funded vaccination programs in Queensland

Number and Order of Whole Cell Pertussis Vaccines in Infancy and Disease Protection

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