Modulation of the interaction of Coumarin 7 with DNA by β-cyclodextrin

Chandrasekaran, S.; Yousuf, Sameena; Enoch, Israel V.M.V.

doi:10.1007/s10847-014-0451-1

Cited by 27 publications

(18 citation statements)

References 21 publications

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“…26 Hence, the surface-loaded chromenones are able to bind to DNA, although doing so with lower binding constant values than the free CHR-DNA binding. K SV , in this case, is calculated as 1.27 Â 10 5 M À1 .…”

Section: View Article Onlinementioning

confidence: 99%

Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: openness to bind to β-cyclodextrin and DNA

et al. 2015

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This paper presents the loading of chromenones, viz., flavanone, hesperetin, naringenin, coumarin 6 and coumarin 7 onto aminoethylamino-modified dextran-coated superparamagnetic iron oxide core-shell nanoparticles. The chemically modified iron oxide core-shell nanoparticles retain their superparamagnetic behaviour even upon chromenone loading. The accessibility of loaded chromenones to DNA for binding is analysed using UV-visible absorption and fluorescence spectroscopy. b-Cyclodextrin is used as an aid to detect whether the chromenones are buried inside the aminoethylamino-modified dextran-coated superparamagnetic iron oxide core-shell nanoparticle shell or available on the surface to readily bind to the macromolecular target. The stoichiometry of the loaded chromenones with the b-cyclodextrin inclusion complex is 1 : 1 in all cases, except with naringenin which binds to two b-cyclodextrin molecules.Coumarin 7 shows a fluorescence quenching upon binding to calf thymus DNA. This study could improve the understanding of the mode of binding of small molecules loaded on magnetic nanoparticles to DNA.

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Section: View Article Onlinementioning

confidence: 99%

Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: openness to bind to β-cyclodextrin and DNA

et al. 2015

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“…The synthesis of C-Hexylpyrogallol [4]arene is reported elsewhere [20]. In a typical procedure, an alcoholic solution of pyrogallol (10 mmol) was acidified with Conc.…”

Section: Synthesis Of C-hexylpyrogallol[4]arene (C-hpa)mentioning

confidence: 99%

“…Hence this neutral-monocation equilibrium of 7-AF is influenced by the C-HPA binding. The ground state pK a value is calculated as below [26],…”

Section: Host-guest Interaction Of Fl With C-hpamentioning

confidence: 99%

“…In this line, the mode of binding of small molecules to C-HPA needs to be studied in detail. A few reports on the inclusion complex formation of small molecules with C-HPA are available in the literature [20]. In this paper, we report the interaction of flavanone (FL) and 7-aminoflavone (7-AF) with C-HPA and discuss the structure of the host-guest complexes using spectroscopic methods.…”

Section: Introductionmentioning

confidence: 99%

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Host–guest interaction of flavanone and 7-aminoflavone with C-Hexylpyrogallol[4]arene

Chandrasekaran

Enoch

2014

Journal of Molecular Structure

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“…Fluorescence enhancement is the most observed property on such host-guest complex formation, 8 whereas quenching of uores-cence also is scarcely reported. 9 Knowing the exact structure of the host-guest complex is of paramount importance in understanding the alteration of the physicochemical properties and the spectroscopic behavior of the guest molecules. Benzothiazoles are pharmacologically active molecules and their derivatives have been prepared using a wide range of methodologies.…”

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Enhanced Zn²⁺ion-sensing behavior of a benzothiazole derivative on encapsulation by β-cyclodextrin

et al. 2016

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We report, in this paper, a benzothiazole derivative which shows selective binding of zinc ions among a pool of metal ions and the enhanced selectivity of the same metal ion by the derivative in its b-cyclodextrin bound form. The Zn 2+ ion binding is studied using UV-visible absorption and fluorescence spectroscopy.The stoichiometry and binding mode of the benzothiazole derivative-b-cyclodextrin complex are determined using 1D and 2D NMR spectroscopic analysis. The cyclodextrin molecule slides over the benzothiazole derivative and resides above the aminomethyl group linking the benzothiazole and dihydroxyphenyl moieties. The site of binding of the Zn 2+ ion with the compound remains the same both in the compound's free and cyclodextrin-complexed forms. Molecular modeling studies were also carried out in order to obtain more details about the cyclodextrin-compound and Zn 2+ -compound interactions, and their results are in close agreement with obtained experimental data.

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Modulation of the interaction of Coumarin 7 with DNA by β-cyclodextrin

Cited by 27 publications

References 21 publications

Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: openness to bind to β-cyclodextrin and DNA

Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: openness to bind to β-cyclodextrin and DNA

Host–guest interaction of flavanone and 7-aminoflavone with C-Hexylpyrogallol[4]arene

Enhanced Zn²⁺ion-sensing behavior of a benzothiazole derivative on encapsulation by β-cyclodextrin

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Modulation of the interaction of Coumarin 7 with DNA by β-cyclodextrin

Cited by 27 publications

References 21 publications

Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: openness to bind to β-cyclodextrin and DNA

Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: openness to bind to β-cyclodextrin and DNA

Host–guest interaction of flavanone and 7-aminoflavone with C-Hexylpyrogallol[4]arene

Enhanced Zn2+ion-sensing behavior of a benzothiazole derivative on encapsulation by β-cyclodextrin

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Enhanced Zn²⁺ion-sensing behavior of a benzothiazole derivative on encapsulation by β-cyclodextrin